Functional components, antidiabetic, anti-Alzheimer’s disease, and antioxidant activities of <i>Salvia syriaca</i> L.

Bahadori, Mir Babak; Dinparast, Leila; Zengin, Gökhan; Sarıkürkçü, Cengiz; Bahadori, S H Ranjbar; Asghari, Behvar; Movahhedin, Nasrin

doi:10.1080/10942912.2016.1218893

Cited by 71 publications

(46 citation statements)

References 42 publications

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“…Though, the choice of method and the solvent used for extraction plays a vital role in the determination of the antioxidant potential of the prepared extracts. In similar studies, it was found that the antioxidant potential of extracts depends upon the total phenolic and flavonoid contents [22,32], that is in accordance with our study. Thus, in this study, the higher amount of total phenolic and flavonoid content may be responsible for the potent antioxidant potential.…”

Section: Antioxidant Potentialsupporting

confidence: 92%

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

et al. 2020

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This research endeavors to inspect the chemical and biological profiling of methanol and dichloromethane (DCM) extracts prepared from Abutilon figarianum Webb. Total bioactive constituents and secondary metabolites were assessed via ultra-high performance liquid chromatography (UHPLC-MS). Biological effects were evaluated via antioxidant and enzymes inhibitory assays. The methanol extract was able to give the highest phenolic (51.92 mg GAE/g extract) and flavonoid (72.59 mg QE/g extract) contents and was found to contain 11 bioactive metabolites, including flavonoid, alkaloid, phenolic and fatty acid derivatives, as accessed by UHPLC-MS analysis. Similarly, the phytochemical profiling of the DCM extract tentatively identified the 12 different secondary metabolites, most of these were fatty acid derivatives. The methanol extract was most active in the radical scavenging, reducing power and total antioxidant power assays, while dichloromethane extract showed the highest metal chelating activity. For enzyme inhibition, the DCM extract showed the highest activity against cholinesterases, glucosidase and amylase, whereas methanol extract was most active against tyrosinase. Docking studies have supported the observed biological activity, where isobergapten showed higher activity against tyrosinase (−7.63 kcal/mol) with inhibition constant (2.55 µM), as opposed to other enzymes. The observed antioxidant and inhibitory potentials of A. figarianum against the studied enzymes tend to endorse this plant as a prospective source of bioactive phytochemicals.

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Section: Antioxidant Potentialsupporting

confidence: 92%

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

et al. 2020

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“…Both essential oils exhibited the same anti‐enzymatic activity, which was approximately four times lower than that of acarbose ( P < 0.05). The antidiabetic activities of essential oils have been documented from plants including Origanum vulgare , Artemisia herba and Ocimum basilicum , Coleus aromaticus , Salvia syriaca , Afromomum melegueta and Afromomum danieli , and Syzygium aromaticum and Cuminum cyminum. The antidiabetic activities of carvacrol, thymol, and linalool have been confirmed by in vitro and in vivo studies …”

Section: Resultsmentioning

confidence: 99%

Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

Kırkan

Sarıkürkçü

Amarowicz

2019

Flavour & Fragrance J

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This research sought to characterize the essential oils of Satureja thymbra and Thymbra spicata var. spicata in terms of composition as well as their antioxidant and enzyme‐inhibitory activities. The major components of essential oil derived from S. thymbra were found to be γ‐terpinene (34.67%), carvacrol (32.45%), p‐cymene (11.46%), and β‐caryophyllene (6.85%). In the essential oil derived from T. spicata var. spicata the most abundant compounds were carvacrol (63.23%), γ‐terpinene (18.94%), and p‐cymene (8.31%). The essential oils exhibited antioxidant properties, based on ABTS, DPPH, FRAP, and ORAC assays, as well as antiradical activity against superoxide, nitric oxide, and hydroxyl radicals, and ferrous ion chelating activity. The essential oils were found to have inhibitory effects against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, and α‐glucosidase. Considering the results obtained, the essential oils from both plants can be used as ingredients in pharmaceuticals or as natural additives in the food industry for promoting health.

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“…Taking into account that the determined dominant phenolics express great bioactivity, that it is confirmed that they prevent several diseases such as cancer, cardiovascular ailments, neurodegenerative diseases, obesity, and infectious disease, and that the juniper is already introduced into diet, the juniper-fortified food products could be considered as potent nutraceuticals in general health promotion. [21,22,23] Furthermore, a considerable content of catechin, rutin, and quercetin indicates J. excelsa as a natural preservative for stopping food spoilage by bacteria and fungi or LP during preparation, storage, and distribution. [1,24,25] .…”

Section: Resultsmentioning

confidence: 99%

Bioactivity and chemical profiling of the Juniperus excelsa, which support its usage as a food preservative and nutraceutical

Lesjak

Beara

Orčić

et al. 2017

International Journal of Food Properties

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Leaves and cones of the genus Juniperus, regularly used as a spice, could be a candidate for new food preservative with significant nutraceutical qualities. The main goal of this study was to evaluate the bioactivity and chemical profiling of the Juniperus excelsa leaves and cones in order to support its usage as a health-promoting food additive. The content of 44 phenolics was determined using Liquid chromatography tandem-mass spectrometry (LS-MS/MS), with catechin and quercitrin being the most dominant, especially in leaves (234 and 142 mg/g of leaves dry weight, respectively). Gas chromatography-mass spectrometry (GC-MS) analysis showed a simple terpene composition both in leaves and in cones, with α-pinene (31 and 77%), cedrol (37 and 8%), and limonene (15 and 6%) as the most abundant compounds, respectively. J. excelsa showed a noteworthy antioxidant effect comparable with butylated hydroxyanisole (BHA), especially leaves extract towards HO • and lipid peroxidation (LP) inhibition, which is particularly important in food-quality maintenance. Essential oil of leaves showed significant anti-inflammatory activity by means of inhibition of eicosanoids production and considerable antimicrobial activity against the clinically relevant and/or foodborne illness-causing bacteria. Due to its considerable bioactivity and high content of phenolics with proven health benefits, usage of J. excelsa as a food additive with valuable nutraceutical properties should be supported.

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Functional components, antidiabetic, anti-Alzheimer’s disease, and antioxidant activities of Salvia syriaca L.

Abstract: View related articles View Crossmark data Citing articles: 24 View citing articles Functional components, antidiabetic, anti-Alzheimer's disease, and antioxidant activities of Salvia syriaca L.

Cited by 71 publications

References 42 publications

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

Bioactivity and chemical profiling of the Juniperus excelsa, which support its usage as a food preservative and nutraceutical

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