Functional Conductive Hydrogels for Bioelectronics

Fu, Fanfan; Wang, Jilei; Zeng, Hongbo; Yu, Jing

doi:10.1021/acsmaterialslett.0c00309

Cited by 253 publications

(190 citation statements)

References 164 publications

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“…Conductive hydrogels are gaining significant interest from the bioelectronics community as they can act as soft interfaces between biological and electronic systems, offering an alternative to traditional inorganic materials [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Conductive Gelatine-Methacrylate Inks for Two-Photon Polymerisation

et al. 2021

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Conductive hydrogel-based materials are attracting considerable interest for bioelectronic applications due to their ability to act as more compatible soft interfaces between biological and electrical systems. Despite significant advances that are being achieved in the manufacture of hydrogels, precise control over the topographies and architectures remains challenging. In this work, we present for the first time a strategy to manufacture structures with resolutions in the micro-/nanoscale based on hydrogels with enhanced electrical properties. Gelatine methacrylate (GelMa)-based inks were formulated for two-photon polymerisation (2PP). The electrical properties of this material were improved, compared to pristine GelMa, by dispersion of multi-walled carbon nanotubes (MWCNTs) acting as conductive nanofillers, which was confirmed by electrochemical impedance spectroscopy and cyclic voltammetry. This material was also confirmed to support human induced pluripotent stem cell-derived cardiomyocyte (hPSC-CMs) viability and growth. Ultra-thin film structures of 10 µm thickness and scaffolds were manufactured by 2PP, demonstrating the potential of this method in areas spanning tissue engineering and bioelectronics. Though further developments in the instrumentation are required to manufacture more complex structures, this work presents an innovative approach to the manufacture of conductive hydrogels in extremely low resolution.

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Section: Introductionmentioning

confidence: 99%

Development of Conductive Gelatine-Methacrylate Inks for Two-Photon Polymerisation

et al. 2021

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“…They collect bioelectronic signals and enable personalized self-monitoring of tissues. 256,257 Bioelectronics are widely used in various applications, including electronic skin, the detection of brain activity, so robotics and wearable and exible implantable devices. 258 Before the invention of CPH, inorganic materials were widely used for the fabrication of bioelectronic devices.…”

Section: Conducting Polymer Hydrogels (Cph) For Bioelectronicsmentioning

confidence: 99%

Conducting polymers: a comprehensive review on recent advances in synthesis, properties and applications

2021

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“…Recently, hydrogels [ 113 , 114 ] have gained promising attention in advanced wearable sensors due to their mechanical properties. However, manufacturing a skin-like stretchable and conductive hydrogel with desired synergistic characteristics of stretchability, higher self-healing capacity and an excellent sensing performance still remain a challenge [ 115 ].…”

Section: Wearable Devices and Their Featuresmentioning

confidence: 99%

Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring

et al. 2021

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With the increasing prevalence of growing population, aging and chronic diseases continuously rising healthcare costs, the healthcare system is undergoing a vital transformation from the traditional hospital-centered system to an individual-centered system. Since the 20th century, wearable sensors are becoming widespread in healthcare and biomedical monitoring systems, empowering continuous measurement of critical biomarkers for monitoring of the diseased condition and health, medical diagnostics and evaluation in biological fluids like saliva, blood, and sweat. Over the past few decades, the developments have been focused on electrochemical and optical biosensors, along with advances with the non-invasive monitoring of biomarkers, bacteria and hormones, etc. Wearable devices have evolved gradually with a mix of multiplexed biosensing, microfluidic sampling and transport systems integrated with flexible materials and body attachments for improved wearability and simplicity. These wearables hold promise and are capable of a higher understanding of the correlations between analyte concentrations within the blood or non-invasive biofluids and feedback to the patient, which is significantly important in timely diagnosis, treatment, and control of medical conditions. However, cohort validation studies and performance evaluation of wearable biosensors are needed to underpin their clinical acceptance. In the present review, we discuss the importance, features, types of wearables, challenges and applications of wearable devices for biological fluids for the prevention of diseased conditions and real-time monitoring of human health. Herein, we summarize the various wearable devices that are developed for healthcare monitoring and their future potential has been discussed in detail.

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Functional Conductive Hydrogels for Bioelectronics

Cited by 253 publications

References 164 publications

Development of Conductive Gelatine-Methacrylate Inks for Two-Photon Polymerisation

Development of Conductive Gelatine-Methacrylate Inks for Two-Photon Polymerisation

Conducting polymers: a comprehensive review on recent advances in synthesis, properties and applications

Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring

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