Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder

Chepenik, Lara G.; Raffo, Mariella; Hampson, Michelle; Lacadie, Cheryl; Wang, Fei; Jones, Monique; Pittman, Brian; Skudlarski, Pawel; Blumberg, Hilary P.

doi:10.1016/j.pscychresns.2010.04.002

Cited by 166 publications

(123 citation statements)

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“…Moreover, when considering extant bipolar or PTSD samples with available resting-state data, baseline connectivity differences have been reported in DMN regions distinct from those found in our BPD sample. 60,61 More recently, a study investigating multiple RSNs in medication-free patients with major depression 20 reported a pattern of dysfunction different from the pattern of dysconnectivity observed in our BPD sample. However, definite conclusions about the specificity of the present findings to BPD can only be drawn by rs-fMRI studies of 2 or more clinical groups.…”

Section: Discussionmentioning

confidence: 61%

Aberrant connectivity of resting-state networks in borderline personality disorder

Wolf

Sambataro

Vasić

et al. 2011

jpn

109

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Background: Several functional neuroimaging studies have reported regionally abnormal activation of the frontal cortex in individuals with borderline personality disorder (BPD) during cognitive and affective task performance. However, little is known about neural function in individuals with BPD during the resting state. Using functional magnetic resonance imaging (fMRI), this study investigated the functional connectivity of prefrontal and limbic networks in patients with BPD. Methods: Between January 2009 and March 2010, we investigated patients with BPD according to DSM-IV criteria and healthy controls by means of resting-state fMRI. The data were analyzed using a spatial group independent component analysis, and random effects t tests were used to compare spatial components between groups (p < 0.005, uncorrected). Results: There were 17 women with BPD and 17 female healthy controls enrolled in this study. Within a network comprising cortical midline regions ("default mode network"), patients with BPD showed an increase in functional connectivity in the left frontopolar cortex (FPC) and the left insula, whereas decreased connectivity was found in the left cuneus. Within a network comprising predominantly right lateral prefrontal and bilateral parietal regions, patients with BPD showed decreased connectivity of the left inferior parietal lobule and the right middle temporal cortex compared with healthy controls. Two networks comprising lateral prefrontal and cingulate regions did not exhibit significant between-group differences. We found correlations between functional connectivity of the FPC and measures of impulsivity as well as between connectivity of the insula/cuneus and dissociation tension. Limitations: Co-occurrent axis I disorders and medication use in this sample of patients with BPD have to be considered as potential limitations. Conclusion: These data suggest that abnormal functional connectivity of temporally coherent resting-state networks may underlie certain symptom clusters in patients with BPD

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Section: Discussionmentioning

confidence: 61%

Aberrant connectivity of resting-state networks in borderline personality disorder

Wolf

Sambataro

Vasić

et al. 2011

jpn

109

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“…[32][33][34][35] Resting-state connectivity offers a powerful way to assess intrinsic connections between brain networks, 3,4,36 which in turn have been linked to important functions such as processing speed 37 and cognitive flexibility 38 in health and in disease. Resting-state amygdala connectivity may have particular relevance for the study of mood and anxiety disorders, as it has been reported to be altered in individuals with generalized anxiety disorder (GAD), 39 social phobia, 40 major depressive disorder (MDD) 41,42 and bipolar disorder; 43 however, amygdala connectivity at rest in individuals with PTSD has not been studied. Given hypotheses that the mPFC exerts regulatory control over the amygdala, we hypothesized anticorrelations between the mPFC and amygdala, and positive connectivity between the amygdala and insula.…”

Section: Introductionmentioning

confidence: 99%

Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder

Sripada

King

Garfinkel

et al. 2012

jpn

326

294

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IntroductionPosttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder characterized by symptoms of re-experiencing, hyperarousal, emotional numbing and avoidance; 1 however, exact brain mechanisms involved in the generation of PTSD symptoms or in PTSD pathophysiology have yet to be elucidated. Converging neuroimaging research points to a potentially critical role for disrupted emotion neurocircuitry in individuals with PTSD, and whereas many studies have delineated patterns of activations during face viewing or symptom provocation (for a review, see Shin and Liberzon 2 ), relatively few have examined patterns of connectivity in the brains of patients with PTSD at rest, a potentially powerful method for illuminating brain network structure. 3,4 Most PTSD neuroimaging studies to date have described abnormalities in emotion-generation regions, such as the amygdala or insula, and emotion-regulation regions, including the anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC). This is consistent with the known role of the amygdala as a key region in threat detection, 5 fear conditioning 6 and emotional salience, 7 and of the mPFC as a modulatory region interconnected with limbic structures 8 and involved in emotion regulation.9 Taken together, functional magnetic resonance imaging (fMRI) studies of individuals with PTSD suggest patterns of hyperactivation of the amygdala and insula to emotion-related stimuli and corresponding hypoactivation of ventromedial prefrontal and rostral anterior cingulate cortices.2 This pattern of amygdala hyperactivity and mPFC hypoactivity was recently confirmed by a meta-analysis of 15 PTSD neuroimaging studies 10 and is generally understood to reflect a lack of regulatory control over emotion in individuals with PTSD.Studies of functional connectivity, however, can provide additional and potentially more direct information about regu latory relationships between the mPFC and amygdala. The amygdala has tight structural connections and reciprocal feedback loops with the mPFC and orbitofrontal cortex 11 as well as with the dorsolateral PFC 12 and ACC. 13 As amygdala Background: Converging neuroimaging research suggests altered emotion neurocircuitry in individuals with posttraumatic stress disorder (PTSD). Emotion activation studies in these individuals have shown hyperactivation in emotion-related regions, including the amygdala and insula, and hypoactivation in emotion-regulation regions, including the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). However, few studies have examined patterns of connectivity at rest in individuals with PTSD, a potentially powerful method for illuminating brain network structure. Methods: Using the amygdala as a seed region, we measured resting-state brain connectivity using 3 T functional magnetic resonance imaging in returning male veterans with PTSD and combat controls without PTSD. Results: Fifteen veterans with PTSD and 14 combat controls enrolled in our study. Compared with controls, veterans with ...

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“…Coherent spontaneous blood oxygen level-dependent (BOLD) activity during rest among specific subsets of brain regions is thought to reflect the natural organization of brain networks (Biswal et al, 1995;see Buckner et al, 2008;Fox and Raichle, 2007, for a review). Abnormal resting-state functional connectivity patterns have been observed in both schizophrenia (Bluhm et al, 2007;Lynall et al, 2010;Whitfield-Gabrieli et al, 2009;Zhou et al, 2007) and bipolar disorder (Anand et al, 2009;Chepenik et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

Chai

Whitfield-Gabrieli

Shinn

et al. 2011

Neuropsychopharmacol

293

205

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Bipolar disorder and schizophrenia overlap in symptoms and may share some underlying neural substrates. The medial prefrontal cortex (MPFC) may have a crucial role in the psychophysiology of both these disorders. In this study, we examined the functional connectivity between MPFC and other brain regions in bipolar disorder and schizophrenia using resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data were collected from 14 patients with bipolar disorder, 16 patients with schizophrenia, and 15 healthy control subjects. Functional connectivity maps from the MPFC were computed for each subject and compared across the three groups. The three groups showed distinctive patterns of functional connectivity between MPFC and anterior insula, and between MPFC and ventral lateral prefrontal cortex (VLPFC). The bipolar disorder group exhibited positive correlations between MPFC and insula, and between MPFC and VLPFC, whereas the control group exhibited anticorrelations between these regions. The schizophrenia group did not exhibit any resting-state correlation or anticorrelation between the MPFC and the VLPFC or insula. In contrast, neither patient group exhibited the significant anticorrelation between dorsal lateral prefrontal cortex (DLPFC) and MPFC that was exhibited by the control group. The decoupling of DLPFC with MPFC in bipolar disorder and schizophrenia is consistent with the impaired executive functioning seen in these disorders. Functional connectivity between MPFC and insula/VLPFC distinguished bipolar disorder from schizophrenia, and may reflect differences in the affective disturbances typical of each illness.

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Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder

Cited by 166 publications

References 50 publications

Aberrant connectivity of resting-state networks in borderline personality disorder

Aberrant connectivity of resting-state networks in borderline personality disorder

Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder

Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

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