Functional connectivity in default mode network correlates with severity of hypoxemia in obstructive sleep apnea

Chang, Ya‐Ting; Chen, Yung‐Che; Chen, Yung‐Lung; Hsu, Shih‐Wei; Yang, Feng‐Yueh; Lee, Chen-Chang; Hsu, Po‐Yuan

doi:10.1002/brb3.1889

Cited by 13 publications

(13 citation statements)

References 37 publications

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“…A task-state MRI study demonstrated that the DMN pattern observed in OSA patients showed more deactivated areas and reduced brain activation than that observed in HC (Ayalon et al, 2009;Prilipko et al, 2011). Another study showed that impaired cognitive function and attention in patients with OSA was associated with DMN dysfunction, and it is believed that the main factor is hypoxemia (Chang et al, 2020a). Moreover, DMN impairment has been shown to be an important factor (Cheng et al, 2020;Wang et al, 2020;Qin et al, 2021) and plays a pivotal role in cognitive function (Smallwood et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea

et al. 2022

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PurposePrevious studies found abnormal low-frequency spontaneous brain activity related to cognitive impairment in patients with obstructive sleep apnea (OSA). However, it is unclear if low-frequency spontaneous brain activity is related to specific frequency bands in OSA patients. In this study, we used the amplitude of low-frequency fluctuation (ALFF) method in patients with OSA to explore characteristics of spontaneous brain activity in the classical (0.01–0.1 Hz) and five sub-frequency bands (slow-2 to slow-6) and analyzed the relationship between spontaneous brain activity and clinical evaluation was analyzed.Patients and methodsResting-state magnetic resonance imaging data and clinical assessments were collected from 52 newly-diagnosed OSA patients and 62 healthy controls (HCs). We calculated the individual group ALFF values in the classical and five different sub-frequency bands. A two-sample t-test compared ALFF differences, and one-way analysis of variance explored interactions in frequency bands between the two groups.ResultsALFF values in the OSA group were lower than those in the HC group in the bilateral precuneus/posterior cingulate cortex, bilateral angular gyrus, left inferior parietal lobule, brainstem, and right fusiform gyrus. In contrast, ALFF values in the OSA group were higher than those in the HC group in the bilateral cerebellum posterior lobe, bilateral superior frontal gyrus, bilateral middle frontal gyrus, left inferior frontal gyrus, left inferior temporal gyrus, and left fusiform gyrus. Some ALFF values in altered brain regions were associated with body mass index, apnea-hypopnea index, neck circumference, snoring history, minimum SaO2, average SaO2, arousal index, oxygen reduction index, deep sleep period naming, abstraction, and delayed recall in specific frequency bands.ConclusionOur results indicated the existence of frequency-specific differences in spontaneous brain activity in OSA patients, which were related to cognitive and other clinical symptoms. This study identified frequency-band characteristics related to brain damage, expanded the cognitive neuroimaging mechanism, and provided additional OSA neuroimaging markers.

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Section: Discussionmentioning

confidence: 99%

Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea

et al. 2022

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“…In OSA patients, reduced FC in the pre-DMN and compensatory higher FC in the post-DMN have been reported [51]. A previous study has found that OSA patients exhibit abnormalities in FC between several DMN subregions and abnormalities in spontaneous activity and that these FC changes are related to the severity of OSA and degree of hypoxia [70][71][72][73]. A longitudinal study found that CPAP could effectively improve cerebral function by increasing DMN connectivity [74].…”

Section: Discussionmentioning

confidence: 99%

Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment

Long

Shu

et al. 2023

Neural Plasticity

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This study was aimed at investigating the functional connectivity (FC) changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and at exploring the relationship between resting-state FC changes and cognitive impairment in OSA patients. Data from 15 patients with OSA before and after 6 months of CPAP treatment were included in this study. The FC between the insular subregions and whole brain was compared between baseline and after 6 months of CPAP treatment in OSA. After 6 months of treatment, OSA patients had increased FC from the right ventral anterior insula to the bilateral superior frontal gyrus and bilateral middle frontal gyrus and increased FC from the left posterior insula to the left middle temporal gyrus and left inferior temporal gyrus. Hyperconnectivity was found from the right posterior insula to the right middle temporal gyrus, bilateral precuneus, and bilateral posterior cingulate cortex, which mainly involved the default mode network. There are changes in functional connectivity patterns between the insular subregions and whole brain in OSA patients after 6 months of CPAP treatment. These changes provide a better understanding of the neuroimaging mechanisms underlying the improvement in cognitive function and emotional impairment in OSA patients and can be used as potential biomarkers for clinical CPAP treatment.

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“…et al 10.3389/fnagi.2022.1022628 Frontiers in Aging Neuroscience 06 frontiersin.org is a group of brain regions, including the anterior and medial frontal cortex, bilateral temporal lobes, precuneus, and lateral parietal cortex, that are associated with social behavior, emotional control, memory, learning, and task execution (Raichle, 2015). Ya-ting Chang et al showed that reduced functional connectivity in the DMN was associated with nocturnal hypoxemia rather than sleep rhythms (Chang et al, 2020). Our previous studies have shown that decreased FC between the DMN and the central executive network and decreased functional connectivity between brain networks are associated with delayed memory (Li et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Inherent regional brain activity changes in male obstructive sleep apnea with mild cognitive impairment: A resting-state magnetic resonance study

Shu

Liu²,

Yu³

et al. 2022

Front. Aging Neurosci.

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Obstructive sleep apnea (OSA) is the most common sleep disorder worldwide. Previous studies have shown that OSA patients are often accompanied by cognitive function loss, and the underlying neurophysiological mechanism is still unclear. This study aimed to determine whether there are differences in regional homogeneity (Reho) and functional connectivity (FC) across the brain between OSA patients with MCI (OSA-MCI) and those without MCI (OSA-nMCI) and whether such differences can be used to distinguish the two groups. Resting state magnetic resonance data were collected from 48 OSA-MCI patients and 47 OSA-nMCI patients. The brain regions with significant differences in Reho and FC between the two groups were identified, and the Reho and FC features were combined with machine learning methods for classification. Compared with OSA-nMCI patients, OSA-MCI patients showed significantly lower Reho in bilateral lingual gyrus and left superior temporal gyrus. OSA-MCI patients also showed significantly lower FC between the bilateral lingual gyrus and bilateral cuneus, left superior temporal gyrus and left middle temporal gyrus, middle frontal gyrus, and bilateral posterior cingulate/calcarine/cerebellar anterior lobe. Based on Reho and FC features, logistic regression classification accuracy was 0.87; sensitivity, 0.70; specificity, 0.89; and area under the curve, 0.85. Correlation analysis showed that MoCA scale score in OSA patients was significant positive correlation sleep efficiency and negatively correlation with neck circumference. In conclusion, our results showed that the OSA-MCI group showed decreased Reho and FC in specific brain regions compared with the OSA-nMCI group, which may help to understand the underlying neuroimaging mechanism of OSA leading to cognitive dysfunction and may serve as a potential biomarker to distinguish whether OSA is accompanied by cognitive impairment.

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Functional connectivity in default mode network correlates with severity of hypoxemia in obstructive sleep apnea

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 13 publications

References 37 publications

Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea

Frequency-specific alterations in intrinsic low-frequency oscillations in newly diagnosed male patients with obstructive sleep apnea

Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment

Inherent regional brain activity changes in male obstructive sleep apnea with mild cognitive impairment: A resting-state magnetic resonance study

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