Functional Connectivity in Parkinson's Disease Patients with Mild Cognitive Impairment

Wang, Qingguang; He, Wei; Liu, Dinghua; Han, Bojun; Jiang, Qitao; Niu, Jingyang; Ding, Yong

doi:10.21203/rs.3.rs-20315/v1

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Considering the elevated incidence of dementia in PD patients, a multitude of researchers have been dedicated to identify MRI biomarkers to be indicative of cognitive deterioration in PD in order to facilitate an early identification and prevention. For example, researchers have proposed using cortical thickness on T1WI [31], and white matter structural connectivity on DTI [32] as predictors for PD cognitive progression. Hence, glymphatic dysfunction, assessed by DTI-ALPS, could be used as an additional MRI indicator for predicting cognitive deterioration, and also as a potential supplement for the intervention of cognitive function in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease

Pang,

Wang,

et al. 2024

J Neurol

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Background Although brain glymphatic dysfunction is a contributing factor to the cognitive deficits in Parkinson’s disease (PD), its role in the longitudinal progression of cognitive dysfunction remains unknown. Objective To investigate the glymphatic function in PD with mild cognitive impairment (MCI) that progresses to dementia (PDD) and to determine its predictive value in identifying individuals at high risk for developing dementia. Methods We included 64 patients with PD meeting criteria for MCI and categorized them as either progressed to PDD (converters) (n = 29) or did not progress to PDD (nonconverters) (n = 35), depending on whether they developed dementia during follow-up. Meanwhile, 35 age- and gender-matched healthy controls (HC) were included. Bilateral diffusion-tensor imaging analysis along the perivascular space (DTI-ALPS) indices and enlarged perivascular spaces (EPVS) volume fraction in bilateral centrum semiovale, basal ganglia (BG), and midbrain were compared among the three groups. Correlations among the DTI-ALPS index and EPVS, as well as cognitive performance were analyzed. Additionally, we investigated the mediation effect of EPVS on DTI-ALPS and cognitive function. Results PDD converters had lower cognitive composites scores in the executive domains than did nonconverters (P < 0.001). Besides, PDD converters had a significantly lower DTI-ALPS index in the left hemisphere (P < 0.001) and a larger volume fraction of BG-PVS (P = 0.03) compared to HC and PDD nonconverters. Lower DTI-ALPS index and increased BG-PVS volume fraction were associated with worse performance in the global cognitive performance and executive function. However, there was no significant mediating effect. Receiver operating characteristic analysis revealed that the DTI-ALPS could effectively identify PDD converters with an area under the curve (AUC) of 0.850. Conclusion The reduction of glymphatic activity, measured by the DTI-ALPS, could potentially be used as a non-invasive indicator in forecasting high risk of dementia conversion before the onset of dementia in PD patients.

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Section: Discussionmentioning

confidence: 99%

Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease

Pang,

Wang,

et al. 2024

J Neurol

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Aging of global motion perception is accompanied by the changes of resting-state functional activity in the middle temporal gyrus

Hua¹,

Liang²,

Zhu³

et al. 2021

Acta Psychol Sin

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Results showed that 1) the ReHo values of right V3 and bilateral MT/V5 for older adults were significantly lower than that of younger adults, as well as the ALFF of bilateral MT/V5, and these functional metrics were significantly negatively correlated with individuals' MCT; 2) The FCs between V2 and left primary motor cortex, V3 and left secondary visual cortex, MT/V5 and left premotor cortex, as well as the FCs between V1, V2, V3 and MT/V5 regions for the older adults were significantly stronger than that of younger adults, and these FCs were correlated with individuals' MCT; 3) Older adults' K, E nodal and b of most nodes in temporal lobe were significantly lower than younger adults, and the E nodal of the right temporal cortex were significantly negatively correlated with individuals' MCT; 4) Older adults' global network properties including small-world parameters (C p , γ, L p , λ, and σ) and network efficiency (E glob and E loc) were all significantly lower than younger adults', with C P and E loc significantly negatively correlated with their MCT. These findings suggested that the decline of GMS for the elderly was associated not only with functional changes in the dorsal visual pathway, especially in the MT/V5, but may also with functional changes in broader areas of the whole brain, which supported the theory of "dedifferentiation".

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Functional Connectivity in Parkinson's Disease Patients with Mild Cognitive Impairment

Cited by 2 publications

References 24 publications

Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease

Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease

Aging of global motion perception is accompanied by the changes of resting-state functional activity in the middle temporal gyrus

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