Functional connectivity of cortical resting-state networks is differentially affected by rest conditions

Fernandez, Zachary; Scheel, Norman; Baker, Joshua H.; Zhu, David C.

doi:10.1016/j.brainres.2022.148081

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…In a dim-light environment, a 12-minute rs-fMRI scan will be acquired while the subjects are asked to relax and have their eyes closed [ 26 ]. An eye-closed condition will likely be easier to maintain for our subjects [ 27 , 28 ]. Acquisition parameters: Isotropic voxel size of 2.5 × 2.5 × 2.5 mm 3 , 60 contiguous axial slices, FOV = 22 cm × 22 cm, TE = 30 ms, TR = 1100 ms, FA = 63°, 4 dummy time points discarded, 650 time points, and simultaneous multislice acceleration factor = 4.…”

Section: Methodsmentioning

confidence: 99%

Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

Cunningham,

Adler,

Barber Garcia

et al. 2024

PLoS ONE

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Background Functional abdominal pain disorders (FAPD) are the most common chronic pain conditions of childhood and are made worse by co-occurring anxiety. Our research team found that the Aim to Decrease Pain and Anxiety Treatment (ADAPT), a six-session coping skills program using cognitive behavioral therapy strategies, was effective in improving pain-related symptoms and anxiety symptoms compared to standard care. In follow-up, this current randomized clinical trial (RCT) aims to test potential neural mechanisms underlying the effect of ADAPT. Specifically, this two-arm RCT will explore changes in amygdalar functional connectivity (primary outcome) following the ADAPT protocol during the water loading symptom provocation task (WL-SPT). Secondary (e.g., changes in regional cerebral blood flow via pulsed arterial spin labeling MRI) and exploratory (e.g., the association between the changes in functional connectivity and clinical symptoms) outcomes will also be investigated. Methods We will include patients ages 11 to 16 years presenting to outpatient pediatric gastroenterology care at a midwestern children’s hospital with a diagnosis of FAPD plus evidence of clinical anxiety based on a validated screening tool (the Generalized Anxiety Disorder-7 [GAD-7] measure). Eligible participants will undergo baseline neuroimaging involving the WL-SPT, and assessment of self-reported pain, anxiety, and additional symptoms, prior to being randomized to a six-week remotely delivered ADAPT program plus standard medical care or standard medical care alone (waitlist). Thereafter, subjects will complete a post assessment neuroimaging visit similar in nature to their first visit. Conclusions This small scale RCT aims to increase understanding of potential neural mechanisms of response to ADAPT. Trial registration ClinicalTrials.gov registration: NCT03518216.

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Section: Methodsmentioning

confidence: 99%

Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

Cunningham,

Adler,

Barber Garcia

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a dim-light environment, a 12-minute rs-fMRI scan will be acquired while the subjects are asked to relax and have their eyes closed [26]. An eye-closed condition will likely be easier to maintain for our subjects [27,28]. Acquisition parameters: Isotropic voxel size of 2.5 × 2.5 × 2.5 mm 3 , 60 contiguous axial slices, FOV = 22 cm × 22 cm, TE = 30 ms, TR = 1100 ms, FA = 63°, 4 dummy time points discarded, 650 time points, and .…”

Section: Exploratory Outcomes (Collected At Pre and Post Assessments)mentioning

confidence: 99%

Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

Cunningham,

Adler,

Barber Garcia

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Background. Functional abdominal pain disorders (FAPD) are the most common chronic pain conditions of childhood and are made worse by co-occurring anxiety. Our research team found that the Aim to Decrease Pain and Anxiety Treatment (ADAPT), a six-session coping skills program using cognitive behavioral therapy strategies, was effective in improving pain-related symptoms and anxiety symptoms compared to standard care. In follow-up, this current randomized clinical trial (RCT) aims to test potential neural mechanisms underlying the effect of ADAPT. Specifically, this two-arm RCT will explore changes in amygdalar functional connectivity (primary outcome) following the ADAPT protocol during the water loading symptom provocation task (WL-SPT). Secondary (e.g., changes in regional cerebral blood flow via pulsed arterial spin labeling MRI) and exploratory (e.g., the association between the changes in functional connectivity and clinical symptoms) outcomes will also be investigated. Methods. We will include patients ages 11 to 16 years presenting to outpatient pediatric gastroenterology care at a midwestern children’s hospital with a diagnosis of FAPD plus evidence of clinical anxiety based on a validated screening tool (the Generalized Anxiety Disorder-7 [GAD-7] measure). Eligible participants will undergo baseline neuroimaging involving the WL-SPT, and assessment of self-reported pain, anxiety, and additional symptoms, prior to being randomized to a six-week remotely delivered ADAPT program plus standard medical care or standard medical care alone (waitlist). Thereafter, subjects will complete a post assessment neuroimaging visit similar in nature to their first visit. Conclusions. This small scale RCT aims to increase understanding of potential neural mechanisms of response to ADAPT. ClinicalTrials.gov registration:NCT03518216

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Structural and functional changes in the brain after chronic complete thoracic spinal cord injury

Li,

Shan,

Zhao

et al. 2024

Brain Research

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Functional connectivity of cortical resting-state networks is differentially affected by rest conditions

Cited by 5 publications

References 59 publications

Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

Study protocol for a pilot clinical trial to understand neural mechanisms of response to a psychological treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)

Structural and functional changes in the brain after chronic complete thoracic spinal cord injury

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