Functional connectivity of intercalated nucleus with medial amygdala: A circuit relevant for chemosignal processing

Biggs, Lindsey M.; Meredith, Michael

doi:10.1016/j.ibneur.2022.01.005

Cited by 3 publications

(1 citation statement)

References 57 publications

(103 reference statements)

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“…Rodent evidence has shown that the medial amygdala is a primary center for social communication processing; the medial amygdala receives chemosensory input from the main olfactory bulbs projecting to the basal forebrain to elicit appropriate behavioral and physiological responses 45 . One concept proposes that distortion is a characteristic of human memory and the memory errors can be adaptive for memory updating and exible behaviors, conversely, too rigid, robust, and undistorted memory may restrict the modi cation of thinking and behavior 46 .…”

Section: Discussionmentioning

confidence: 99%

Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm

King,

Li,

Qureshi

et al. 2023

Preprint

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Individuals with autism inconsistently exhibit increased or decreased volumes and functional connectivity of the whole amygdala and the whole hippocampus. Given heterogeneous structures of the amygdala and hippocampus and the heterogeneity of autism symptoms, it is worth examining how their subregions contribute to different autism phenotypes. T1-weighted and resting-state functional MRI data were acquired from 32 young adults of mothers who were pregnant during, or within 3 months of, the 1998 Quebec ice storm. Their broad autism phenotype was self-reported, including aloof personality, pragmatic language impairment and rigid personality. Volumes of the amygdala nuclei and hippocampal subfields were calculated. Seed-to-voxel analysis was applied to examine functional connectivity of the amygdala nuclei and hippocampal subfields with the rest of the brain, and linear regressions were implemented to examine associations of volume and functional connectivity with the three autism phenotypes. We found that 1) pragmatic language impairment was associated with increased right medial amygdala volume; 2) rigid personality was associated with decreased left hippocampal cornu ammonis (CA)1 volume; 3) pragmatic language impairment was associated with decreased left hippocampal CA1 connectivity with the supplementary motor area, and increased right hippocampal CA4 connectivity with the left putamen; and 4) rigid personality was associated with increased right central amygdala connectivity with the left inferior lateral occipital cortex (LOC); and increased left hippocampal CA3 connectivity with the right superior parietal lobule, increased right hippocampal CA4 connectivity with the left superior LOC, and increased right hippocampal dentate gyrus connectivity with the left superior LOC. In contrast, we found no associations with aloof personality. Our results suggest that amygdala and hippocampal structure and function contribute differently to two different autistic-like characteristics, with amygdala volume and hippocampus-motor connectivity explaining variance in communication impairment, and with hippocampal volume, amygdala- and hippocampus- sensory connectivity sharing the common mechanism in rigid behaviors.

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Section: Discussionmentioning

confidence: 99%

Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm

King,

Li,

Qureshi

et al. 2023

Preprint

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Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks

Aksoy-Aksel,

Ferraguti,

Holmes

et al. 2024

Nat Neurosci

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Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion

2022

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Generating adaptive behavioral responses to emotionally salient stimuli requires evaluation of complex associations between multiple sensations, the surrounding context, and current internal state. Neural circuits within the amygdala parse this emotional information, undergo synaptic plasticity to reflect learned associations, and evoke appropriate responses through their projections to the brain regions orchestrating these behaviors. Information flow within the amygdala is regulated by the intercalated cells (ITCs), which are densely packed clusters of GABAergic neurons that encircle the basolateral amygdala (BLA) and provide contextually relevant feedforward inhibition of amygdala nuclei, including the central and BLA. Emerging studies have begun to delineate the unique contribution of each ITC cluster and establish ITCs as key loci of plasticity in emotional learning. In this review, we summarize the known connectivity and function of individual ITC clusters and explore how different neuromodulators conveying internal state act via ITC gates to shape emotionally motivated behavior. We propose that the behavioral state-dependent function of ITCs, their unique genetic profile, and rich expression of neuromodulator receptors make them potential therapeutic targets for disorders, such as anxiety, schizophrenia spectrum, and addiction.

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Functional connectivity of intercalated nucleus with medial amygdala: A circuit relevant for chemosignal processing

Cited by 3 publications

References 57 publications

Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm

Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm

Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks

Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion

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