Functional connectivity of the hippocampus and its subfields in resting‐state networks

Ezama, Laura; Hernández‐Cabrera, Juan Andrés; Seoane, Sara; Pereda, Ernesto; Janssen, Niels

doi:10.1111/ejn.15213

Cited by 39 publications

(53 citation statements)

References 66 publications

(139 reference statements)

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“…Taking the structural and functional data together, the results reported here suggest that PA is associated with structural changes in the subiculum and CA1 subfields, and with functional changes in middle/posterior and anterior hippocampal clusters related to the default mode and somatomotor network, respectively. These observations make sense in light of previous high-spatial resolution functional connectivity studies (Ezama et al, 2021;Dalton et al, 2019;de Flores et al, 2017). These studies have shown that regions of the default mode network reliably co-activate with the presubiculum and subiculum subfields of the middle/posterior hippocampus, and that regions of the somatomotor network co-activate with the CA1 and CA3 regions of the anterior hippocampus.…”

Section: Discussionsupporting

confidence: 66%

“…In terms of the functional connectivity of the hippocampus with the rest of the brain, most previous studies have examined how PA affected the relationship between the hippocampus and the default mode network (Tao et al, 2016;Ikuta et al, 2019;Prakash et al, 2011;Esteban-Cornejo et al, 2021;Voss, Erickson, et al, 2010;Voss, Prakash, et al, 2010;Voss et al, 2016;Burdette et al, 2010;Boraxbekk et al, 2016;Weng et al, 2017). However, it is well-known that the hippocampus co-activates with at least two different whole-brain resting-state networks (Ezama et al, 2021;Kahn et al, 2008;Ranganath & Ritchey, 2012;Vincent et al, 2006). For example, Ezama et al (2021) found that during the resting-state, anterior sections of the hippocampus coactivated with brain regions typically associated with the somatomotor network, whereas middle/posterior sections of the hippocampus co-activated with brain regions typically associated with the default mode network.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is well-known that the hippocampus co-activates with at least two different whole-brain resting-state networks (Ezama et al, 2021;Kahn et al, 2008;Ranganath & Ritchey, 2012;Vincent et al, 2006). For example, Ezama et al (2021) found that during the resting-state, anterior sections of the hippocampus coactivated with brain regions typically associated with the somatomotor network, whereas middle/posterior sections of the hippocampus co-activated with brain regions typically associated with the default mode network. Thus, whereas previous studies have shown that PA affects the connectivity between the hippocampus and the default mode network (Kronman et al, 2020;Stillman et al, 2018;Raichlen et al, 2016), how PA is associated to the connectivity between the hippocampus and the somatomotor networks remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…We obtained volume estimates for the hippocampal subfields using automatic segmentation procedures (Iglesias et al, 2015). The functional connectivity analyses relied on an analysis approach previously developed in our laboratory (Ezama et al, 2021). We first performed Independent Component Analysis spatially restricted to the hippocampus (srICA; Blessing et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…We then examined the correlation between these group level maps and existing reference resting-state networks (Yeo et al, 2011). Based on previous studies, we expected to find an anterior cluster of activity inside the hippocampus that was connected with the somatomotor network, and a middle/posterior cluster that was connected with the default mode network (e.g., Ezama et al, 2021;Kahn et al, 2008Kahn et al, , 2008Prakash et al, 2011;Ranganath & Ritchey, 2012;Buckner & DiNicola, 2019). In the final step of our analyses we tested whether the functional connectivity of the activation clusters detected inside the hippocampus and their associated resting-state networks were modulated by different levels of PA in work, sports and leisure-time.…”

Section: Introductionmentioning

confidence: 99%

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Daily-life Physical Activity of Young Healthy Adults Associates with Function and Structure of the Hippocampus

Seoane¹,

Ezama²,

Janssen³

2021

Preprint

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Research on the impact of physical activity (PA) has shown that PA produces changes in the structure and function of a brain structure called the hippocampus. There are three main limitations in this research. First, the majority of the work has been carried out in elderly populations and as such, there is a paucity of research on the impact of PA on the brains of healthy young individuals. Second, whereas PA is typically assessed through controlled interventions, changes in the brain due to PA as performed during daily-life activities has not been explored. Finally, the hippocampus has a complex internal structure and the impact of PA on this internal structure is unclear. Here we examined how structural and functional aspects of the hip-pocampus are associated with habitual PA performed during work, leisure time and sports in the daily lives of young healthy adults. We found that PA performed during work time correlated with increased subicular volumes and with changed functional connectivity between a location in middle/posterior hippocampus and regions of the default mode network and between a location in anterior hippocampus and regions of the somatomotor network. No effects of PA performed during leisure time and sports were found. The results generalize the impact of PA to younger populations and show how PA performed in daily-life situations correlates with the precise internal structure of the hippocampus.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Daily-life Physical Activity of Young Healthy Adults Associates with Function and Structure of the Hippocampus

Seoane¹,

Ezama²,

Janssen³

2021

Preprint

Self Cite

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Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

et al. 2023

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Objectives : Bipolar disorder (BD) is a severe, chronic, affective disorder characterized by recurrent switching between mood states, psychomotor and cognitive symptoms, which can linger in euthymic states as residual symptoms. Hippocampal alterations may play a key role in the neural processing of BD symptoms. However, its dynamic functional connectivity (dFC) remains unclear. Therefore, the present study explores hippocampal dFC in relation to BD symptoms. Methods : We assessed hippocampus‐based dFC coactivation patterns (CAPs) on resting‐state fMRI data of 25 euthymic BD patients and 25 age‐ and sex‐matched healthy controls (HC). Results : Bilateral hippocampal dFC with somatomotor networks (SMN) was reduced in BD, compared to HC, while at the same time dFC between the left hippocampus and midcingulo‐insular salience system (SN) was higher in BD. Correlational analysis between CAPs and clinical scores revealed that dFC between the bilateral hippocampus and the default‐like network (DMN) correlated with depression scores in BD. Furthermore, pathological hyperconnectivity between the default mode network (DMN) and SMN and the frontoparietal network (FPN) was modulated by the same depression scores in BD. Conclusions : Overall, we observed alterations of large‐scale functional brain networks associated with decreased flexibility in cognitive control, salience detection, and emotion processing in BD. Additionally, the present study provides new insights on the neural architecture underlying a self‐centered perspective on the environment in BD patients. dFC markers may improve detection, treatment, and follow‐up of BD patients and of disabling residual depressive symptoms in particular.

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What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?

Berger,

Billig,

Sedley

et al. 2024

Human Brain Mapping

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The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by a number of studies. These structures are usually considered in the context of a “limbic system,” a concept typically invoked to explain the emotional response to tinnitus. Despite this common framing, it is not apparent from current literature that this is necessarily the main functional role of these structures in persistent tinnitus. Here, we highlight a different role that encompasses their most commonly implicated functional position within the brain—that is, as a memory system. We consider tinnitus as an auditory object that is held in memory, which may be made persistent by associated activity from the hippocampus and parahippocampal gyrus. Evidence from animal and human studies implicating these structures in tinnitus is reviewed and used as an anchor for this hypothesis. We highlight the potential for the hippocampus/parahippocampal gyrus to facilitate maintenance of the memory of the tinnitus percept via communication with auditory cortex, rather than (or in addition to) mediating emotional responses to this percept.

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Functional connectivity of the hippocampus and its subfields in resting‐state networks

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 39 publications

References 66 publications

Daily-life Physical Activity of Young Healthy Adults Associates with Function and Structure of the Hippocampus

Daily-life Physical Activity of Young Healthy Adults Associates with Function and Structure of the Hippocampus

Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?

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