Functional Connectivity Within and Between <i>n</i>-Back Modulated Regions: An Adult Lifespan Psychophysiological Interaction Investigation

Pongpipat, Ekarin E.; Kennedy, Kristen M.; Foster, C. M.; Boylan, Maria A.; Rodrigue, Karen M.

doi:10.1089/brain.2020.0791

Cited by 10 publications

(11 citation statements)

References 70 publications

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“…The main discrepancy between our results and previous studies is the limited effect of working memory load on connections within the default mode network and connectivity between this network and other networks (Eryilmaz et al, 2020; Liang et al, 2016; Pongpipat et al, 2021). Pongpipat et al (2021) reported an increase in negative connectivity between the frontoparietal and default mode network as load increased. This effect was stronger when comparing task with a control condition than for the linear effect of load.…”

Section: Discussioncontrasting

confidence: 99%

“…A limited number of studies have investigated the effects of age on working memory load-modulated functional connectivity. Pongpipat and colleagues (2021) showed that functional connectivity within frontoparietal and default mode regions was strengthened as working memory load increased. With increasing load, the negative connectivity between the frontoparietal and default mode network also increased.…”

Section: Introductionmentioning

confidence: 99%

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Lifespan differences in visual short-term memory load-modulated functional connectivity

Lugtmeijer

Geerligs

Tsvetanov

et al. 2022

Preprint

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Working memory is critical to higher-order executive processes and declines throughout the adult lifespan. However, our understanding of the neural mechanisms underlying this decline is limited. Recent work suggests that functional connectivity between frontal control and posterior visual regions may be critical, but examinations of age differences therein have been limited to a small set of brain regions and extreme group designs (i.e., comparing young and older adults). In this study, we build on previous research by using a lifespan cohort and a whole-brain approach to investigate working memory load-modulated functional connectivity in relation to age and performance. The article reports on analysis of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data. Participants from a population-based lifespan cohort (N=111, age 23-86) performed a visual short-term memory task during functional magnetic resonance imaging. Visual short-term memory was measured with a delayed recall task for visual motion with three different loads. Whole-brain load-modulated connectivity was estimated using psychophysiological interactions in a hundred regions of interest, sorted into seven networks (Schaefer et al., 2018, Yeo et al., 2011). Results showed that load-modulated functional connectivity was strongest within the dorsal attention network followed by the visual network during encoding and maintenance. With increasing age, load-modulated functional connectivity strength decreased throughout the cortex. Within the dorsal attention network, increased load-modulated connectivity strength was related to better task performance in an age-invariant way. Our results demonstrate the widespread negative impact of age on the modulation of functional connectivity by working memory load. Older adults might already be close to ceiling in terms of their resources at the lowest load and therefore less able to further increase connectivity with increasing task demands.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lifespan differences in visual short-term memory load-modulated functional connectivity

Lugtmeijer

Geerligs

Tsvetanov

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…However, results are more inconsistent for task-related changes in functional connectivity with age. Across a range of cognitive tasks, studies reported a similar pattern as for resting state investigations (Geerligs et al, 2014; Spreng et al, 2016), no changes for within-but only for between-network connectivity (Gallen et al, 2016; Grady et al, 2016), as well as age invariance (Pongpipat et al, 2020; Trelle et al, 2019). In the domain of semantic cognition, findings are sparse with one study observing reduced within-network integration for a semantic fluency task which was not associated with a poorer performance in older adults (Marsolais et al, 2014).…”

Section: Discussionsupporting

confidence: 53%

“…We conducted psychophysiological interaction (PPI) analyses using the gPPI toolbox for SPM12 (McLaren et al, 2012) to investigate task-related modulation of functional connectivity associated with the semantic fluency and the counting task. Furthermore, we applied a modified version of gPPI methods to examine functional connections between individual ROIs during the semantic fluency task (Pongpipat et al, 2020). Seed regions were defined for all previously identified global maxima that were located within the MDN and the DMN (Table 3).…”

Section: Methodsmentioning

confidence: 99%

Age-dependent contribution of domain-general networks to semantic cognition

Martin

Saur

Hartwigsen

2020

Preprint

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Aging is characterized by a decline of cognitive control. In semantic cognition, this leads to the paradox that older adults usually show poorer task performance than young adults despite their greater semantic knowledge. So far, the underlying neural changes of these behavioral differences are poorly understood. In the current neuroimaging study, we investigated the interplay of domain-specific and domain-general networks in young and older adults during a verbal semantic fluency task. In both age groups, task processing was characterized by a strong interaction between the domain-general multiple-demand and the default mode system during semantic fluency. However, the behavioral relevance of strengthened connectivity differed between groups: While within- and between-network functional connectivity predicted better performance in young adults, these increases were associated with a performance decline in older adults. Our findings lend novel support to the notion of reduced efficiency in the aging brain, due to neural dedifferentiation in semantic cognition.

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“…However, their behavioral relevance seems to depend on the cognitive resources required for the task of interest. Research from domains well known to steadily decline with age, such as episodic and working memory, reported compensational recruitment of control and attention networks for successful performance 21,24,25 but also maintenance processes with age to preserve neural resources despite structural deterioration 26,27 . A different picture emerges for cognitive abilities that remain stable with age like language and creativity.…”

Section: Introductionmentioning

confidence: 99%

Age-related reorganization of functional network architecture in semantic cognition

Martin

Williams

Saur

et al. 2022

Preprint

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Cognitive aging is associated with widespread neural reorganization processes in the human brain. However, the behavioral impact of such reorganization is not well understood. The current neuroimaging study investigated age differences in the functional network architecture during language production. Combining task-based functional connectivity, graph theory and cognitive measures of fluid and crystallized intelligence, our findings show age-accompanied large-scale network reorganization even when older adults have intact word retrieval abilities. In particular, functional networks of older adults were characterized by reduced decoupling between systems, reduced segregation and efficiency, and a larger number of hub regions relative to young adults. Exploring the predictive utility of these age-related changes in network topology revealed high, albeit less efficient, performance for older adults whose brain graphs showed stronger dedifferentiation and reduced distinctiveness. Our results have important implications for theoretical accounts of neurocognitive aging, indicating a successful compensatory network reconfiguration at the cost of efficient wiring.

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Functional Connectivity Within and Between n-Back Modulated Regions: An Adult Lifespan Psychophysiological Interaction Investigation

Cited by 10 publications

References 70 publications

Lifespan differences in visual short-term memory load-modulated functional connectivity

Lifespan differences in visual short-term memory load-modulated functional connectivity

Age-dependent contribution of domain-general networks to semantic cognition

Age-related reorganization of functional network architecture in semantic cognition

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