Functional constipation symptoms and complementary feeding methods: A randomized clinical trial

Neves, Renata Oliveira; Nunes, Leandro Meirelles; Silveira, Larissa de Oliveira; Lima, Marcela Reckziegel; Moreira, Paula Ruffoni; Bernardi, Juliana Rombaldi

doi:10.1016/j.anpede.2023.01.011

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Функціональні закрепи посідають вагоме місце в структурі функціональних розладів травного тракту, їхня частота сягає 14,4% [23], причому втричі частіше вони відмічаються в дітей раннього віку. Нерідко симптоми з'являються впродовж першого року життя, коли відбуваються значні зміни в харчуванні немовляти, зокрема, введення продуктів прикорму та раннє переривання грудного вигодовування [11,16]. Розподіл частоти функціональних закрепів серед хлопчиків і дівчаток є приблизно однаковим [4].…”

Section: Methodsunclassified

Improving an integrated approach to the treatment of functional constipation in children

Krycky,

Hoshchynskyi,

Shulhai

et al. 2023

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Functional constipation in children has become a serious medical issue that needs to be addressed immediately. They can significantly limit children’s physical activity and social integration, which emphasizes the importance of providing them with effective care. Purpose - to analyze and improve the results of the complex use of a lactulose-based drug and prophylactic phytocylinders with a lipophilic complex of rose hips and chamomile extract in the treatment of functional constipation in children. Materials and methods. We examined 78 children with constipation over the past 3 years. They were divided into two groups. The first group included 36 (46.2%) patients, the second - 42 (53.8%). Patients of the first group received standard treatment according to the protocols of the Ministry of Health of Ukraine, patients of the second group received similar treatment and additionally lactulose in the form of syrup and a preparation based on prophylactic phytocylinders with a lipophilic complex of rose hips and chamomile extract during the course of treatment daily in the form of rectal suppositories. Results. Most patients were female (60.2%), had average physical development parameters. The duration of constipation ranged from 1 to 3 months, and stool retention - from 3 to 5 days. At the beginning of the observation, there were complaints of changes in the shape and consistency of stools, painful defecation, flatulence, periodic abdominal pain, strong straining during defecation, fear or anxiety in children before the act of defecation. An analysis of anamnestic data showed that in one third of patients, constipation was observed during the transition from breastfeeding to artificial feeding. Conclusions. The analysis of the addition to the complex of treatment of functional constipation, in addition to lactulose, of preparations based on prophylactic phytocylinders with a lipophilic complex of rose hips and chamomile extract is a safe and quite effective method of correcting these disorders in young children, as evidenced by the results obtained. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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Section: Methodsunclassified

Improving an integrated approach to the treatment of functional constipation in children

Krycky,

Hoshchynskyi,

Shulhai

et al. 2023

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“…Substantial current evidence suggests that the gut microbiome, bile secretion, lifestyle, and behavioral psychology are all factors in uencing constipation. (Cha et al 2023; Erhardt et al 2023;Neves et al 2023; Wang et al 2023). Central to intestinal well-being and digestion is the gut microbiome-a rich ecosystem of microorganisms such as bacteria, fungi, and viruses that inhabit the human gastrointestinal tract (Wu et al 2024).…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between Eubacterium and constipation: a Mendelian randomization study

Fan,

Zhang,

Liu

et al. 2024

Preprint

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Background: Constipation may be related to an imbalance in flora imbalance. In this study, univariate and multivariate Mendelian randomization (MR) studies were used to further understand the causal relationship between different members of genus Eubacteriumand constipation. Methods: The constipation and genus Eubacterium datasets were obtained from the Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Study (GWAS) database. The causal effects between constipation and genus Eubacterium were analyzed using MR-Egger, Weighted median, Simple mode, Weighted mode and Inverse variance weighted (IVW). In univariate MR analysis (UVMR), genus Eubacillus was the exposure factor, constipation was the outcome. In addition, the reliability of UVMR analysis was assessed by sensitivity analyses (heterogeneity tests, horizontal pleiotropy tests and leave-one-out (LOO) analysis). Finally, the MVMR analysis was performed. Results: In the UVMR analysis, genus Eubacterium rectale group id.14374 (p=0.043, OR=0.805) and genus Eubacterium brachy group id.11296 (p=0.036, OR=0.904) were all protective factors on constipation. The results of sensitivity analysis showed that UVMR analysis was reliable. In the MVMR analysis, genus Eubacterium rectalegroup was still a significant protective factor (p=0.007, OR=0.80), while genus Eubacterium brachy group was not a significant protective factor for constipation (p=0.151, OR=0.94) . Conclusion: The results of study supported that genus Eubacterium rectale group had a significant causal relationship with constipation, and the increase of genus Eubacterium rectale group could reduce the risk of constipation.

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Functional constipation symptoms and complementary feeding methods: A randomized clinical trial

Cited by 2 publications

References 19 publications

Improving an integrated approach to the treatment of functional constipation in children

Improving an integrated approach to the treatment of functional constipation in children

The causal relationship between Eubacterium and constipation: a Mendelian randomization study

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