2021
DOI: 10.1002/dvdy.316
|View full text |Cite
|
Sign up to set email alerts
|

Functional contribution of DCLKs in sea urchin development

Abstract: Background Doublecortin‐like kinase1 and 2 (DCLKs) are protein Ser/Thr kinases important for neuronal development. More recently, they are also reported to regulate plasticity such as cell proliferation and differentiation of stem cells and cancer cells, but the details of their functions in this biological context are still unclear. With an attempt to reveal the functions of DCLKs in plasticity regulation, we here used the sea urchin embryo that undergoes highly regulative development as an experimental model… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1
1

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(1 citation statement)
references
References 22 publications
0
1
0
Order By: Relevance
“…In Caenorhabditis elegans , the Dclk gene zyg-8 is required for microtubule assembly at the mitotic spindle of zygotes [ 41 ] and later during development as a regulator of microtubules mainly in neurons [ 42 ]. In sea urchin, two Dclk genes are expressed uniformly throughout the embryo [ 43 ]. Microtubule-binding Dcx domains thus emerged prior to the origin of metazoans, but it remains unclear at which point in evolution Dcx-domain proteins became important for the development of neural cells.…”
Section: Introductionmentioning
confidence: 99%
“…In Caenorhabditis elegans , the Dclk gene zyg-8 is required for microtubule assembly at the mitotic spindle of zygotes [ 41 ] and later during development as a regulator of microtubules mainly in neurons [ 42 ]. In sea urchin, two Dclk genes are expressed uniformly throughout the embryo [ 43 ]. Microtubule-binding Dcx domains thus emerged prior to the origin of metazoans, but it remains unclear at which point in evolution Dcx-domain proteins became important for the development of neural cells.…”
Section: Introductionmentioning
confidence: 99%