Functional Contributions of the Arcuate Fasciculus to Language Processing

Ivanova, Maria V.; Zhong, Allison; Turken, And U.; Baldo, Juliana V.; Dronkers, Nina F.

doi:10.3389/fnhum.2021.672665

Cited by 66 publications

(72 citation statements)

References 73 publications

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“…For example, damage to the anterior aspect of the IFG reduced syntactic accuracy during production in acute stroke 5 and has been associated with qualitative assessments of agrammatic speech in chronic stroke. 10 In chronic stroke, the long segment of AF is necessary for syntactic processing for sentence production 67 and comprehension 68 supporting the association we observed at the late chronic stage between the long segment of AF and degree of syntax recovery. In contrast, the posterior AF segment is not associated with frontal cortical regions as it connects the middle temporal gyrus with the angular gyrus.…”

Section: Acute White Matter Tract Damage and Connected Speech Recoverysupporting

confidence: 71%

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Anterior Connectivity Critical for Recovery of Connected Speech after Stroke

Ding

Schnur

2022

Preprint

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Connected speech recovers to different degrees across people after left hemisphere stroke, but white matter predictors of differential recovery from the acute stage of stroke are unknown. We assessed changes in lexical-syntactic aspects of connected speech in a longitudinal analysis of 41 individuals (19 females) from the acute stage of LH stroke (within an average 4 days post-stroke) to subacute (within 2 months) and chronic stages (early: 6 months, late: 1 year) while measuring the extent of acute lesions on white-matter tracts to identify tracts predictive of recovery. We found that acute damage to the frontal aslant tract led to decreased recovery of the fluency and structural complexity of connected speech during the year following left hemisphere stroke. In addition, acute damage of the frontal aslant tract and the posterior and long segments of the arcuate fasciculus negatively impacted the recovery of syntactic accuracy, although the associations did not survive correction for multiple comparisons. Results were independent of baseline performance, overall lesion volume, and the proportion damage to tract-adjacent gray matter. This longitudinal analysis from acute to chronic stroke provides the first evidence that recovery of fluent and structurally complex spontaneous connected speech requires intact left frontal connectivity via the frontal aslant tract. That the frontal aslant tract was critical for recovery at early as well as later stages of stroke demonstrates that anterior connectivity plays a lasting and important role for the reorganization of function related to the successful production of connected speech.

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Section: Acute White Matter Tract Damage and Connected Speech Recoverysupporting

confidence: 71%

“…Although lesion volume often predicts language deficit severity in stroke (e.g. 6,19,34,36,67,70,71 ; cf. 18 ), lesion volume does not predict the degree of general language 72 or domain-specific cognitive function 73 recovery.…”

Section: Other Predictors Of Connected Speech Recoverymentioning

confidence: 99%

Anterior Connectivity Critical for Recovery of Connected Speech after Stroke

Ding

Schnur

2022

Preprint

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“…The AF constitutes the long segment of the dorsal language pathway (Catani and Dawson, 2017). It connects superior temporal gyrus and inferior frontal gyrus, and is important for naming abilities (Ivanova et al, 2021), word repetition (Sierpowska et al, 2017) and reading (Gullick and Booth, 2015; Thiebaut De Schotten et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

“…With the methods we employed, all segments were captured as a single tract (Yeatman et al, 2012). Relevant to the inquiries posed in this study, one segment (SLF III) constitutes the anterior segment of the dorsal language pathway (Catani and Dawson, 2017), which has a role in fluency and naming (Ivanova et al, 2021). It connects supramarginal gyrus to inferior frontal gyrus (Yagmurlu et al, 2016), two regions involved in reading and reading-related processes (Eden et al, 2016).…”

Section: Automated Fiber Quantificationmentioning

confidence: 99%

Home literacy environment mediates the relationship between socioeconomic status and white matter structure in infants

Turesky¹,

Sanfilippo

Zuk

et al. 2021

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The home literacy environment (HLE) in infancy has been associated with subsequent pre-literacy skill development and HLE at pre-school age has been shown to correlate with white matter organization in tracts that subserve prereading and reading skills. Furthermore, childhood socioeconomic status (SES) has been linked with both HLE and white matter organization. It is also important to understand whether the relationships between environmental factors such as HLE and SES and white matter organization can be detected as early as infancy, as this period is characterized by rapid brain development that may make white matter pathways particularly susceptible to these early experiences. Here, we hypothesized (1) an association between HLE and white matter organization in pre-reading and reading-related tracts in infants, and (2) that this association mediates a link between SES and white matter organization. To test these hypotheses, infants (mean age: 9.2 ± 2.5 months, N = 18) underwent diffusion-weighted imaging MRI during natural sleep. Fractional anisotropy (FA) was estimated from the left superior longitudinal fasciculus (SLF) and left arcuate fasciculus using the automated fiber-tract quantification method. HLE was measured with the Reading subscale of the StimQ and SES was measured with years of maternal education. Self-reported maternal reading ability was also quantified and applied to all statistical models to control for confounding genetic effects. The Reading subscale of the StimQ positively related to FA in left SLF and mediated the association between maternal education and FA in the left SLF. Taken together, these findings underscore the importance of considering HLE from the start of life and may inform novel prevention and intervention strategies targeted at low-SES families to support developing infants during a period of heightened brain plasticity.

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“…'s language-relevant tracts was severely damaged, encompassing left dorsal (fronto-temporal and fronto-parietal sections of the AF) and left ventral tracts (IFOF, ILF and UF) as well as FAT. A (recent) body of research supports the notion that these tracts are relevant for various aspects of language function (e.g., Dick et al, 2019;Ivanova et al, 2021;Sierpowska et al, 2019;for review, Dick & Tremblay, 2012). Importantly, the posterior temporal lobe and TPJ and underlying white matter, all damaged in A.…”

Section: Behavioural and Structural Findingsmentioning

confidence: 96%

Time-course of right-hemisphere recruitment during word production following lefthemisphere damage: A single case of young stroke

Chupina¹,

Sierpowska²,

Zheng³

et al. 2021

Preprint

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Our understanding of post-stroke language recovery and underlying neuroplasticity is largely based on older age groups, who have increasing brain pathology and potentially more bilateral language functioning. We present the case of A., a 23 y.o. woman with chronic aphasia from a left-hemisphere stroke. Deterministic tractography indicated that A.’s language-relevant white matter structures were severely damaged. Using magnetoencephalography (MEG), we explored A.’s conceptual preparation and subsequent word planning abilities. Context-driven and Bare picture-naming tasks revealed substantial naming deficits, manifesting as word-finding difficulties and semantic paraphasias about half of the time. Naming was however facilitated by semantically constraining lead-in sentences. Altogether, this pattern indicates intact conceptual preparation but disrupted lexical and phonological retrieval abilities. MEG revealed that A.’s naming-related neural responses differed from that of a matched control. Source localisation showed active but differential recruitment of right-hemisphere structures (300-400 ms post-picture onset) during both correct naming (right temporo-parietal regions) and anomic (right inferior frontal gyrus) attempts. We consider that, despite A.’s young age, the presumed strong degree of language lateralisation and extensive structural damage limited her recovery. Although A.’s right hemisphere responded in a timely manner during word planning, its lexical and phonological retrieval abilities remained modest.

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Functional Contributions of the Arcuate Fasciculus to Language Processing

Cited by 66 publications

References 73 publications

Anterior Connectivity Critical for Recovery of Connected Speech after Stroke

Anterior Connectivity Critical for Recovery of Connected Speech after Stroke

Home literacy environment mediates the relationship between socioeconomic status and white matter structure in infants

Time-course of right-hemisphere recruitment during word production following lefthemisphere damage: A single case of young stroke

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