Functional correlates of musical and visual ability in frontotemporal dementia

Miller, Bruce L.; Boone, Kyle Brauer; Cummings, Jeffrey L.; Read, Stephen L.; Mishkin, Fred S.

doi:10.1192/bjp.176.5.458

Cited by 238 publications

(156 citation statements)

References 29 publications

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“…Furthermore, bilateral activation might indicate increased interhemispheric transfer. While some have argued that creativity is solely a function of the right hemisphere [Finkelstein et al, 1991;Miller et al, 1996Miller et al, , 1998Miller et al, , 2000Murai et al, 1998;Rotenberg, 1994], others have argued that both hemispheres are involved and that interrelations between the two hemispheres are the key to creative insight [Atchley et al, 1999;Bogen and Bogen, 1969;Kwong et al, 1992]. Our data support the latter view.…”

Section: Early Bilateral Insula Activation For Insight Solutionssupporting

confidence: 81%

“Aha!”: The neural correlates of verbal insight solutions

Aziz‐Zadeh

Kaplan

Iacoboni

2008

Human Brain Mapping

167

119

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What are the neural correlates of insight solutions? To explore this question we asked participants to perform an anagram task while in the fMRI scanner. Previous research indicates that anagrams are unique in that they can yield both insight and search solutions in expert subjects. Using a single-trial fMRI paradigm, we utilized the anagram methodology to explore the neural correlates of insight versus search solutions. We used both reaction time measures and subjective reports to classify each trial as a search or insight solution. Data indicate that verbal insight solutions activate a distributed neural network that includes bilateral activation in the insula, the right prefrontal cortex, and the anterior cingulate. These areas are discussed with their possible role in evaluation and metacognition of insight solutions, as well as attention and monitoring during insight.

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Section: Early Bilateral Insula Activation For Insight Solutionssupporting

confidence: 81%

“Aha!”: The neural correlates of verbal insight solutions

Aziz‐Zadeh

Kaplan

Iacoboni

2008

Human Brain Mapping

167

119

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“…Likewise, cases of artists affected by dementia whose skills were preserved for a long time during their illness, even after other cognitive functions presented severe deficits, have been documented (Cummings, Miller, Christensen, & Cherry, 2008;Fornazzari, 2005). There are also documented cases of people with neurodegenerative diseases who have developed artistic interests and skills they did not have prior to their illness (Bruce L. Miller, Boone, Cummings, Read, & Mishkin, 2000;Miller et al, 1998). As mentioned earlier, painting is an activity in which people with AD can show development.…”

Section: Discussionmentioning

confidence: 99%

Art galleries, episodic memory and verbal fluency in dementia: An exploratory study.

Eekelaar

Camic

Springham

2012

Psychology of Aesthetics, Creativity, and the Arts

138

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Abstract. The goal of this study was to determine whether experts attribute a series of images created by people with dementia who were participating in a program of contemporary art education to artists or to people without prior artistic experience. In this way, we sought to obtain an indicator of the artistic quality of the images produced by people with dementia. Participants were 122 specialists in art to whom were presented 30 images, 15 works by professional artists and 15 created by people with dementia. For each of the 15 images created by the people with dementia, we calculated the proportion of experts who attributed the image to a professional artist. The results indicated that, in a significant number of cases, which varied according to the images, the experts attributed the images to professional artists. The judgment of the experts reinforcing the idea of the creative potential of people with dementia. Keywords: Art; dementia; artists; creativity.[es] Creatividad artística y demencia. Un estudio de evaluación por expertos Resumen. El objetivo de este estudio fue determinar si expertos atribuían a artistas o a personas sin experiencia artística previa una serie de imágenes creadas por personas con demencia que participaban en un programa de educación artística contemporánea. De esta manera, buscamos obtener un indicador de la calidad artística de las imágenes producidas por personas con demencia. Participaron en el trabajo 122 especialistas en arte a los que se presentaron 30 imágenes, 15 obras de artistas profesionales y 15 creadas por personas con demencia. Para cada una de las 15 imágenes creadas por las personas con demencia, calculamos la proporción de expertos que atribuyeron la imagen a un artista profesional. Los resultados indicaron que, en un número significativo de casos, que variaron según las imágenes, los expertos atribuyeron las imágenes a artistas profesionales. El juicio de los expertos refuerza la idea del potencial creativo de las personas con demencia.

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“…Pobric et al (2007) argue that it is central to processing semantic information. Several studies of acquired semantic dementia show damage to the ATLs, predominantly on the left side (Miller et al, 2000;Miller et al, 1998;Treffert, 2006). Relatedly, there is evidence that inhibiting this area via rTMS reduces a person's reliance on concepts or schemas (Pobric et al, 2007;).…”

Section: Discussionmentioning

confidence: 99%

Noninvasive brain stimulation reduces prejudice scores on an implicit association test.

Gallate¹,

Wong²,

Ellwood³

et al. 2011

Neuropsychology

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Objective: Inhibiting the anterior temporal lobe (ATL) via repetitive transcranial magnetic stimulation (rTMS) appears to have deleterious effects on people's semantic conceptualization, and left ATL damage is associated with semantic dementia. However, little research has investigated whether rTMS can inhibit conceptual schemata that have potentially negative consequences. Our aim was to investigate whether rTMS to the ATLs could reduce scores on a standard measure of prejudice (implicit association test, IAT). Method: Forty (17 female; mean age 20.6) neurologically normal, right-handed undergraduates participated. Participants were randomly allocated into one of four rTMS stimulation conditions-left ATL, right ATL, control site (motor cortex, Cz), and sham stimulation. All participants completed a modified IAT, where "good" and "bad" words were replaced with "terrorist" and "law-abider" words, and, "Black" and "White" were replaced with "Arab" and "Non-Arab" words. Participants were then given 15 min of rTMS stimulation. Afterward, participants completed a parallel form of the IAT. Results: To investigate the effects of rTMS on IAT scores, a one-way ANOVA on the difference between pre-and postscores was carried out revealing that there were significant between group differences (F3,36 ϭ 3.57; p ϭ .02). Planned contrasts revealed that both left and right ATL stimulation significantly reduced IAT scores poststimulation, indicating lower prejudice. Conclusion: We show that prejudice scores can be significantly reduced by inhibitory rTMS delivered to the bilateral ATLs. This may implicate this area in conceptual associations that lead to overgeneralization and stereotyping of social groups.

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Functional correlates of musical and visual ability in frontotemporal dementia

Abstract: Loss of function in the left anterior temporal lobe may lead to facilitation of artistic or musical skills. Patients with the left-sided temporal lobe variant of FTD offer an unexpected window into the neurological mediation of visual and musical talents.

Cited by 238 publications

References 29 publications

“Aha!”: The neural correlates of verbal insight solutions

“Aha!”: The neural correlates of verbal insight solutions

Art galleries, episodic memory and verbal fluency in dementia: An exploratory study.

Noninvasive brain stimulation reduces prejudice scores on an implicit association test.

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