Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells

Wu, Pei; Lin, Yu-Chia; Chang, Chia‐Yi; Lu, H.T.; Chin, Chia-Hsuan; Hsu, Tsan-Ting; Chu, Dachen; Sun, Synthia H.

doi:10.1016/j.cellsig.2009.01.036

Cited by 79 publications

(69 citation statements)

References 40 publications

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“…On the other hand, retinoic acid (RA) induces neuronal differentiation and down-regulates P2X 7 receptor expression in human SH-SY5Y neuroblastoma cells, thus protecting them from extracellular nucleotide-P2X 7 receptorinduced neuronal death [134]. Similar results were obtained in the case of Neuro-2a cells, where RA-induced neuronal differentiation associated with decreased expression and function of P2X 7 receptors [135]. Together, these evidences suggest that retinoids can transcriptionally regulate the expression and function of P2 receptors, at least, in the skin and nervous system.…”

Section: P2 Receptors and Steroid Hormone Receptorssupporting

confidence: 71%

Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

Bilbao

Katz

Boland

2011

Purinergic Signalling

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Extracellular purines and pyrimidines have emerged as key regulators of a wide range of physiological and pathophysiological cellular processes acting through P1 and P2 cell surface receptors. Increasing evidence suggests that purinergic receptors can interact with and/or modulate the activity of other classes of receptors and ion channels. This review will focus on the interactions of purinergic receptors with other GPCRs, ion channels, receptor tyrosine kinases, and steroid hormone receptors. Also, the signal transduction pathways regulated by these complexes and their new functional properties are discussed.

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Section: P2 Receptors and Steroid Hormone Receptorssupporting

confidence: 71%

Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

Bilbao

Katz

Boland

2011

Purinergic Signalling

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“…26,27) In these investigations, we used N2a cells derived from spontaneous neuroblastoma of mouse, which are capable of differentiation into neuronal-like cells. 28) ChAT and VAChT proteins are only synthesized in cholinergic cells in the nervous system and their expression is tightly linked. 29) In this regard, we demonstrated that MAP-2, a neuronal differentiation marker, and the nerve growth factor receptor (p75), a surface marker for mature basal forebrain cholinergic neurons, were specifically induced by Re and Rd treatment.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Re and Rd Enhance the Expression of Cholinergic Markers and Neuronal Differentiation in Neuro-2a Cells

Kim

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Six homomeric (P2X 1À5 and P2X 7 ) and six heteromeric (P2X 1/2 , P2X 1/4 , P2X 1/5 , P2X 2/3 , P2X 2/6 and P2X 4/6 ) receptors have been described. The homomeric P2X 7 receptor is an atypical purinergic receptor with a longer carboxy-terminal tail and a number of polymorphisms or spliced variants (Gunosewoyo et al, 2007;Wu et al, 2009). The activation of P2X 7 receptors is highly regulated by extracellular levels of ATP.…”

Section: Atp Receptorsmentioning

confidence: 99%

Extracellular adenosine triphosphate and adenosine in cancer

2010

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Adenosine triphosphate (ATP) is actively released in the extracellular environment in response to tissue damage and cellular stress. Through the activation of P2X and P2Y receptors, extracellular ATP enhances tissue repair, promotes the recruitment of immune phagocytes and dendritic cells, and acts as a co-activator of NLR family, pyrin domain-containing 3 (NLRP3) inflammasomes. The conversion of extracellular ATP to adenosine, in contrast, essentially through the enzymatic activity of the ecto-nucleotidases CD39 and CD73, acts as a negativefeedback mechanism to prevent excessive immune responses. Here we review the effects of extracellular ATP and adenosine on tumorigenesis. First, we summarize the functions of extracellular ATP and adenosine in the context of tumor immunity. Second, we present an overview of the immunosuppressive and pro-angiogenic effects of extracellular adenosine. Third, we present experimental evidence that extracellular ATP and adenosine receptors are expressed by tumor cells and enhance tumor growth. Finally, we discuss recent studies, including our own work, which suggest that therapeutic approaches that promote ATP-mediated activation of inflammasomes, or inhibit the accumulation of tumorderived extracellular adenosine, may constitute effective new means to induce anticancer activity.

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Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells

Cited by 79 publications

References 40 publications

Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function

Ginsenoside Re and Rd Enhance the Expression of Cholinergic Markers and Neuronal Differentiation in Neuro-2a Cells

Extracellular adenosine triphosphate and adenosine in cancer

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