Abstract:Fiber technology has stepped into an essential position in the textile industry. It is forecasted that smart textiles will keep on developing constantly and vigorously. Having a convenient drug delivery system for treating various illnesses and bacterial infections is always in demand. Hollow fibers, which consist of a hollow structure and exceptional characteristics, such as high loading capacity and high surface reactivity, have been considerably used in medical equipment. A pilot study was performed in this… Show more
“…It was observed that drugs in either liquid phase (with the use of anti-cancer medicine, such as 5-FU) or crystal solid phase (with the use of Chinese medicinal herbs called Borneol or Bing Pian) could be successfully loaded into the channels of the hollow fibers. 16 The drug loading method under negative pressure (vacuum), which was known for assisting in pulling water upward inside the lumens based on the capillary action, 18 was verified. For the application of vacuum suction, an appropriate suction flow rate could be generated so as to extract the air out of the internal lumens of the hollow fibers.…”
Section: Microscopic Analysis Of the Drug Loading Capabilitymentioning
confidence: 99%
“…To confirm the feasibility of the proposed self-care textile wearable, the inner drug delivery layer and the thermal distribution of the middle thermal conductive e-fabric layer were studied. This is quite a versatile method for loading drugs in the bores of hollow fibers 16,17 and that with non-woven fabrication. Wearable conductive materials were also fabricated into the hollow fiber-based non-woven fabrics for the thermal imaging of the self-heating function.…”
Fiber technology has become increasingly essential in various industries, such as the fashion clothing, medical, cosmetic and upholstery industries. It can be used to overcome some existing challenges of textile-skin interaction in response to medical functions. This research aims to study the thermal-stimuli effects and biological performances of drug delivery textiles so as to develop a personal self-care textile that is wearable for a wide range of adaptive medical treatments. The proposed study is interdisciplinary and focuses on the following: (1) developing a long-term continuous self-care drug delivery textile wearable for patients by using different textile materials and structure layering; (2) examining the loading capability of synthetic staple crimped hollow fibers in the assembly of the non-woven structure; (3) comparing the drug loading performance between direct infiltration with magnetic stirring and vacuum loading; (4) observing the thermal distribution of the thermal-stimuli drug delivery textile layers. Designing a specially made textile wearable for breast cancer patients (i.e. a bra for females and a sweatshirt/pullover for males) is a conceptual example of the proposed self-care textile wearable. Silver-coated conductive yarns were fabricated into hollow fiber-based non-woven fabrics for thermal stimulation. Significant drug delivery through the non-wovens was shown by the anti-breast cancer analysis. Drugs in different phases, liquid and crystal solid, could be carried by the lumens of the hollow fibers. If the proposed study is successfully commercialized, it will be a great technological breakthrough in preparing a future generation of drug delivery medical textiles. A variety of medical applications can hence be provided and it could also be an alternative for topical healthcare.
“…It was observed that drugs in either liquid phase (with the use of anti-cancer medicine, such as 5-FU) or crystal solid phase (with the use of Chinese medicinal herbs called Borneol or Bing Pian) could be successfully loaded into the channels of the hollow fibers. 16 The drug loading method under negative pressure (vacuum), which was known for assisting in pulling water upward inside the lumens based on the capillary action, 18 was verified. For the application of vacuum suction, an appropriate suction flow rate could be generated so as to extract the air out of the internal lumens of the hollow fibers.…”
Section: Microscopic Analysis Of the Drug Loading Capabilitymentioning
confidence: 99%
“…To confirm the feasibility of the proposed self-care textile wearable, the inner drug delivery layer and the thermal distribution of the middle thermal conductive e-fabric layer were studied. This is quite a versatile method for loading drugs in the bores of hollow fibers 16,17 and that with non-woven fabrication. Wearable conductive materials were also fabricated into the hollow fiber-based non-woven fabrics for the thermal imaging of the self-heating function.…”
Fiber technology has become increasingly essential in various industries, such as the fashion clothing, medical, cosmetic and upholstery industries. It can be used to overcome some existing challenges of textile-skin interaction in response to medical functions. This research aims to study the thermal-stimuli effects and biological performances of drug delivery textiles so as to develop a personal self-care textile that is wearable for a wide range of adaptive medical treatments. The proposed study is interdisciplinary and focuses on the following: (1) developing a long-term continuous self-care drug delivery textile wearable for patients by using different textile materials and structure layering; (2) examining the loading capability of synthetic staple crimped hollow fibers in the assembly of the non-woven structure; (3) comparing the drug loading performance between direct infiltration with magnetic stirring and vacuum loading; (4) observing the thermal distribution of the thermal-stimuli drug delivery textile layers. Designing a specially made textile wearable for breast cancer patients (i.e. a bra for females and a sweatshirt/pullover for males) is a conceptual example of the proposed self-care textile wearable. Silver-coated conductive yarns were fabricated into hollow fiber-based non-woven fabrics for thermal stimulation. Significant drug delivery through the non-wovens was shown by the anti-breast cancer analysis. Drugs in different phases, liquid and crystal solid, could be carried by the lumens of the hollow fibers. If the proposed study is successfully commercialized, it will be a great technological breakthrough in preparing a future generation of drug delivery medical textiles. A variety of medical applications can hence be provided and it could also be an alternative for topical healthcare.
“…The exported drug delivery layers were then air-dried (Figure 2). 7–8 Figure 2.Schematic representation of the drug loading method by vacuum.…”
Section: Experimentation and Developmentmentioning
confidence: 99%
“…Hollow fibers, already known as promising fibers in medical and healthcare applications, have been studied for their drug loading and releasing abilities. [1][2][3][4][5][6][7][8] We reported on a new conceptual idea of designing transdermal self-care textile-based wearable system with thermally stimulated drug delivery function using hollow fibers in our previous studies. [7][8] Thermal stimulation involves the supply of heat energy by utilizing heat-releasing objects with designated thermal conductivity.…”
mentioning
confidence: 99%
“…It is believed that efficient delivery of drugs to skin under optimum conditions could be achieved by a self-heating system in a controllable catalyzed manner with defined delivery strategies through a combination of hollow fibers and thermosensitive technology. [7][8] To further progress the development of wearable self-care textiles, both physical and biological studies of the release system with thermal stimulation were performed. For physical testing, liquid release upon thermal stimulation was investigated by heating dye-loaded specimens at a specific temperature and measuring the corresponding visible absorbance of the dyes released from the specimens.…”
Previous studies have examined and verified the drug loading and releasing functionality from the interior channels of hollow fibers. An integrated design for self-care textile wearables with a thermally stimulated drug delivery function was proposed. To progress the in-depth development of the proposed self-care wearables, physical and biological investigations, including i) liquid release with thermal stimulation and ii) drug release upon thermal stimulation, were conducted. Physical investigation revealed that the concentration of dyes released from the heated specimens increased with higher temperature during the initial first hour of delivery. Moreover, higher cytotoxic effect could be induced with drugs delivered through heated specimens under higher thermal stimulated energy through biological examination. These results set up milestones for demonstrating the influence of thermal energy on different therapeutic requirements, such as rapid-onset transdermal medication.
Drug-eluting medical textiles have recently gained great attention to be used in different applications due to their cost effectiveness and unique physical and chemical properties. Using various fiber production and textile fabrication technologies, fibrous constructs with the required properties for the target drug delivery systems can be designed and fabricated. This review summarizes the current advances in the fabrication of drug-eluting medical textiles. Different fiber production methods such as melt-, wet-, and electro-spinning, and textile fabrication techniques such as knitting and weaving are explained. Moreover, various loading processes of bioactive agents to obtain drug-loaded fibrous structures with required physicochemical and morphological properties, drug delivery mechanisms, and drug release kinetics are discussed. Finally, the current applications of drug-eluting fibrous systems in wound care, tissue engineering, and transdermal drug delivery are highlighted.
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