Functional differentiation within the medial temporal lobe in the rat

Jarrard, Leonard E.; Davidson, Terry L.; Bowring, Beverly

doi:10.1002/hipo.10194

Cited by 53 publications

(48 citation statements)

References 70 publications

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“…The evidence now suggests that this PR function can subserve both defensive conditioning (Fig. 6 B) (Bucci et al, 2000) and working memory (Young et al, 1997;Murray and Richmond, 2001;Jarrard et al, 2004).…”

Section: Neurophysiological Basis Of the Cs-dependent Pr Requirementmentioning

confidence: 85%

“…All surgical procedures were performed under aseptic conditions. Aspiration PR lesions were used because we found this permits more complete and selective damage than neurotoxin lesions (Jarrard et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

“…A double dissociation was reported in the rat, where pretraining lesions of the PR and the adjacent postrhinal cortex (POR), but not the EC, impaired nonspatial working memory, whereas damage to the EC, but not the PR and POR, produced deficits in spatial reference memory (Jarrard et al, 2004). Damage to the PR, but not the EC, was also reported to interfere with working memory in rhesus monkeys (Meunier et al, 1993).…”

Section: Mnemonic Effects Of Pr Lesion Size and Of Extra-pr Damagementioning

confidence: 95%

“…The ability to record and reproduce rat USVs inexpensively and with excellent fidelity now allows these questions to be explored in detail. Studies of both rodents (Young et al, 1997;Bucci et al, 2002;Jarrard et al, 2004) and primates (Suzuki, 1996;Gaffan and Buckley, 1998;Buffalo et al, 1999;Baxter and Murray, 2001) encourage the idea that the PR is importantly involved in processing and/or maintaining representations of complex stimulus configurations. Variations on the approach described here should be useful for exploring the unique or distinctive contributions of PR in fear conditioning to complex cues.…”

Section: Role Of Pr Circuits In Processing Complex Stimulimentioning

confidence: 99%

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Perirhinal Cortex Supports Delay Fear Conditioning to Rat Ultrasonic Social Signals

Lindquist¹,

Jarrard²,

Brown³

2004

J. Neurosci.

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Auditory information can reach the lateral nucleus of the amygdala (LA) through a monosynaptic thalamic projection or a polysynaptic cortical route. The polymodal input from the perirhinal cortex (PR) is a major informational gateway to the LA and nearby structures. Pretraining PR lesions impair fear conditioning to a context, but there have been no reports that they cause deficits in delay conditioning to an auditory cue. The direct subcortical projection to the LA seems sufficient to support delay conditioning to a tone conditional stimulus (CS). We examined the effect of PR lesions on delay conditioning to two different tone conditional stimuli (4 and 22 kHz tones; both 10 sec duration) and two different rat ultrasonic vocalization (USV) conditional stimuli (10 sec of "22 kHz USVs"). The two USV conditional stimuli were multi-call segments that were recorded (digitized at 100 kHz) from two different rats. One USV CS was a continuous sequence of eight calls, and the other was a portion of a continuous sequence of six calls. PR lesions significantly impaired conditioning to both USV conditional stimuli and to the training context but had no significant effect on conditioning to either tone CS. The role of PR in fear conditioning appears not to be determined by whether the conditional stimuli serve as contexts or cues, but instead by the nature or complexity of the stimuli or stimulus configurations. These cue-specific effects of PR lesions are suggested to reflect differences in the stimulus features that are encoded in the two CS pathways to the LA.

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Section: Neurophysiological Basis Of the Cs-dependent Pr Requirementmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Mnemonic Effects Of Pr Lesion Size and Of Extra-pr Damagementioning

confidence: 95%

Section: Role Of Pr Circuits In Processing Complex Stimulimentioning

confidence: 99%

See 2 more Smart Citations

Perirhinal Cortex Supports Delay Fear Conditioning to Rat Ultrasonic Social Signals

Lindquist¹,

Jarrard²,

Brown³

2004

J. Neurosci.

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“…Some studies report impairment on the water maze task (Kaut and Bunsey, 2001;Liu and Bilkey, 2001) and others do not (Bussey et al, 1999;Mumby and Glenn, 2000). A radial maze study suggested that impairment associated with perirhinal-postrhinal damage might depend more on the type of memory tested than on the spatial requirements of the task (Jarrard et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Corticohippocampal Contributions to Spatial and Contextual Learning

Burwell

Saddoris²,

Bucci³

et al. 2004

J. Neurosci.

210

154

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Spatial and contextual learning are considered to be dependent on the hippocampus, but the extent to which other structures in the medial temporal lobe memory system support these functions is not well understood. This study examined the effects of individual and combined lesions of the perirhinal, postrhinal, and entorhinal cortices on spatial and contextual learning. Combined lesions of perirhinal plus lateral entorhinal or postrhinal plus medial entorhinal cortices resulted in deficits in acquisition of contextual discrimination but had no effect on place learning in the water maze. Finally, a parahippocampal lesion comprising combined neurotoxic damage to perirhinal, postrhinal, and entorhinal cortices resulted in profound impairment in acquisition of a standard passive avoidance task but failed to impair place learning. In the same experiment, rats with hippocampal lesions were impaired in spatial navigation. These results indicate that tasks requiring the association between context and an aversive stimulus depend on corticohippocampal circuitry, whereas place learning in the water maze can be accomplished without the full complement of highly processed information from the cortical regions surrounding the hippocampus. The evidence that different brain systems underlie spatial navigation and contextual learning has implications for research on memory when parahippocampal regions are involved.

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Roles of learning and motivation in preference behavior: Mediation by entorhinal cortex, dorsal and ventral hippocampus

Stouffer

White

2006

Hippocampus

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In the latent cue preference (LCP) task, water-deprived rats alternately drink a salt solution in one distinctive compartment of a conditioned cue preference (CCP) apparatus and water in the other compartment over 8 days (training trials). They are then given a choice between the two compartments with no solutions present (preference test). Previous findings showed that this training procedure results in two parallel forms of learning: conditioning to water-paired cues (a water-CCP) and latent learning of an association between salt and salt-paired compartment cues (a salt-LCP). Experiment 1 examined these two types of learning in isolation. Results showed that expression of the salt-LCP required salt deprivation during testing, but expression of the water-CCP did not require a deprivation state during testing. Other results showed that salt-LCP learning itself involves two distinct components: (1) the latent association among neutral cues in the salt-paired compartment, and (2) motivational information about salt deprivation during testing. Previous findings also demonstrated roles for the dorsal hippocampus (DH), ventral hippocampus (VH), and entorhinal cortex (EC) in salt-LCP learning. Experiment 2 examined the involvement of these structures during acquisition or expression of salt-LCP learning. Rats with cannulas aimed at DH, VH, or EC were given infusions of muscimol, either before exposure to the salt-paired, but not the water-paired, compartment during training or before the preference test. Inactivation of the DH or EC impaired both acquisition and expression of the association between salt and salt-paired compartment cues, while inactivation of the VH disrupted the influence of motivational information about salt deprivation required to express the salt-LCP. These results suggest unique roles for the EC-DH circuit and VH in salt-LCP learning, as well as a functional dissociation between the DH and VH.

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Functional differentiation within the medial temporal lobe in the rat

Cited by 53 publications

References 70 publications

Perirhinal Cortex Supports Delay Fear Conditioning to Rat Ultrasonic Social Signals

Perirhinal Cortex Supports Delay Fear Conditioning to Rat Ultrasonic Social Signals

Corticohippocampal Contributions to Spatial and Contextual Learning

Roles of learning and motivation in preference behavior: Mediation by entorhinal cortex, dorsal and ventral hippocampus

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