Functional duality of ethanol on cancer

An, Shanshan; Li, Xiaoxia; Tang, Man Wai; Yan, Sirui; Yang, Fan; Zhu, Xiang Yang; Chen, Ziting; Liu, Qiuyun

doi:10.1016/j.mehy.2018.11.007

Cited by 9 publications

(17 citation statements)

References 12 publications

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“…2 Because ethanol and acetic acid are structurally similar to oxalate, red wines reduce the risk of heart disease and dementia and can extend one's lifespan, possibly via the inhibition of oxalate generation (Figure 1). 4 In older people who have attenuated respiratory chain activities, the Krebs cycle and its shunt produce excess protons and organic acids such as oxalate ( Figure 1). Alzheimer's disease and cancer are mutually protective.…”

Section: Introductionmentioning

confidence: 99%

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy

Zhang

Shi

et al. 2020

J Int Med Res

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Numerous risk factors for heart disease or dementia harbor over 10% valine plus glycine content. Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences. The two γ-methyl groups in valine enable hyperconjugation, which enhances the van der Waals interaction between its side group and the carbonyl carbon. This extends the C=O bond length, and this weakened C=O bond augments the secondary chemical bonding of the carbonyl oxygen atom to cations. This, in turn, promotes the formation and buildup of insoluble and rigid salts such as calcium oxalate, which is postulated to be a major cause of heart disease. Similarly, the long C=O bond length in glycine results in a weakened C=O bond with an enhanced affinity toward cations and the formation of insoluble salts. Further, several prion proteins possess a high glycine content of approximately 20%. The insoluble calcium salts produced may promote aggregate formation via secondary chemical bonding between calcium and glycine, as well as between calcium and valine. Chemical and biochemical insights will help us to better understand the etiology of disorders linked to protein aggregates.

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Section: Introductionmentioning

confidence: 99%

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy

Zhang

Shi

et al. 2020

J Int Med Res

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“…2 The primary pathway and the shunt of the Krebs cycle churn out protons and oxalate, and cancer cells might overproduce organic acids such as oxalate to counteract strong acids. 4 Calcium oxalate causes cell senescence and perhaps human death. 4 Ethanol and acetic acids are structurally similar to oxalate and are beneficial to heart disease and extend lifespan, 4 perhaps by the competitive inhibition of oxalate production.…”

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confidence: 99%

Cellular States and Secondary Chemical Bonding: A Biochemical View of Major Human Diseases

Wan

Zhang

et al. 2019

Biochem Insights

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Nasopharyngeal carcinoma is prevalent in hot and humid areas such as south coastal China and Southeast Asia, but not in the non-coastal southern Chinese Yunnan Province. Secondary chemical bonding may underlie such phenomena. Cancer may be caused by strong acids such as HCl, whereas insoluble and rigid salts such as calcium oxalate are the potential causative factors of heart disease and the Alzheimer disease. The weak organic acids produced by plants counteract strong acids and dissolve insoluble salts, therefore boasting dual roles in disease prevention and treatments. The aforementioned perspective sheds light on the underlying mechanism of human disorders and opens new avenues in the interventions of numerous diseases.

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“…A hypothesis was previously postulated that cancer onset is triggered by the local buildup of hydrogen chloride, comediated by hydrogen bond donors and acceptors, and basic amino acids. 17 - 19 Red meat is presumed to be slightly carcinogenic as defined by World Health Organization and marked by the presence of myoglobin which harbors around 20% to 21% positively charged basic amino acids, attracting anions such as Cl − and contributing to the local formation of hydrogen chloride. 17 , 18 Boiled red meat with denatured proteins retain its carcinogenic potential.…”

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confidence: 99%

“…Triacylglycerides, glucose, and ethanol harbor oxygen atoms or hydroxyl groups capable of hydrogen bonding and give rise to higher cancer risks in individuals with obesity, diabetes, and alcoholism, respectively. 19 - 21 Calcium supplement capable of neutralizing strong acids significantly reduces cancer incidences. 5 The noncoastal southern Yunnan Province and nonhumid central provinces in China has low nasopharyngeal cancer prevalence, whereas the humid coastal southern provinces in China and Southeast Asia have high nasopharyngeal cancer rates, 22 suggesting that hydrogen bonding to protons plays a critical role in carcinogenesis of the nasopharyngeal cavity in high-humidity regions.…”

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confidence: 99%

“… 23 Enhanced hydrogen bonding to protons is likely to be the culprit. 17 - 19 It was proposed that the strength of local acidity is vital for cancer growth and metastasis, since weak acid lowers cancer incidences. 24 - 26 Chinese vinegar factories reported few cancer cases over decades, 24 - 26 and the vicinity of these factories also had low cancer incidences, 24 suggesting that the volatile and weak acetic acid may counteract strong acids.…”

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confidence: 99%

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Is Weak Acid Beneficial for Addressing Checkpoint Inhibitor–Triggered Cancer Hyper Progression in Anti-PD1/PD-L1 Immunotherapies?

Wan

Zhou

et al. 2020

Cancer Control

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Numerous cases of checkpoint inhibitor–triggered cancer hyperprogression have been documented. A previous hypothesis attributes cancer onset to the local buildup of hydrogen chloride, jointly mediated by hydrogen bond donors and acceptors and basic amino acids. The anti-PD1/PD-L1 immunotherapies may have caused a surge of protons or chloride ions for the effective treatment of neoplasm, thus giving rise to the local formation of hydrogen chloride and subsequently cancer hyperprogression in some susceptible individuals. It was postulated that the local strength of acidity is critical for tumor growth and metastasis, as the intake of weak organic acids reduces cancer risks. The anti-PD1/PD-L1 immunotherapies can be integrated with weak organic acids to reduce adverse reactions and generate better anticancer outcomes.

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Functional duality of ethanol on cancer

Cited by 9 publications

References 12 publications

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy

Cellular States and Secondary Chemical Bonding: A Biochemical View of Major Human Diseases

Is Weak Acid Beneficial for Addressing Checkpoint Inhibitor–Triggered Cancer Hyper Progression in Anti-PD1/PD-L1 Immunotherapies?

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