Functional dyspepsia

Talley, Nicholas J.; Goodsall, Thomas M; Potter, Michael

doi:10.18773/austprescr.2017.066

Cited by 45 publications

(68 citation statements)

References 32 publications

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“…Because delayed gastric emptying is considered a pathophysiological mechanism of functional dyspepsia 172,173 , some experts advocate the assessment of this parameter in the diagnostic work-up. However, the correlation between gastric emptying and dyspeptic symptoms is still unclear, and treatment of delayed of gastric emptying with prokinetic drugs poorly correlates with symptomatic improvement 174 .…”

Section: Laboratory Testsmentioning

confidence: 99%

Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

260

247

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| Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation. A genetic predisposition is probable but less evident than in other functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). Psychiatric comorbidity and psychopathological state and trait characteristics could also play a part, although they are not specific to functional dyspepsia and are less pronounced than in IBS. Possible differential diagnoses include Helicobacter pylori infection and peptic ulceration. Pharmacological therapy is mostly based on the subtype of functional dyspepsia, such as prokinetic and fundus-relaxing drugs for PDS and acid-suppressive drugs for EPS, whereas centrally active neuromodulators and herbal drugs play a minor part. Psychotherapy is effective only in a small subset of patients, whereas quality of life can be severely affected in nearly all patients. Future therapies might include novel compounds that attempt to treat the underlying gastric and duodenal inflammation. NATURE REVIEWS | DISEASE PRIMERS VOLUME 3 | ARTICLE NUMBER 17081 | 1 PRIMER © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .standard therapy for gastro -oesophageal reflux disease. Paediatric dyspeptic symptoms are being addressed in a separate classification effort 10 . This Primer covers functional dyspepsia in adults only, although we sporadically refer to paediatric functional dyspepsia when similarities exist. EpidemiologyThe population prevalence of functional dyspepsia is quite variable across the globe, with overall high numbers (10-40%) in Western countries and low numbers (5-30%) in Asia, independent of the respective functional dyspepsia definitions 11 . A large-scale health and nutrition survey from France 12 (which involved >35,000 people) identified that 15% of individuals had suspected functional dyspepsia, 28% had irritable bowel syndrome (IBS) and 6% had both. The population of patients who are affected by both IBS and functional dyspepsia has been reported to range between 10% and 27% in previous studies 13 and to approach 30% in popu lation samples; it could be even higher in specific populations 14,15 . This observation has given rise to the term 'overlap syndrome' (REF. 13), which calls into question the sensitivity and specificity of the Rome criteria, at least for IBS and functional dyspepsia. This argument is also supported by the observation that patients with functional dyspepsia m...

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Section: Laboratory Testsmentioning

confidence: 99%

Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

260

247

View full text Add to dashboard Cite

show abstract

“…These symptoms may result from different diseases such as peptic ulcer, gastric cancer and, most importantly, functional dyspepsia (FD) (13,17,39,46) . These dyspeptic symptoms may also be related to intestinal parasitosis, such as Giardiasis and strongyloidiasis, and in Brazil this may be important for a differential diagnosis (34) .…”

Section: Introductionmentioning

confidence: 99%

“…It affects 25% to 40% of the adults in Western populations (higher prevalence are described in studies that also included heartburn, which is considered a cha ra c teristic symptom of the gastroesophageal reflux disease) (15,18,27) . Dyspeptic complaints are responsible for 2% to 5% of outpatient visits in general practitioners, in a primary care center, and 20% to 40% of gastroenterology appointments, and represent a great impact on the quality of life of patients (1,19,31,46) . Dyspepsia is clas sified as an organic disease (when is secondary to specific lesions, such as esophagitis, peptic ulcer or gastric cancer) (22) or FD (in the absence of structural abnormalities or metabolic and biochemical irregularities that justify the symptoms) (16 18) .…”

Section: Introductionmentioning

confidence: 99%

“…The Rome consensus suggests the use of specific questionnaires for FD diagnosis, with a validated version for the local language (40) , which can be used in the diagnostic investiga tion, by the assistant doctor, or for basic research purposes, but it stresses that physical examination and complementary exams are fundamental to confirm a diagnosis (16,46) .…”

Section: Introductionmentioning

confidence: 99%

“…Dyspeptic symptoms may appear at any age and are more frequent among women, probably due to the fact that the female population seeks medical help quicker (2,46,49) . The intensity of pain and/or discomfort, and anxiety (including the fear of more serious diseases), are the main reasons for seeking a clinical or gastroenterologist opinion.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of dyspeptic symptoms and heartburn of adults in Belo Horizonte, Brazil

Almeida

Martins

Cunha

et al. 2017

Arq. Gastroenterol.

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-Background -Medical literature has shown dyspepsia and heartburn related symptoms occur among 15% to 40% of the population. These symptoms can occur at any age and are more prevalent in women. Objective -Investigate the prevalence of dyspeptic symptoms and heartburn among individuals over 18. Methods -Individuals over 18 were randomly selected in public venues in Belo Horizonte/MG to participate. A standardized questionnaire that included questions related to social demographic characteristics, eating habits, digestive symptoms, medical appointments, medi cations, exams, previous surgeries and comorbidities was applied. A questionnaire about functional dyspepsia diagnosis (Rome III) was also applied.Results -A total of 548 individuals were interviewed. Among these, 58.4% were women, 59.3% were white, 55.9% were single and the average age was 36 years. Within this group, 376 individuals (68.6%) declared to have some symptom and/or use medication to relieve dyspepsia symptoms, and for these patients were applied the Rome III questionnaire. Based on the diagnostic criteria for the questionnaire proposed by the Rome III consensus, the symptom of postprandial fullness was reported by 6.7% of the individuals, early satiety (3.5%) and epigastric pain (10.6%). The overlap of these symptoms was very frequent. The prevalence of functional dyspepsia was 10.6% (postprandial discomfort syndrome (8.2%) and epigastric pain syndrome (2.4%). Among all participants, 52.5% reported heartburn, and 11.1% presented this symptom at least once a week. The most used drug was omeprazole. Conclusion -The prevalence of dyspeptic symptoms and heartburn among a Brazilian adult urban population is similar to those described in other countries. HEADINGS -Dyspepsia, diagnosis. Heartburn. Consenso.

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Mechanically Asymmetrical Triboelectric Nanogenerator for Self‐Powered Monitoring of In Vivo Microscale Weak Movement

Cheng

et al. 2020

Advanced Energy Materials

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Although much effort has been put in the studies of weak in vivo microscale movements due to its importance, the real‐time, long‐time, and accurate monitoring is still a great challenge because of the complexity of the in vivo environment. Here, a new type of mechanically asymmetrical triboelectric nanogenerator with ultrashort working distance and high anti‐interference ability is developed to accurately and real‐timely monitor the microscopically weak movement of intestinal motility at low frequencies even around 0.3 Hz. The intestinal status after the glucose absorption, and physiological states in different times also have been monitored successfully in the complex in vivo environment with many kinds of interference and noises. This work gives a new self‐powered, long‐time and in vivo technical way for the real‐timely gastrointestinal motility monitoring, and contributes to the detection of every kind of gentle movements in various complex bio‐systems.

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Functional dyspepsia

Cited by 45 publications

References 32 publications

Functional dyspepsia

Functional dyspepsia

Prevalence of dyspeptic symptoms and heartburn of adults in Belo Horizonte, Brazil

Mechanically Asymmetrical Triboelectric Nanogenerator for Self‐Powered Monitoring of In Vivo Microscale Weak Movement

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