Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells

Baez-Gonzalez, Andrea S.; Carrazco-Carrillo, Jaime A.; Figueroa-Gonzalez, Gabriela; Quintas-Granados, Laura Itzel; Padilla-Benavides, Teresita; Reyes-Hernandez, Octavio D.

doi:10.1016/j.bbrep.2023.101492

Cited by 6 publications

(2 citation statements)

References 64 publications

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“…According to a recent study, it was found that administering I3C at a concentration of 10 µM for 48 h effectively hampered cell growth in human breast cancer cells (MCF-7, MDA-MB-231) by triggering the apoptotic pathway (Caspase 3-4-8) [ 168 ]. The activation of the apoptotic pathway was attributed to the suppression of the Akt and NF-kB signaling pathways by I3C [ 169 , 170 ].…”

Section: Glucosinolatesmentioning

confidence: 99%

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

Mecca,

Sichetti,

Giuseffi

et al. 2024

Nutrients

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Breast cancer is the most common tumor in women. Chemotherapy is the gold standard for cancer treatment; however, severe side effects and tumor resistance are the major obstacles to chemotherapy success. Numerous dietary components and phytochemicals have been found to inhibit the molecular and signaling pathways associated with different stages of breast cancer development. In particular, this review is focused on the antitumor effects of PUFAs, dietary enzymes, and glucosinolates against breast cancer. The major databases were consulted to search in vitro and preclinical studies; only those with solid scientific evidence and reporting protective effects on breast cancer treatment were included. A consistent number of studies highlighted that dietary components and phytochemicals can have remarkable therapeutic effects as single agents or in combination with other anticancer agents, administered at different concentrations and via different routes of administration. These provide a natural strategy for chemoprevention, reduce the risk of breast cancer recurrence, impair cell proliferation and viability, and induce apoptosis. Some of these bioactive compounds of dietary origin, however, show poor solubility and low bioavailability; hence, encapsulation in nanoformulations are promising tools able to increase clinical efficiency.

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Section: Glucosinolatesmentioning

confidence: 99%

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

Mecca,

Sichetti,

Giuseffi

et al. 2024

Nutrients

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show abstract

“…In addition, I3C at 10 µM decrease proliferation in several cancer cell lines, such as cervical cancer cell lines (HeLa, MCF7, and MDA-MB-231) and adenocarcinoma cells (HCT-8). However, the hepatocellular carcinoma cell line (HepG2) showed sensitivity to 5 µM of I3C [ 90 ]. Then, these results suggested that DIM and I3C has different mechanism of action depending at least on the type of cancer, the genotype of the cancer cell line and that several factors needed to be addressed to determine whether I3C and DIM have a different effect depending on the type of cancer.…”

Section: Introductionmentioning

confidence: 99%

3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

Reyes-Hernández,

Figueroa-González,

Quintas-Granados

et al. 2023

Cancer Cell Int

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Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabbage, and brussels sprouts. They are synthesized after glycolysis from the glucosinolate structure. Clinical and preclinical trials have evaluated the pharmacokinetic/pharmacodynamic, effectiveness, antioxidant, cancer-preventing (cervical dysplasia, prostate cancer, breast cancer), and anti-tumor activities of I3C and DIM involved with polyphenolic derivatives created in the digestion showing promising results. However, the exact mechanism by which they exert anti-cancer and apoptosis-inducing properties has yet to be entirely understood. Via this study, we update the existing knowledge of the state of anti-cancer investigation concerning I3C and DIM chemicals. We have also summarized; (i) the recent advancements in the use of I3C/DIM as therapeutic molecules since they represent potentially appealing anti-cancer agents, (ii) the available literature on the I3C and DIM characterization, and the challenges related to pharmacologic properties such as low solubility, and poor bioavailability, (iii) the synthesis and semi-synthetic derivatives, (iv) the mechanism of anti-tumor action in vitro/in vivo, (v) the action in cellular signaling pathways related to the regulation of apoptosis and anoikis as well as the cell cycle progression and cell proliferation such as peroxisome proliferator-activated receptor and PPARγ agonists; SR13668, Akt inhibitor, cyclins regulation, ER-dependent-independent pathways, and their current medical applications, to recognize research opportunities to potentially use these compounds instead chemotherapeutic synthetic drugs.

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Cruciferous Plant Extracts, Their Isothyocianate or Indol Derivatives, and Their Effect on Cellular Viability of Breast Cancer Cell Lines

Sanchez-Guzman,

Alvarez-Domínguez,

Ramírez-Torres

et al. 2024

Journal of Medicinal Food

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Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells

Cited by 6 publications

References 64 publications

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

Cruciferous Plant Extracts, Their Isothyocianate or Indol Derivatives, and Their Effect on Cellular Viability of Breast Cancer Cell Lines

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