Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats

Beaumont, Éric; Guevara, Edgar; Dubeau, Simon; Lesage, Frédéric; Nagai, Mary K.; Popović, Miloš R.

doi:10.1179/2045772313y.0000000117

Cited by 32 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to previous studies, electrical stimulation can promote remyelination and improve the recovery of neurological function after SCI (Li et al, 2010;Beaumont et al, 2014). Furthermore, the direction of the electrode can affect nerve regeneration.…”

Section: Discussionmentioning

confidence: 92%

“…In previous studies, electrical stimulation has been shown to enhance remyelination and to lead to the recovery of motor function in CNS injury (Becker et al, 2010;Li et al, 2010). As an exogenous factor, electrical stimulation was considered a promising method for the treatment of SCI (Becker et al, 2010;Beaumont et al, 2014). However, some limitations in the effects of electrical stimulation on nerve regeneration have been proposed by different authors (McCaig, 1987;Fehlings et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improved differentiation of oligodendrocyte precursor cells and neurological function after spinal cord injury in rats by oscillating field stimulation

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Improved differentiation of oligodendrocyte precursor cells and neurological function after spinal cord injury in rats by oscillating field stimulation

et al. 2015

View full text Add to dashboard Cite

“…To our knowledge, our study is the first to bring insight on sensorimotor integration in the trunk motor cortex. This is of fundamental importance since many studies have demonstrated that sensory feedback to the motor cortex is critical during locomotion and recovery of function after spinal cord injury (2,35,53,(62)(63)(64) Indeed, low amplitude tactile stimulation of dorsal trunk did not impact trunk M1. On the other hand, high amplitude stimulation of both the forelimbs and hindlimbs, conveying proprioceptive information, did reach trunk M1.…”

Section: Integration Of Sensorimotor Information Within Trunk M1 Is Nmentioning

confidence: 99%

Trunk sensory and motor cortex is preferentially integrated with hindlimb sensory information that supports trunk stabilization

Nandakumar

Blumenthal

Pauzin

et al. 2020

Preprint

View full text Add to dashboard Cite

Sensorimotor integration in the trunk system has been poorly studied despite its importance for examining functional recovery after neurological injury or disease. Here, we mapped the relationship between thoracic dorsal root ganglia and trunk sensory cortex (S1) to create a detailed map of the extent and internal organization of trunk primary sensory cortex, and trunk primary motor cortex (M1) and showed that both cortices are somatotopically complex structures that are larger than previously described. Surprisingly, projections from trunk S1 to trunk M1 were not anatomically organized. We found relatively weak sensorimotor integration between trunk M1 and S1 and between trunk M1 and forelimb S1 compared to extensive integration between trunk M1 and hindlimb S1 and M1. This strong trunk/hindlimb connection was identified for high intensity stimuli that activated proprioceptive pathways. To assess the implication of this integration, the responses in sensorimotor cortex were examined during a postural control task and supported sensorimotor integration between hindlimb sensory and lower trunk motor cortex. Together, these data suggest that trunk M1 is guided predominately by hindlimb proprioceptive information that reached the cortex directly via the thalamus. This unique sensorimotor integration suggests an essential role for the trunk system in postural control, and its consideration could be important for understanding studies regarding recovery of function after spinal cord injury.SignificanceThis work identifies extensive sensorimotor integration between trunk and hindlimb cortices, demonstrating that sensorimotor integration is an operational mode of the trunk cortex in intact animals. The functional role of this integration was demonstrated for postural control when the animal was subjected to lateral tilts. Furthermore, these results provide insight into cortical reorganization after spinal cord injury making clear that sensorimotor integration after SCI is an attempt to restore sensorimotor integration that existed in the intact system. These results could be used to tailor rehabilitative strategies to optimize sensorimotor integration for functional recovery.

show abstract

“…Additionally, electrical fields or direct electrical stimulation can influence nerves at the molecular level, influencing proliferation, migration, axonal regeneration, and function of nerve cells . Migration, axonal regeneration, and function are of the greatest interest from a tissue‐engineering perspective, where axons and glial cells need to be encouraged to regrow along or repopulate damaged peripheral or spinal nerve gaps.…”

Section: Bionicsmentioning

confidence: 99%

“…Migration, axonal regeneration, and function are of the greatest interest from a tissue‐engineering perspective, where axons and glial cells need to be encouraged to regrow along or repopulate damaged peripheral or spinal nerve gaps. Electrical fields and electrical stimulation have been used to enhance or direct axonal growth in vitro and in vivo and to control the migration of neuronal, astrocyte, and Schwann cells …”

Section: Bionicsmentioning

confidence: 99%

Graphite Oxide to Graphene. Biomaterials to Bionics

2015

View full text Add to dashboard Cite

The advent of implantable biomaterials has revolutionized medical treatment, allowing the development of the fields of tissue engineering and medical bionic devices (e.g., cochlea implants to restore hearing, vagus nerve stimulators to control Parkinson's disease, and cardiac pace makers). Similarly, future materials developments are likely to continue to drive development in treatment of disease and disability, or even enhancing human potential. The material requirements for implantable devices are stringent. In all cases they must be nontoxic and provide appropriate mechanical integrity for the application at hand. In the case of scaffolds for tissue regeneration, biodegradability in an appropriate time frame may be required, and for medical bionics electronic conductivity is essential. The emergence of graphene and graphene-family composites has resulted in materials and structures highly relevant to the expansion of the biomaterials inventory available for implantable medical devices. The rich chemistries available are able to ensure properties uncovered in the nanodomain are conveyed into the world of macroscopic devices. Here, the inherent properties of graphene, along with how graphene or structures containing it interface with living cells and the effect of electrical stimulation on nerves and cells, are reviewed.

show abstract

Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats

Abstract: Hind limb rehabilitation with FES is an effective strategy to improve locomotion during the acute phase post-SCI. The results of this study indicate that after FES, the CNS preserves/acquires the capacity to respond to peripheral electrical stimulation.

Cited by 32 publications

References 33 publications

Improved differentiation of oligodendrocyte precursor cells and neurological function after spinal cord injury in rats by oscillating field stimulation

Improved differentiation of oligodendrocyte precursor cells and neurological function after spinal cord injury in rats by oscillating field stimulation

Trunk sensory and motor cortex is preferentially integrated with hindlimb sensory information that supports trunk stabilization

Graphite Oxide to Graphene. Biomaterials to Bionics

Contact Info

Product

Resources

About