Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

Zheng, Qianlan; Xi, Yuewei; Weng, Yunxuan

doi:10.1039/d3ra07075a

Cited by 25 publications

(7 citation statements)

References 216 publications

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“…It must be noted that coaxial electrospraying is the key technique in the proposed combination. In this study, a detachable spinneret was developed for the coaxial electrospraying process, which has also been used in other EHDA processes, such as single-fluid electrospinning and coaxial electrospinning ( Chen et al, 2023b ; Zheng et al, 2024 ). The Teflon-coated concentric spinneret consists of a common metal-based concentric spinneret and a set of Teflon tubings ( Figure 2a1 ).…”

Section: Resultsmentioning

confidence: 99%

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Mao,

Zhou,

Yan

et al. 2024

Front. Bioeng. Biotechnol.

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Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency for patients. The combination of traditional pharmaceutical techniques and advanced material conversion methods can provide new solutions to this issue. In this research, a new kind of hybrid film was created via coaxial electrospraying, followed by a casting process. The films were composed of Reglan and 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in a polyvinylpyrrolidone (PVP) film matrix. Microscopic observations of these films demonstrated a solid cross section loaded with core-shell particles. X-ray diffraction and Fourier-transform infrared tests verified that the Reglan and 5-FU loaded in the films showed amorphous states and fine compatibilities with the polymeric matrices, i.e., PVP and CA, respectively. In vitro dissolution tests indicated that the films were able to provide the desired asynchronous dual-drug delivery, fast release of Reglan, and sustained release of 5-FU. The controlled release mechanisms were shown to be an erosion mechanism for Reglan and a typical Fickian diffusion mechanism for 5-FU. The protocols reported herein pioneer a new approach for fabricating biomaterials loaded with multiple drugs, each with its own controlled release behavior, for synergistic cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Mao,

Zhou,

Yan

et al. 2024

Front. Bioeng. Biotechnol.

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“…They are also implemented as sensors for detecting biomarkers or other substances in the body, where their high surface area and ability to function on a microscale make them ideal for detecting even the smallest amounts of substances. The use of nanofibers in biomedical engineering opens up new therapeutic and diagnostic possibilities, which can contribute to improving the health and quality of life of patients [133][134][135][136][137][138].…”

Section: Pes Nanofibersmentioning

confidence: 99%

“…The process involves using high electrical voltage to draw polymer fluid through a needle, thereby creating thin fibers. This method is relatively simple and allows for control over the size and shape of nanofibers [133,[136][137][138].…”

Section: Pes Nanofibersmentioning

confidence: 99%

Polyethersulfone Polymer for Biomedical Applications and Biotechnology

Wasyłeczko,

Wojciechowski,

Chwojnowski

2024

IJMS

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Polymers stand out as promising materials extensively employed in biomedicine and biotechnology. Their versatile applications owe much to the field of tissue engineering, which seamlessly integrates materials engineering with medical science. In medicine, biomaterials serve as prototypes for organ development and as implants or scaffolds to facilitate body regeneration. With the growing demand for innovative solutions, synthetic and hybrid polymer materials, such as polyethersulfone, are gaining traction. This article offers a concise characterization of polyethersulfone followed by an exploration of its diverse applications in medical and biotechnological realms. It concludes by summarizing the significant roles of polyethersulfone in advancing both medicine and biotechnology, as outlined in the accompanying table.

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“…This breakthrough enabled the creation of novel drug-loaded sheath nanofibers, which exhibited delayed quick release, prolonged slow-release, reduced tail break release, and the complete release of drug molecules. Non-spinnable liquids encompass pure solvents, surfactants, or salt solutions, significantly broadening the application scope of electrospun nanofibers [ 46 , 47 ].…”

Section: Preparation Of Drug-loaded Nanofibers Via Electrospinningmentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

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Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

Abstract: Electrostatic spinning as a technique for producing nanoscale fibers has recently attracted increasing attention due to its simplicity, versatility, and loadability.

Cited by 25 publications

References 216 publications

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Polyethersulfone Polymer for Biomedical Applications and Biotechnology

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

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