2013
DOI: 10.1002/lt.23592
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Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy

Abstract: We quantified rates of hepatic regeneration and functional recovery for 6 months after right hepatic lobectomy in living donors for liver transplantation. Twelve donors were studied at baseline; eight retested at (mean±SD) 11±3 days (T1), 10 at 91±9 days (T2), and 10 at 185±17 days (T3) after donation. Liver and spleen volumes were measured by computed tomography (CT) and single photon emission computed tomography (SPECT). Hepatic metabolism was assessed from caffeine and erythromycin, and hepatic blood flow f… Show more

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Cited by 33 publications
(25 citation statements)
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“…Table 4 summarizes the results of important published studies on liver functional and volumetric recovery in right lobe living donors. Regarding the rate of liver function recovery in donors, while some studies show that complete normalization of liver function tests occurs within the first postoperative week (nine studies) (12)(13)(14)(15)(16)(17)(18) or within the first month (13 studies) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), others show that this takes anywhere between 3 months and 1 year after donor hepatectomy (31)(32)(33)(34)(35)(51)(52)(53)(54). This variance can be attributed in part to the absence of a universal definition for ''liver functional recovery.''…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Table 4 summarizes the results of important published studies on liver functional and volumetric recovery in right lobe living donors. Regarding the rate of liver function recovery in donors, while some studies show that complete normalization of liver function tests occurs within the first postoperative week (nine studies) (12)(13)(14)(15)(16)(17)(18) or within the first month (13 studies) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), others show that this takes anywhere between 3 months and 1 year after donor hepatectomy (31)(32)(33)(34)(35)(51)(52)(53)(54). This variance can be attributed in part to the absence of a universal definition for ''liver functional recovery.''…”
Section: Discussionmentioning
confidence: 99%
“…Contrary to findings in other studies (20,32,37) [14,18]), and also during the first month, (RLL/TLV ranged from 64% to 89% [25,30,33,49], and mean liver growth from 115% to 181% [14,25,27]). After the initial month, the rate of regeneration slowed down, RLL/TLV reaching 74-80% (33,38,40,53), 72-96% (17,23,29,31,37,46,(51)(52), and 80-97% (16,23,26,29,31,33,40,53) in the first 3 months, 6 months, and 1 year, respectively, after donor right hepatectomy. In our study, liver volume increased to more than 2Â estimated remnant liver volume at the end of 1 year, yet ad integrum liver regeneration did not occur.…”
Section: Discussionmentioning
confidence: 99%
“…This is the first study to describe serial changes in plasma biomarker levels after partial hepatectomy in a uniform population. It is well known that liver regeneration is rapid in the first 2 weeks after liver resection, but it continues for many weeks after partial hepatectomy; plus, the factors involved in termination of liver regeneration are not well known. Another key point of this study is that the biomarkers were analyzed until the end of 6 weeks after hepatectomy in order to study the markers involved in the termination of liver regeneration process.…”
Section: Discussionmentioning
confidence: 99%
“…The dual cholate test quantifies the simultaneous processes of hepatocyte uptake, clearance from the systemic circulation, clearance from the portal circulation, and portal‐systemic shunting . The test has proven useful for defining liver disease severity, monitoring the natural course of disease progression, quantifying the response to antiviral therapy and assessing liver regeneration after living liver donation . Since two different labelled forms of cholate are administered simultaneously (per oris and intravenously), this test has the unique ability among liver functional tests to dissect the relative contribution of hepatocellular insufficiency from porto‐systemic shunting.…”
Section: The Use Of Metabolic Tests In Assessing the Severity Of Livementioning
confidence: 99%