Functional Endoluminal Paving (FELP): Thermoforming, Biodegradation, and Mechanical Properties of a Novel Polymer Graft for Abdominal Aortic Aneurysms

Ashton, John H.; Mertz, James A. M.; Alexander, Megan J.; Slepian, Marvin J.; Mills, Joseph L.; Geest, Jonathan P. Vande

doi:10.1115/sbc2010-19463

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“…The degree of significance is indicated as ***P ≤ 0.001, **P ≤ 0.01 and *P ≤ 0.05. studies, however. Lipase has also been shown to degrade various polyester biomaterials in other studies [16,36,44,45]. In examining thermally cured PGS, lipase treatment produced a reduction in mass of ∼12% after 8 days and ∼30% after 31 days, in vitro [44].…”

Section: Resultsmentioning

confidence: 91%

Synthesis, Characterization and 3D Micro-Structuring via 2-Photon Polymerization of Poly(glycerol sebacate)-Methacrylate–An Elastomeric Degradable Polymer

et al. 2018

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Poly(glycerol sebacate) (PGS) has been utilized in numerous biomaterial applications over recent years. This elastomeric and rapidly degradable polymer is cytocompatible and suited to various applications in soft tissue engineering and drug delivery. Although PGS is simple to synthesize as an insoluble prepolymer, it requires the application of high temperatures for extended periods of time to produce an insoluble matrix. This places limitations on the processing capabilities of PGS and its possible applications. Here, we present a photocurable form of PGS with improved processing capabilities: PGS-methacrylate (PGS-M). By methacrylating the secondary hydroxyl groups of the glycerol units in the PGS prepolymer chains, the material was rendered photocurable and, in combination with a photoinitiator, crosslinked rapidly on exposure to UV light at ambient temperatures. The polymer's molecular weight and the degree of methacrylation could be controlled independently and the mechanical properties of the crosslinked material tailored. The polymer also displayed rapid degradation under physiological conditions and cytocompatibility with various primary cell types. As a demonstration of the processing capabilities of PGS-M, µm scale 3D scaffold structures were fabricated using 2-photon polymerization and used for 3D cell culture. The tunable properties of PGS-M coupled with its enhanced processing capabilities make the polymer an attractive potential biomaterial for various future applications.

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