Functional evaluation of parathyroid adenoma using 99mTc-MIBI parathyroid SPECT/CT

Abstract

Quantitative indices of parathyroid SPECT/CT closely correlate with laboratory functional markers and disease severity of parathyroid adenoma. Thus, parathyroid SPECT/CT could be used for evaluation of the underlying functional state and disease severity of parathyroid adenoma, particularly for decision pertaining to surgical treatment.

Detection rate of 99mTc‐MIBI single photon emission computed tomography (SPECT)/CT in preoperative planning for patients with primary hyperparathyroidism: A meta‐analysis

“…Reviewing titles and abstracts, 546 articles were excluded: 489 because they were not in the field of interest of this review, 22 were reviews, editorials, or letters, and 35 were case reports or small case series. Thus, 26 full‐text articles were assessed for eligibility . No additional studies were found after screening the references of these articles.…”

“…Three articles were excluded from the meta‐analysis for possible data overlap with articles published by the same group . Finally, 23 articles, including 1236 patients with PHPT who underwent 99m Tc‐MIBI SPECT/CT before surgery, were selected and were eligible for the systematic review and meta‐analysis . Twenty and 19 , articles provided sufficient data for the detection rate calculation of 99m Tc‐MIBI SPECT/CT on a per patient‐based and a per lesion‐based analysis, respectively (Figure ).…”

“…Using the database search, 23 original articles written over the past 10 years were selected . Of the aforementioned articles, only 4 were prospective studies .…”

“…Twenty articles, including 943 patients, were used to calculate the pooled detection rate of 99m Tc‐MIBI SPECT/CT on a per patient‐based analysis . Nineteen articles, including 963 lesions, were used to calculate the pooled detection rate of 99m Tc‐MIBI SPECT/CT on a per lesion‐based analysis …”

Parathyroid adenoma localization with 99mTc-sestamibi SPECT/CT

“…In one study, combined parathyroid SPECT/CT with preoperative Im et al [31] Reference Sensitivity (95% Cl) Weight% In one study, combined parathyroid SPECT/CT with preoperative Im et al [31] Reference Sensitivity (95% Cl) Weight%…”