Functional exercise capacity evaluated by timed walk tests in myasthenia gravis

Salcı, Yeliz; Karanfil, Ecem; Balkan, Ayla Fil; Çalık-Kütükçü, Ebru; Ceren, Ali Naim; Ayvat, Fatma; Bekircan-Kurt, Can Ebru; Armutlu, Kadriye

doi:10.1002/mus.26345

Cited by 17 publications

(14 citation statements)

References 31 publications

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“…The 6-min walk test (6MWT) allowed determining the cardiorespiratory fitness of the participants (VO2max). This test can accurately estimate VO2max in a healthy adult population [35] with excellent test-retest reliability and moderate construct validity for the evaluation of patients with good functional capacity to perform exercises [36]. It can also be used to predict cardiorespiratory fitness in asymptomatic individuals [37] and it has been used in studies with patients who had different symptoms [38][39][40].…”

Section: Methodsmentioning

confidence: 99%

Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme

et al. 2020

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Ageing and diabetes are recognised as important risk factors for the development of cognitive deterioration. The aim was to analyse the effects of a walking-based training programme on cognitive deterioration and glycosylated haemoglobin (HbA1c) in older women with type 2 diabetes. This was a six-month experimental and longitudinal study with an experimental group (EG) (n = 57) and a control group (CG) (n = 52). All participants were diabetic with hypoglycaemic treatment. EG carried out a walking-based training program. After the training, we evaluated the diabetic state (HbA1c), cognitive functioning with the Mini-Mental State Examination (MMSE), cardiorespiratory fitness (VO2max) and body mass index (BMI). Results: EG obtained better results than CG in all the analysed variables. EG showed a significant improvement in the levels of HbA1c (−4.5%; p < 0.001), VO2max (+5.9%; p < 0.001) and BMI (−5.4%; p < 0.001); it also obtained increases in the scores of cognitive functioning, which were statistically significant in all dimensions, except for calculation (p = 0.384) and language (p = 0.168). Conclusion: The aerobic treatment produced significant improvements in the diabetic state and cognitive functioning in older women with type 2 diabetes.

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Section: Methodsmentioning

confidence: 99%

Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme

et al. 2020

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“…They performed similarly in their ability to reflect which MGFA severity class (II or III) the patients fitted into. The study also noted the difficulty in practically measuring maximum oxygen consumption in a clinical setting (25). Other potential confounding factors which may influence result analysis in these types of exercise studies are medication effects, for example corticosteroids could mask the antihypertensive benefits of exercise and can induce weakness due to steroid myopathy.…”

Section: Challenges Of Measuring Fatigue In Myasthenia Gravis (Mg)mentioning

confidence: 99%

“…The shortened version of the 2 min walk test has recently been described as a valid alternative to describe walking capability in patients with neuromuscular diseases and is chosen in patients who cannot complete the 6MWT due to fatigue or dyspnoea (24). An evaluation of the reliability of these tests was conducted on 31 patients with MG (MGFA class II or III) (25). On the first admission for testing, timed walk tests were performed at 3-h intervals on the same day, 1-2 h after pyridostigmine intake.…”

Section: Challenges Of Measuring Fatigue In Myasthenia Gravis (Mg)mentioning

confidence: 99%

Myasthenia Gravis and Physical Exercise: A Novel Paradigm

2020

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The benefits of physical exercise for healthy individuals are well-established, particularly in relation to reducing the risks of chronic lifestyle related diseases. Furthermore, physical exercise has been seen to provide beneficial effects in many chronic diseases such as multiple sclerosis, rheumatoid arthritis, and chronic obstructive pulmonary disease and is therefore recommended as part of the treatment regimen. Myasthenia Gravis (MG) is a chronic autoimmune disease that causes neuromuscular transmission failure resulting in abnormal fatigable skeletal muscle weakness. In spite of this fluctuating skeletal muscle weakness, it is reasonable to assume that MG patients, like healthy individuals, could benefit from some of the positive effects of physical exercise. Yet exercise-related research in the field of MG is sparse and does not provide any guidelines on how MG patients should perform physical training in order to obtain exercise's favorable effects without risking disease deterioration or more pronounced muscle fatigue. A handful of recent studies report that MG patients with mild disease activity can adhere safely to general exercise recommendations, including resistance training and aerobic training regimens, without subjective or objective disease deterioration. These findings indicate that MG patients can indeed improve their functional muscle status as a result of aerobic and high-resistance strength training. This knowledge is important in order to establish collective as well as personalized guidelines on physical exercise for MG patients. This review discusses the present knowledge on physical exercise in MG.

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“…It is important to point out that three healthy normative reference equations, commonly used in various neuromuscular studies, fail to meet our inclusion criteria. Currently, the published norms for the 6MWT most widely used are the Geiger norms for pediatric populations, and the Enright or Gibbons norms for adult populations.…”

Section: Discussionmentioning

confidence: 99%

Limitations of 6‐minute walk test reference values for spinal muscular atrophy

et al. 2020

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Introduction The 6‐minute walk test (6MWT) is a well‐established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease‐modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls. Methods The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values. Results Three pediatric and six adult studies were selected for comparison. The % predicted values using the pediatric and adult equations ranged from 47.7 ± 18.2% to 67.6 ± 26.2% and 43.0 ± 17.9% to 59.5 ± 26.2%, respectively, and were significantly different (P < 0.001). Discussion Results suggest significant variability between % predicted values derived from published reference equations in children and adults, despite adherence to 6MWT standardization.

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Functional exercise capacity evaluated by timed walk tests in myasthenia gravis

Abstract: The 6mWT and 2mWT have excellent test-retest reliability as well as moderate construct validity for the evaluation of functional exercise capacity patients with MG. Muscle Nerve, 2018.

Cited by 17 publications

References 31 publications

Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme

Changes in Cognitive Function and in the Levels of Glycosylated Haemoglobin (HbA1c) in Older Women with Type 2 Diabetes Mellitus Subjected to a Cardiorespiratory Exercise Programme

Myasthenia Gravis and Physical Exercise: A Novel Paradigm

Limitations of 6‐minute walk test reference values for spinal muscular atrophy

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