Functional finishing of medical fabrics using CeO2/allicin nanocomposite for wound dressings

Rajan, S. Thanka; Karthika, M.; Balaji, Umapathi; Muthappan, A.; Subramanian, B.

doi:10.1016/j.jallcom.2016.06.241

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…57 This is a new piece of evidence depicting the proinflammatory effects from diverse MNPs, for some MNPs (e.g., nZnO and nCeO 2 ) in fact revealed anti-inflammation effects in previous studies. 58,59 Similar proinflammatory responses induced by MNPs were also reported in previous studies. 60−62 Specifically, nZnO was reported to increase TNF-α secretion in animals and in RAW264.7 cells.…”

Section: ■ Discussion and Conclusionsupporting

confidence: 86%

“…Of note, no significant induction of NF-κB activity was demonstrated in MNP-treated cells, which should be ascribed to the relatively high basal activity of NF-κB in J774A.1 cells . This is a new piece of evidence depicting the proinflammatory effects from diverse MNPs, for some MNPs (e.g., nZnO and nCeO 2 ) in fact revealed anti-inflammation effects in previous studies. , Similar proinflammatory responses induced by MNPs were also reported in previous studies. − Specifically, nZnO was reported to increase TNF-α secretion in animals and in RAW264.7 cells. , Meanwhile, occupational exposure of MNP-containing toners was found to promote the inflammatory responses in copier operators, as made evident by provoked TNF-α and IL-1β levels . However, there are also inconsistent results in the literature.…”

Section: Discussionsupporting

confidence: 81%

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Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Zhang

Wang

Gao

et al. 2018

ACS Sustainable Chem. Eng.

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Thus far, tremendous efforts have been made to understand the biosafety of metal-based nanoparticles (MNPs). Nevertheless, most previous studies focused on specific adverse outcomes of MNPs at unrealistically high concentrations with little relevance to the National Institute for Occupational Safety and Health (NIOSH) exposure thresholds, and failed to comprehensively evaluate their toxicity profiles. To address these challenges, we here endeavored to multihierarchically profile the hazard effects of various popularly used MNPs in macrophages under low exposure doses. At these doses, no remarkable cell viability drop and cell death were induced. However, a cellular antioxidant defense system was seen to be initiated in cells by all MNPs even at these low concentrations, albeit to a differential extent and through different pathways, as reflected by differential induction of the antioxidant enzymes and Nrf2 signaling. Regarding inflammation, rare earth oxide nanomaterials (REOs) except nCeO2 greatly increased IL-1β secretion in a NLRP3 inflammasome-dependent manner. By contrast, six REOs, AgNP-5nm, nFe2O3, nFe3O4, and nZnO were found to elevate TNF-α concentration through post-transcriptional regulation. Moreover, all MNPs except nCeO2 drastically altered cellular membrane/cytoskeleton meshwork, but leading to different outcomes, with condensed cellular size and reduced numbers of protrusions by REOs and elongated protrusions by other MNPs. Consequently, REOs (e.g., nDy2O3 and nSm2O3) impaired phagocytosis of macrophages, and other MNPs (such as AgNP-25nm and nZnO) reversely enhanced macrophagic phagocytosis. Alterations of membrane and cytoskeleton meshwork induced by these MNPs also caused disordered membrane potential and calcium ion flux. Collectively, our data profiled the biological effects of different MNPs in macrophages under low exposure doses, and deciphered a complex network that links multiparallel pathways and processes to differential adverse outcomes.

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Section: ■ Discussion and Conclusionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 81%

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Zhang

Wang

Gao

et al. 2018

ACS Sustainable Chem. Eng.

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“…Cerium oxide (CeO 2 ), a rare earth metal oxide of the lanthanide series, has a face centered cubic fluorite-type crystal structure and exists in two oxidation states +3 and +4 [15,16]. The Ce 3+ /Ce 4+ redox switch and oxygen vacancies by surface defects make the CeO 2 nanoparticles have redox and biological activities, and can promote the growth and differentiation of osteoblasts, and improve the biological activity and antioxidant and anti-inflammatory ability of the biological materials [17][18][19]. Gojova et al [20] when studying the effect of metal particles on inflammatory response of vascular endothelial cells found that cerium dioxide has a certain anti-inflammatory ability.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Polyamide 6/CeO₂ Composite Nanofibers through Electrospinning for Biomedical Applications

Zhang

Chen

2019

International Journal of Polymer Science

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Polyamide 6 (PA6)/CeO2 composite nanofibers were prepared by electrospinning technique. The morphological, structural, and mechanical properties of the PA6/CeO2 nanofibers were investigated by using SEM, XRD, Fourier transform-infrared (FT-IR) spectroscopy, and an electronic universal tensile testing machine. SEM images revealed that the nanofibers were well oriented and had good incorporation with CeO2, the average diameter of composite fibers first decreases and then increases with the loading of CeO2. The crystallinity of fibers decreases after the addition of CeO2. The tensile strength of the fibers first increases and then decreases with the increasing concentration of CeO2. The proliferation properties of mouse macrophages and osteoblasts on the PA6/CeO2 nanofibers were analyzed by an in vitro cell compatibility test, the results show that PA6/CeO2 composite fibers is nontoxic to macrophages and osteoblasts and has good biocompatibility.

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“…Among the 28 included studies, 16 used CeO 2 nanoparticlecontaining materials, [2,4,6,11,13,14,17,[23][24][25][26][27][28][29][30][31] 4 used CeO 2 NPs, [15,16,32,33] and 8 used modified CeO 2 nanoparticles. [10,[34][35][36][37][38][39][40] The number of publications on CeO 2 over the recent decade and the proportion of included articles are indicated in Figure 3.…”

Section: Resultsmentioning

confidence: 99%

CeO₂ Nanoparticles to Promote Wound Healing: A Systematic Review

Xue,

Yang,

et al. 2023

Adv Healthcare Materials

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Cerium (Ce) is recognized as one of rare‐earth elements that has become a hot topic in the field of materials research due to its electronic layer structure, and unique antioxidant abilities of its oxide (CeO2). Cerium oxide nanoparticles (CeO2 NPs) have demonstrated their potential as an antioxidant and antibacterial agent. Current researches focused on whether they can be used to promote wound healing and in what manner. This article provides a systematic review of the various forms of CeO2 NPs that have been used in wound‐healing materials over the past decade, as well as the effectiveness demonstrated by in vivo and in vitro experiments, with a focus on the relationship between concentration and effectiveness. CeO2 NPs are expected to become effective ingredients in dressings that require antibacterial, antioxidant, and wound healing promoting properties. This article serves as a reference for further research and clinical applications of nano‐sized CeO2 in wound healing.This article is protected by copyright. All rights reserved

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Functional finishing of medical fabrics using CeO2/allicin nanocomposite for wound dressings

Cited by 13 publications

References 22 publications

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Preparation of Polyamide 6/CeO₂ Composite Nanofibers through Electrospinning for Biomedical Applications

CeO₂ Nanoparticles to Promote Wound Healing: A Systematic Review

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Functional finishing of medical fabrics using CeO2/allicin nanocomposite for wound dressings

Cited by 13 publications

References 22 publications

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Multihierarchically Profiling the Biological Effects of Various Metal-Based Nanoparticles in Macrophages under Low Exposure Doses

Preparation of Polyamide 6/CeO2 Composite Nanofibers through Electrospinning for Biomedical Applications

CeO2 Nanoparticles to Promote Wound Healing: A Systematic Review

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Product

Resources

About

Preparation of Polyamide 6/CeO₂ Composite Nanofibers through Electrospinning for Biomedical Applications

CeO₂ Nanoparticles to Promote Wound Healing: A Systematic Review