Functional fluorine-doped tin oxide coating for opto-electrochemical label-free biosensors

Burnat, Dariusz; Sezemsky, Petr; Lechowicz, Katarzyna; Koba, Marcin; Janczuk-Richter, Marta; Janik, Monika; Straňák, Vítězslav; Niedziółka‐Jönsson, Joanna; Bogdanowicz, Robert; Śmietana, Mateusz

doi:10.1016/j.snb.2022.132145

Cited by 20 publications

(26 citation statements)

References 73 publications

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“…Transparent conducting oxide thin films and particularly indium-tin-oxide (ITO) films find their applications in integrated touch sensors for flexible OLED displays, photovoltaic cells, LCDs, optical fiber sensor, gas sensing, analysis of ionized media and opto-electrochemical label free biosensors [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. ITO films are transparent, conducting and chemically stable and can be used for integrated-optic sensing applications.…”

Section: Introductionmentioning

confidence: 99%

Compact and efficient lossy mode resonant refractive index sensor for aqueous environment

Sharma

2024

J. Opt.

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A very short length high sensitivity, large figure of merit and very high resolution integrated-photonic refractometer for aqueous environment operating in visible region of wavelength is proposed. The sensor design depends on the periodic coupling of the guided dielectric optical waveguide mode field and the lossy mode field of the conducting Indium-tin-oxide thin film. Various layer thicknesses can be optimized to provide power transfer to the lossy layer and lossy mode resonance, resulting in a strong guided mode power absorption in the lossy layer occurs. The sensor has been designed to operate in both the TE and TM polarizations with different optimized layer thicknesses. The optimized thicknesses are different for TE and TM polarizations. The obtained numerical results show that a spectral sensitivity of 2200 nm/RIU/2645 nm/RIU for TE/TM mode could be achieved with a very high resolution. Also, the sensors can operate in power interrogation mode with maximum sensitivity nearly 5 x 107 dB/RIU.

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Section: Introductionmentioning

confidence: 99%

Compact and efficient lossy mode resonant refractive index sensor for aqueous environment

Sharma

2024

J. Opt.

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“…Exploring additional domains improve the sensor functionality by obtaining enhanced information about investigated target material, providing cross-verification of the readout, and enabling operation at a wider distance from the sensor's surface, but also make possible to observe additional perturbations resulting from crossinteractions between the domains. These are especially well-visible in the case of, for example, sensors employing semiconducting materials, such as indium tin oxide (ITO) 3 or fluorine-doped tin oxide (FTO) 4 . In these materials the distribution of majority charge carriers (electrons for the ITO/FTO films, as for n-type semiconductors) may effectively change at the interface with the analyte.…”

Section: Introductionmentioning

confidence: 99%

Does the refractive index sensitivity matter the most? Charge of biological material and performance of label-free biosensors

Janik

Niedziałkowski

Lechowicz

et al. 2023

European Workshop on Optical Fibre Sensors (EWOFS 2023)

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The work discusses the possible impact of the electric charge of biological material on the properties of label-free biosensors, in particular those operating in dual domains, i.e., optical and electrochemical. Optical fiber lossy-mode resonance (LMR) sensors based on indium tin oxide (ITO) were investigated as label-free biosensors with a model biological receptor-target pair, i.e., biotin-avidin. Each of the used biological materials shows different properties, i.e., size, isoelectric point, and, therefore, also charge. The investigations were performed in two electrolytes with differently charged redox couples to better identify the possible influence of chargé of biological material on the optical readout. The obtained results clearly indicate that in designing label-free biosensing solutions, consideration of a broader range of biological materials properties than just refractive index, such as their charge, is required.

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“…During label-free sensing, biological material attaching to the sensor's surface changes lossy-mode generation conditions and limits charge transfer between the working electrode and electrolyte. Such a multiple-domain sensing concept permits for cross-verification of the results and enhances the sensitivity obtained in each domain 7 .…”

Section: Introductionmentioning

confidence: 99%

Opto-electrochemical sensing of C-reactive protein using optical fiber lossy-mode resonance sensor

Burnat

Szot-Karpińska²,

Sezemsky

et al. 2023

European Workshop on Optical Fibre Sensors (EWOFS 2023)

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This work describes an experimental study towards label-free sensing of C-reactive protein (CRP) – a protein recognized as a inflammation marker. A multimode optical fiber with a section of its core coated with indium tin oxide (ITO) thin film was used as a sensor. ITO film allows for guiding lossy modes and can simultaneously be used as a transparent electrode for electrochemical measurements. Therefore, optical and electrochemical detection based on a single sensor was possible. Such a dual-domain approach is practical, especially when the results in one of the domains are not accurate enough, which was the case in this work. A case of different functionalization methods of ITO surface was also pointed out. The proposed sensor allows for recognition as low as ng/mL.

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Functional fluorine-doped tin oxide coating for opto-electrochemical label-free biosensors

Cited by 20 publications

References 73 publications

Compact and efficient lossy mode resonant refractive index sensor for aqueous environment

Compact and efficient lossy mode resonant refractive index sensor for aqueous environment

Does the refractive index sensitivity matter the most? Charge of biological material and performance of label-free biosensors

Opto-electrochemical sensing of C-reactive protein using optical fiber lossy-mode resonance sensor

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