Functional Food for the Stimulation of the Immune System Against Malaria

Bamgbose, Timothy; Anvikar, Anupkumar R.; Alberdi, Pilar; Abdullahi, I.O.; Inabo, Helen Ileigo; Bellò, Marilena; Cabezas-Cruz, Alejandro; Fuente, José de la

doi:10.1007/s12602-021-09780-w

Cited by 14 publications

(16 citation statements)

References 105 publications

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“…These results suggest that Plasmodium infection may affect the abundance, but also the composition and/or diversity of commensal bacteria associated with the host. This has been shown experimentally for murine malaria parasites [ 12 , 13 , 14 ]. By disrupting the microbiota-immune system homeostasis, malaria alters the profiles of mouse gut microbiome [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 56%

“…This has been shown experimentally for murine malaria parasites [ 12 , 13 , 14 ]. By disrupting the microbiota-immune system homeostasis, malaria alters the profiles of mouse gut microbiome [ 12 , 13 , 14 ]. Two independent studies provided evidence that infection with rodent malaria parasites Plasmodium yoelii [ 15 ] and Plasmodium berghei [ 16 ] resulted in alterations in the gut microbiome profile.…”

Section: Introductionmentioning

confidence: 56%

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Avian Malaria Parasites Modulate Gut Microbiome Assembly in Canaries

et al. 2023

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Rodent and human malaria parasites cause dysbiosis in the host gut microbiome, but whether Plasmodium species affecting birds cause dysbiosis in their hosts is currently unknown. Here we used a model of avian malaria infection to test whether parasite infection modulates the bird microbiome. To this aim, bird fecal microbiomes were characterized at different time points after infection of canaries with the avian malaria parasite Plasmodium homocircumflexum. Avian malaria caused no significant changes in the alpha and beta diversity of the microbiome in infected birds. In contrast, we discovered changes in the composition and abundance of several taxa. Co-occurrence networks were used to characterize the assembly of the microbiome and trajectories of microbiome structural states progression were found to be different between infected and uninfected birds. Prediction of functional profiles in bacterial communities using PICRUSt2 showed infection by P. homocircumflexum to be associated with the presence of specific degradation and biosynthesis metabolic pathways, which were not found in healthy birds. Some of the metabolic pathways with decreased abundance in the infected group had significant increase in the later stage of infection. The results showed that avian malaria parasites affect bacterial community assembly in the host gut microbiome. Microbiome modulation by malaria parasites could have deleterious consequences for the host bird. Knowing the intricacies of bird-malaria-microbiota interactions may prove helpful in determining key microbial players and informing interventions to improve animal health.

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Section: Introductionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 56%

Avian Malaria Parasites Modulate Gut Microbiome Assembly in Canaries

et al. 2023

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“…To take advantage of this potential, numerous live biotherapeutic products (LBPs), termed probiotics, have been developed recently, which not only offer the possibility to counteract pathogens but also to bring other health benefits, including restoring the gut microflora, providing immune modulation, maintaining bone health, relieving lactose intolerance, and decreasing the levels of LDL cholesterol [38][39][40]. For instance, Lactobacillus can generate innate and adaptive immune responses, produces antimicrobial substances, interacts with both intestinal epithelial cells (IECs) and dendritic cells (DCs), prevents pathogen colonization and proliferation, and activates antigen-specific response [41]. These live therapeutic agents must remain viable from the moment they are administered orally until they reach their target of interest in the small intestine [38].…”

Section: Introductionmentioning

confidence: 99%

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

et al. 2021

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Nutraceutical formulations based on probiotic microorganisms have gained significant attention over the past decade due to their beneficial properties on human health. Yeasts offer some advantages over other probiotic organisms, such as immunomodulatory properties, anticancer effects and effective suppression of pathogens. However, one of the main challenges for their oral administration is ensuring that cell viability remains high enough for a sustained therapeutic effect while avoiding possible substrate inhibition issues as they transit through the gastrointestinal (GI) tract. Here, we propose addressing these issues using a probiotic yeast encapsulation strategy, Kluyveromyces lactis, based on gelatin hydrogels doubly cross-linked with graphene oxide (GO) and glutaraldehyde to form highly resistant nanocomposite encapsulates. GO was selected here as a reinforcement agent due to its unique properties, including superior solubility and dispersibility in water and other solvents, high biocompatibility, antimicrobial activity, and response to electrical fields in its reduced form. Finally, GO has been reported to enhance the mechanical properties of several materials, including natural and synthetic polymers and ceramics. The synthesized GO-gelatin nanocomposite hydrogels were characterized in morphological, swelling, mechanical, thermal, and rheological properties and their ability to maintain probiotic cell viability. The obtained nanocomposites exhibited larger pore sizes for successful cell entrapment and proliferation, tunable degradation rates, pH-dependent swelling ratio, and higher mechanical stability and integrity in simulated GI media and during bioreactor operation. These results encourage us to consider the application of the obtained nanocomposites to not only formulate high-performance nutraceuticals but to extend it to tissue engineering, bioadhesives, smart coatings, controlled release systems, and bioproduction of highly added value metabolites.

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“…Therefore, no disturbance was observed at the pre-challenge stage for treatments with these probiotic bacteria. In contrast, at the pre-challenge stage the comparison of α-Gal treatment and control groups resulted in few differential taxa (Figure 8A), a result that supports a role for α-Gal glycan in shaping the microbiota composition [25,65,66]. However, at the post-challenge stage differentially abundant taxa were observed only in the P. entomophila probiotic treatment when compared to the control group (Figure 8B).…”

Section: Microbiota Composition Varies In Response To Treatment With Probiotic Bacteria and α-Galmentioning

confidence: 76%

Probiotic Bacteria with High Alpha-Gal Content Protect Zebrafish against Mycobacteriosis

et al. 2021

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Mycobacteriosis affects wild fish and aquaculture worldwide, and alternatives to antibiotics are needed for an effective and environmentally sound control of infectious diseases. Probiotics have shown beneficial effects on fish growth, nutrient metabolism, immune responses, disease prevention and control, and gut microbiota with higher water quality. However, the identification and characterization of the molecules and mechanisms associated with probiotics is a challenge that requires investigation. To address this challenge, herein we used the zebrafish model for the study of the efficacy and mechanisms of probiotic interventions against tuberculosis. First, bacteria from fish gut microbiota were identified with high content of the surface glycotope Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) that has been shown to induce protective immune responses. The results showed that probiotics of selected bacteria with high α-Gal content, namely Aeromonas veronii and Pseudomonas entomophila, were biosafe and effective for the control of Mycobacterium marinum. Protective mechanisms regulating immunity and metabolism activated in response to α-Gal and probiotics with high α-Gal content included modification of gut microbiota composition, B-cell maturation, anti-α-Gal antibodies-mediated control of mycobacteria, induced innate immune responses, beneficial effects on nutrient metabolism and reduced oxidative stress. These results support the potential of probiotics with high α-Gal content for the control of fish mycobacteriosis and suggested the possibility of exploring the development of combined probiotic treatments alone and in combination with α-Gal for the control of infectious diseases.

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Functional Food for the Stimulation of the Immune System Against Malaria

Cited by 14 publications

References 105 publications

Avian Malaria Parasites Modulate Gut Microbiome Assembly in Canaries

Avian Malaria Parasites Modulate Gut Microbiome Assembly in Canaries

Gelatin-Graphene Oxide Nanocomposite Hydrogels for Kluyveromyces lactis Encapsulation: Potential Applications in Probiotics and Bioreactor Packings

Probiotic Bacteria with High Alpha-Gal Content Protect Zebrafish against Mycobacteriosis

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