Functional Food XingJiuTang Attenuates Alcohol‐Induced Liver Injury by Regulating SIRT1/Nrf‐2 Signaling Pathway

Abstract

Lipid accumulation, inflammatory responses and oxidative stress have been implicated in the pathology of alcohol-induced liver injury (ALI). In this work, we evaluated the effects of the functional food XingJiuTang (XJT) on ALI and explored the underlying mechanism. We used alcohol-stimulated human normal hepatocytes L02 for in vitro experiments, while for in vivo experiments, 55 % alcohol was intragastrically administrated to C57BL/6 mice at 16 mL/kg with pre-administration of bifendate and XJT. Liver histology and function, along with the inflammatory cytokines, oxidative mediators and SIRT1/Nrf-2 pathway were evaluated. The results showed that XJT treatment significantly alleviated ALI, ameliorated lipid peroxidation, improved the liver function impaired by alcohol and inhibited the hepatocytes apoptosis in vitro and in vivo. In addition, XJT treatment modulated the activation of the SIRT1/Nrf-2 signaling pathway and suppressed the overexpression of NOX4. Overall, the functional food XJT effectively protects against experimental ALI via activating the SIRT1/Nrf-2 pathway.

Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice

“…Alcohol-, drug-, and toxin-induced liver injury can develop into liver fibrosis, cirrhosis, and even cancer, which has been deemed one of the most health-threatening diseases in the world ( Hou et al, 2019 ; Zhu et al, 2019 ; Shirani et al, 2020 ). At present, more attention is being given to the development of anti-liver injury agents from functional foods, such as edible herbs, due to their high efficacy, multiple targets, and low side effects ( Hao et al, 2020 ). In this study, we revealed the potential functional targets of SCU, an active flavonoid derived from the traditional Chinese herb E. breviscapus, through RNA-seq and gut microbiome 16 S rRNA-seq.…”