2020
DOI: 10.3390/cells9112347
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Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Abstract: A new epoch is emerging with intense research on nutraceuticals, i.e., “food or food product that provides medical or health benefits including the prevention and treatment of diseases”, such as Alzheimer’s disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuroprotective effects; in particular, they are able to provide protection against mitochondrial damage, oxidative stress, toxicity of β-amyloid and Tau and cell death. They have been shown to influence … Show more

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Cited by 44 publications
(27 citation statements)
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References 389 publications
(618 reference statements)
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“…8 In this context, a balanced anti-inflammatory diet such as the Mediterranean or the Asian diet may be successful candidates. [277][278][279][280][281][282][283] In contrast to the western diet, these…”
Section: Prevention/treatment Of Infectionsmentioning
confidence: 99%
See 1 more Smart Citation
“…8 In this context, a balanced anti-inflammatory diet such as the Mediterranean or the Asian diet may be successful candidates. [277][278][279][280][281][282][283] In contrast to the western diet, these…”
Section: Prevention/treatment Of Infectionsmentioning
confidence: 99%
“…Many components such as polyphenols, short chain fatty acids, flavonoids, proteins, vitamins B, curcumin and oligoelements (including selenium, copper, cobalt, magnesium) assure a healthy homeodynamic milieu decreasing the pro-inflammatory, pro-oxidant and epigenetic modulatory effects of the internal and external challenges. 178,[280][281][282][283][284][285][286][287][288][289][290][291][292] These diets have not only the advantage to decrease the propensity for chronic inflammations, but also reinforce the adaptive immune response. 172,[293][294][295] Recently GV-971, a new drug meant to regulate gut flora imbalance and reshape immune homeostasis, was approved in 2019 in China.…”
mentioning
confidence: 99%
“…Regarding the two potentially dangerous substances blamed for the green light in Alzheimer's disease, recent data show that amyloid and tau protein pathology should be triggered by some factors and then interact with each other, exerting a synergistic deleterious effect on the neural network, which is believed to initiate the progression of Alzheimer's disease (Morris et al, 2018 ). It is certain that alterations of amyloid and tau protein are currently ruled out as the sole cause of dementia, as it does not explain why about half of the world's population over the age of 45 have amyloid plaques and neurofibrillary tangles without dementia (Katzman, 1988 ; Price et al, 1992 ; Rowe et al, 2007 ; Jagust et al, 2009 ; Knopman et al, 2013 ; Atlante et al, 2020 ). The presence of amyloid plaques, which do not cause any disturbance, has been found in older adults who identify themselves with excellent cognitive functions (Katzman, 1988 ; Price et al, 1992 ; Rowe et al, 2007 ; Jagust et al, 2009 ; Knopman et al, 2013 ; Atlante et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…It is certain that alterations of amyloid and tau protein are currently ruled out as the sole cause of dementia, as it does not explain why about half of the world's population over the age of 45 have amyloid plaques and neurofibrillary tangles without dementia (Katzman, 1988 ; Price et al, 1992 ; Rowe et al, 2007 ; Jagust et al, 2009 ; Knopman et al, 2013 ; Atlante et al, 2020 ). The presence of amyloid plaques, which do not cause any disturbance, has been found in older adults who identify themselves with excellent cognitive functions (Katzman, 1988 ; Price et al, 1992 ; Rowe et al, 2007 ; Jagust et al, 2009 ; Knopman et al, 2013 ; Atlante et al, 2020 ). In these subjects, the average neurofibrillary tangle concentration was observed to increase exponentially with age (Price and Morris, 1999 ).…”
Section: Discussionmentioning
confidence: 99%
“…That ANT is a target of ROS in apoptosis was further confirmed by the use of certain dietary flavonoids known to exert beneficial effects on the central nervous system and to affect neuronal apoptosis [ 160 , 161 ]. The flavonoids genistein and daidzein, which are present in soy, but not catechin or epicatechin, which are present in cocoa, all used in a dietary blood concentration range, were found to prevent apoptosis in a manner consistent with their antioxidant activity [ 148 ], as depicted in Figure 3 .…”
Section: Ant: In Health and In Diseasementioning
confidence: 99%