Functional Formation of Domain V of the Poliovirus Noncoding Region: Significance of Unpaired Bases

Rowe, Alison; Burlison, J.; Macadam, Andrew; Pd, Minor

doi:10.1006/viro.2001.1111

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…This change, however, will result in higher genetic stability because it takes two mutations to convert an A:U pair to a more stable G:C pair, and the intermediates in this process (either G:U or A:C pairs) have a lower structural stability and hence lower fitness. A number of constructs created based on this principle were shown to have superior genetic stability and are now being considered as candidates for a more genetically stable vaccine virus (Macadam et al 2001(Macadam et al , 2006Rowe et al 2001).…”

Section: New Generation Of Polio Vaccinesmentioning

confidence: 98%

Current Status and Future of Polio Vaccines and Vaccination

Chumakov

2014

Novel Technologies for Vaccine Development

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The history of polio vaccines and their use illustrates the concept of evolution of vaccines driven by changing epidemiological and socioeconomic conditions. The development of two vaccines against poliomyelitis-inactivated Salk vaccine (IPV) and live oral Sabin vaccine (OPV)-is among the most consequential achievements of prophylactic medicine of the past century. Each with their own strengths and weaknesses, they were used over the past 50 years in different settings and different regimens and combinations. This resulted in virtual elimination of the disease in almost the entire world with the exception of a few countries. Continuation of the eradication campaign coordinated by WHO may soon result in complete cessation of wild poliovirus transmission, and poliovirus may join smallpox virus in the club of extinct pathogens. However, unlike smallpox vaccination that was stopped after the interruption of virus circulation, vaccination against poliomyelitis will have to continue into the foreseeable future, due to significant differences in the nature and epidemiology of the viruses. This chapter reviews the reasons for the need to maintain high population immunity against polioviruses, makes the case for developing a new generation of polio vaccines, and discusses their desirable properties as well as new vaccine technologies that could be used to create polio vaccines for the post-eradication environment.

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Section: New Generation Of Polio Vaccinesmentioning

confidence: 98%

Current Status and Future of Polio Vaccines and Vaccination

Chumakov

2014

Novel Technologies for Vaccine Development

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“…A number of genetic constructs created by this principle do have increased genetic stability. At present, they are supposed to be used to create virus-based vaccines with increased genetic stability [66][67][68].…”

Section: Problems and Prospects Of Creating New Poliovirus Vaccinesmentioning

confidence: 99%

The Development of Polio Vaccines: the Current Update (Review)

Ишмухаметов¹,

Siniugina²,

Chumakov³

2019

Sovrem Tehnol Med

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The dramatic history of the development and use of polio vaccines reflects the evolution of vaccine preparations under the influence of changing epidemiological conditions and socio-economic factors.The invention of two polio vaccines -the inactivated Salk vaccine and the live oral vaccine from Sabin strains, each with its own advantages and disadvantages -is on the list of the most significant medical achievements of the XX century. Over the past 50 years, these vaccines were used in various modalities, schemes, and combinations. As a result, poliomyelitis has been completely eradicated in almost all countries of the world. The sustained WHO-led efforts toward full eradication of the disease are expected to result in complete cessation of the virus circulation. In this case, the poliovirus, like the smallpox virus, will remain only in laboratories. However, it would be unreasonable to stop the vaccination even after the pathogen circulation has been stopped like it was in the case with the elimination of smallpox virus. Unlike the smallpox vaccination, vaccines against poliomyelitis will not lose their relevance in the near future because these two viruses significantly differ from each other in terms of biological and epidemiological characteristics.

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“…У ряда генно-инженерных конструкций, созданных на основе этого принципа, наблюдалась повышен-ная генетическая стабильность. В настоящее вре-мя их предполагается использовать для создания вакцин на основе вирусов с повышенной генетиче-ской стабильностью [94][95][96].…”

Section: новое поколение полиовакцинunclassified