2002
DOI: 10.1016/s0079-6123(02)38087-7
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Functional genomics and psychiatric illness

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Cited by 8 publications
(5 citation statements)
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References 72 publications
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“…Furthermore, we show that the differential regulation of histone methylation levels across various genomic loci remain detectable in human brain samples across a wide range of postmortem intervals and tissue pH. It is important to note that until now, analysis of mRNA levels was the only method available to measure gene expression activity in postmortem human and primate brain (Hasenkamp and Hemby, 2002;Pongrac et al, 2002). We predict that chromatin-based approaches, including histone methylation mapping, will become a valuable complement to mRNA profiling and could provide mechanistic insight into transcriptional regulation of specific genes in healthy and diseased human brain.…”
Section: Resultsmentioning
confidence: 69%
“…Furthermore, we show that the differential regulation of histone methylation levels across various genomic loci remain detectable in human brain samples across a wide range of postmortem intervals and tissue pH. It is important to note that until now, analysis of mRNA levels was the only method available to measure gene expression activity in postmortem human and primate brain (Hasenkamp and Hemby, 2002;Pongrac et al, 2002). We predict that chromatin-based approaches, including histone methylation mapping, will become a valuable complement to mRNA profiling and could provide mechanistic insight into transcriptional regulation of specific genes in healthy and diseased human brain.…”
Section: Resultsmentioning
confidence: 69%
“…Previously, we have employed similar approaches to identify molecular profiles of other diseases in human brain tissue including Alzheimer's disease, schizophrenia, drug abuse, as well as normal aging (Ginsberg et al . 2000; Hasenkamp and Hemby 2002; Hemby et al . 2002, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…Regional assessments of gene expression create an informative mosaic of expression level changes; however, determining the cellular origins of the gene expression has been complicated by cellular heterogeneity of subcortical brain regions and the ability to assess multiple genes in discrete neuronal populations. Single cell gene expression methodology combined with array technology can overcome some of these limitations by assessing multiple transcripts in specific target neuronal populations, providing a level of assessment heretofore unattainable (Ginsberg et al, 2000;Hasenkamp and Hemby 2002;Hemby et al, 2002Hemby et al, , 2003Fasulo and Hemby, 2003;Kamme et al, 2003). Future studies directed toward protein confirmation and functional relevance of the observed mRNA change are warranted.…”
Section: Discussionmentioning
confidence: 99%