Functional Genomics, Genetics, and Bioinformatics

Deng, Youping; Wang, Hongwei; Hamamoto, Ryuji; Schaffer, David; Duan, Shiwei

doi:10.1155/2015/184824

Cited by 1 publication

(1 citation statement)

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“…Genomics includes functional genomics, structural genomics, epigenomics, and macro-genomics. Different genomic analyses allow for describing the functions and interactions of genes and proteins, the three-dimensional structure of proteins, and epigenetically modified genetic material [ 11 ]. Genome-wide analysis plays an important role in discovering gene functions and better understanding the biological functions, pathogenic mechanisms, toxin degradation mechanisms, and beneficial mechanisms of bacteria.…”

Section: Introductionmentioning

confidence: 99%

A Bacillus subtilis Strain ZJ20 with AFB1 Detoxification Ability: A Comprehensive Analysis

Huang,

Guo,

Jia

et al. 2023

Biology

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As a class I carcinogen, aflatoxin can cause serious damage to various tissues and organs through oxidative stress injuries. The liver, as the target organ of AFB1, is the most seriously damaged. Biological methods are commonly used to degrade AFB1. In our study, the aflatoxin B1-degrading strain ZJ20 was screened from AFB1-contaminated feed and soil, and the degradation of AFB1 by ZJ20 was investigated. The whole genome of strain ZJ20 was analyzed, revealing the genomic complexity of strain ZJ20. The 16S rRNA analysis of strain ZJ20 showed 100% identity to Bacillus subtilis IAM 12118. Through whole gene functional annotation, it was determined that ZJ20 has high antioxidant activity and enzymatic activity; more than 100 CAZymes and 11 gene clusters are involved in the production of secondary metabolites with antimicrobial properties. In addition, B. subtilis ZJ20 was predicted to contain a cluster of genes encoding AFB1-degrading enzymes, including chitinase, laccase, lactonase, and manganese oxidase. The comprehensive analysis of B. subtilis provides a theoretical basis for the subsequent development of the biological functions of ZJ20 and the combinatorial enzyme degradation of AFB1.

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Section: Introductionmentioning

confidence: 99%