Functional genomics in yeast

Abstract

Completion of the Saccharomyces cerevisiae genome sequencing project in 1996 led to an incredible explosion of research on basic cellular processes and has provided the opportunity to determine how genes and their products are regulated and function on a genome-wide scale. The technologies that were developed from this provided an incredible array of tools to study cellular processes in great detail and were a paradigm for developments from subsequent sequencing projects.

Old English Swa Similes: Structure Overview

“…However, there have been some sporadic instances of simile analysis as a part of Old English comparative clauses or dative case functioning studies (Baker (2012), Fisher (1992), Gergel (2008), McLaughlin (1983), Merritt (2013), Mitchell (1985)). The semantic features of simile as a stylistic figure in certain literary works attracted the attention of Margolis (1957), who draws a comparison between simile and related devices; as do Walker (2016), Beardsley (1981), Dawes (1998), Tyler (2006); while Amodio (2014) and Stodnick (2012) touch upon similes when analysing Old English translations and adaptations of Latin texts. These works, however, are too few in number as well as too haphazardly related to afford a robust and reliable basis for the discussion of the phenomenon of the Old English simile.…”

“…Old English is well-known to have had a relatively free word order, which influenced the way simile constituents were organized into a construction. The terms "open simile" and "closed simile" have gained general acceptance in the simile semantics domain (Margolis (1957); Beardsley (1981); Dawes (1998); Walker (2016)). I will adopt this terminology to distinguish between the structural types of Old English simile as a useful tool to mark the grammatical non-expression/expression of the ground of simile, which will help to organize all the structures of similes with the swa component into a consistent paradigm.…”