Presentation tools of academic content are increasing in popularity for educators in Higher Education Institutions (HEI) who want to share ideas and information in a more creative and interactive environment using more effective tools and demand to involve. Interactive Applications are becoming lot more common and is more integrated into our everyday activities, like using mobile apps. The features of the Fourth Industrial Revolution (4IR) began to emerge through Interactive Applications (IAs) such as the applications of Augmented Reality (AR), Virtual Reality (VR), Mixed Reality (MR). Information resources development is no longer restricted and residing within the realm of speculative fiction. By using AR, VR and MR, academic libraries could already deliver a massive revolution in information retrieval. However, the biggest challenge that need to be tackled perhaps remains in how we could tune between these resources and the users so that the greatest possible benefit could be achieved in the light of accelerated technological development. This chapter uncovers the challenges and opportunities in using Interactive Applications (IAs) technologies and should be an eye opener for academic libraries that Interactive Applications technology are important to transform the use of traditional resources to interactive resources.