Functional hepatic reserve after arterial lipiodol-carboplatinum therapy in cirrhotic patients with hepatoma

Short-term effects of transcatheter arterial chemoembolisation on metabolic activity of the liver of cirrhotic patients with hepatocellular carcinoma.

“…Results-Intrinsic hepatic clearance of indocyanine green decreased significantly from (mean (SEM)) 355 (140) ml/min to 277 (98) m/min after the procedure (p= 0.0007). Galactose elimination capacity did not show significant changes, being 4.00 (0.90) mg/min/kg body weight at baseline, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] There is little information also on the effect of TACE in portal hypertension, as only a single report showing no relevant effect in portal hypertension has been published to date.6 However, an increase in portal hypertension could be hypothesised on the basis of recent findings6i7 and this can contribute to the deterioration in liver function in such subjects.…”

“…On the basis of pronounced but transient increase of parameters of hepatic cytolysis and considering the doubtful benefit on survival,3 a deleterious effect of TACE has been suspected; however a definite evaluation of the severity of such damage is still lacking. The small number of reports that used adequate quantitative techniques have conflicting results.45 …”