Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Zhang, Dao-Qi; Zhou, Tongrong; McMahon, Douglas G.

doi:10.1523/jneurosci.4478-06.2007

Cited by 114 publications

(160 citation statements)

References 41 publications

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“…Since the only remaining pathway that is known to be CNQX-sensitive is the OFF pathway, inhibition of OFF bipolar cells at light onset creates a crossover excitation which is presumably mediated by some amacrine cell circuit. Similar effects of L-AP4 and CNQX have been reported for ON-sustained DA cells (Zhang et al, 2007). Effects of both blockers were in part reversible.…”

Section: Glutamate-dependent Inputs To Type 2 Cellssupporting

confidence: 78%

Inputs Underlying the ON–OFF Light Responses of Type 2 Wide-Field Amacrine Cells in TH::GFP Mice

Knop

Feigenspan²,

Weiler³

et al. 2011

J. Neurosci.

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Section: Glutamate-dependent Inputs To Type 2 Cellssupporting

confidence: 78%

Inputs Underlying the ON–OFF Light Responses of Type 2 Wide-Field Amacrine Cells in TH::GFP Mice

Knop

Feigenspan²,

Weiler³

et al. 2011

J. Neurosci.

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“…The responses of dopaminergic neurons in mice to photopic light stimuli also varied. One set had transient responses at light onset, another set had sustained responses at light onset, and a third set was unresponsive to light, continuing to fire bursts of action potentials as they had in darkness (Zhang et al, 2007). If dopaminergic neurons in the rabbit retina respond similarly, the spontaneously active cells would account for the dopamine release we observed in darkness, and a subset of dopaminergic neurons would remain spontaneously active under all of our stimulus conditions.…”

Section: Functional Considerationsmentioning

confidence: 82%

Dopaminergic modulation of tracer coupling in a ganglion-amacrine cell network

et al. 2007

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Many retinal ganglion cells are coupled via gap junctions with neighboring amacrine cells and ganglion cells. We investigated the extent and dynamics of coupling in one such network, the OFF α ganglion cell of rabbit retina and its associated amacrine cells. We also observed the relative spread of Neurobiotin injected into a ganglion cell in the presence of modulators of gap junctional permeability. We found that gap junctions between amacrine cells were closed via stimulation of a D 1 dopamine receptor, while the gap junctions between ganglion cells were closed via stimulation of a D 2 dopamine receptor. The pairs of hemichannels making up the heterologous gap junctions between the ganglion and amacrine cells were modulated independently, so that elevations of cAMP in the ganglion cell open the ganglion cell hemichannels, while elevations of cAMP in the amacrine cell close its hemichannels. We also measured endogenous dopamine release from an eyecup preparation and found a basal release from the dark-adapted retina of approximately 2 pmol/min during the day. Maximal stimulation with light increased the rate of dopamine release from rabbit retina by 66%. The results suggest that coupling between members of the OFF α ganglion cell/ amacrine cell network is differentially modulated with changing levels of dopamine.

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“…Recordings from DA cells have indeed confirmed that light excites a proportion of these neurons and causes a transient or sustained increase in the frequency of their spontaneous activity [15].…”

Section: Structure and Connectivitymentioning

confidence: 85%

Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons

Hirasawa

Contini

Raviola

2015

Phil. Trans. R. Soc. B

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One contribution of 16 to a discussion meeting issue 'Release of chemical transmitters from cell bodies and dendrites of nerve cells'. In the mouse retina, dopaminergic amacrine (DA) cells synthesize both dopamine and GABA. Both transmitters are released extrasynaptically and act on neighbouring and distant retinal neurons by volume transmission. In simultaneous recordings of dopamine and GABA release from isolated perikarya of DA cells, a proportion of the events of dopamine and GABA exocytosis were simultaneous, suggesting co-release. In addition, DA cells establish GABAergic synapses onto AII amacrine cells, the neurons that transfer rod bipolar signals to cone bipolars. GABA A but not dopamine receptors are clustered in the postsynaptic membrane. Therefore, dopamine, irrespective of its site of release-synaptic or extrasynaptic-exclusively acts by volume transmission. Dopamine is released upon illumination and sets the gain of retinal neurons for vision in bright light. The GABA released at DA cells' synapses probably prevents signals from the saturated rods from entering the cone pathway when the dark-adapted retina is exposed to bright illumination. The GABA released extrasynaptically by DA and other amacrine cells may set a 'GABAergic tone' in the inner plexiform layer and thus counteract the effects of a spillover of glutamate released at the bipolar cell synapses of adjacent OFF and ON strata, thus preserving segregation of signals between ON and OFF pathways.

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Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Cited by 114 publications

References 41 publications

Inputs Underlying the ON–OFF Light Responses of Type 2 Wide-Field Amacrine Cells in TH::GFP Mice

Inputs Underlying the ON–OFF Light Responses of Type 2 Wide-Field Amacrine Cells in TH::GFP Mice

Dopaminergic modulation of tracer coupling in a ganglion-amacrine cell network

Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons

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