Functional imaging in obese children responding to long-term sports therapy

Kinder, Matthias; Lotze, Martín; Davids, Saarah F G; Domín, Martin; Thoms, K; Wendt, Julia; Hirschfeld, H.; Hamm, Alfons O.; Lauffer, Heinz

doi:10.1016/j.bbr.2014.06.037

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…Our results show that the number of responders for weight (27% vs 11%), BMI (71% vs 47%), and FMI (90% vs 47%) was higher in the group of children who performed exercise in addition to the family‐based lifestyle education program. One previous report in children and adolescents examining the interindividual variability after a multidisciplinary lifestyle intervention including exercise reported a lower prevalence of BMI responders than in our group of children participating in the program that included exercise (50% vs 71%). This difference may be explained by the different criteria used to define responders, or by differences in the design of the program.…”

Section: Discussioncontrasting

confidence: 73%

“…Occasionally, some studies have compared the prevalence of responders or non‐responders between different exercise intervention programs with the aim of knowing the most appropriate an effective design for the prevention/treatment of obesity or other obesity‐related comorbidities. Several studies in adults provided data of the interindividual variability in variables such as body composition or other health outcomes, while there is scarce evidence in the pediatric population . Our group has shown that the addition of supervised exercise to a family‐based lifestyle education program resulted in significantly greater reduction of percentage HF (≈20%) in children with overweight/obesity .…”

Section: Introductionmentioning

confidence: 83%

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Prevalence of responders for hepatic fat, adiposity and liver enzyme levels in response to a lifestyle intervention in children with overweight/obesity: EFIGRO randomized controlled trial

et al. 2019

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Background/Objective: Exercise and lifestyle interventions have been shown to reduce hepatic fat (HF) and adiposity in youth. However, the interindividual response in HF after a lifestyle intervention with or without exercise in children is unknown. The aim of the present study was to compare interindividual variability for HF, adiposity, gamma-glutamyl transferase (GGT), and the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) in children with overweight/obesity participating in a 22-week lifestyle intervention with (intensive intervention) or without exercise (control intervention).Methods: Data from 102 children (9-12 years, 55% girls) with overweight/obesity participating in the EFIGRO randomized controlled trial were analyzed. Percentage HF (magnetic resonance imaging), weight, body and fat mass index (BMI and FMI), GGT, AST/ALT, cardiorespiratory fitness (CRF, 20 meters shuttle run test) were assessed before and after the intervention by the same trained researchers. The control intervention consisted in 11 sessions of a family-based lifestyle and psycho-educational program. The intensive intervention included the control intervention plus supervised exercise (3 sessions/week).Results: The prevalence of responders for HF (54% vs. 34%), weight (27% vs. 11%), BMI (71% vs. 47%), FMI (90% vs. 60%), and GGT (69% vs. 39%) was higher in the intensive than in the control group (Ps < 0.05). Responders for weight (16 ± 3 vs. 6 ± 2 laps) and BMI (11 ± 2 vs. 3 ± 4 laps) improved more CRF levels than nonresponders (Ps < 0.05).Conclusions: The addition of exercise to a lifestyle intervention may increase the responder rates for HF, adiposity, and GGT in children with overweight/obesity.

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Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 83%

Prevalence of responders for hepatic fat, adiposity and liver enzyme levels in response to a lifestyle intervention in children with overweight/obesity: EFIGRO randomized controlled trial

et al. 2019

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“…Others suggest that reward areas, such as the insula, are affected by physical activity. However, changes in insular activity may be related to the processing of positive food images (whether high or low calorie) rather than the physical activity itself (Kinder et al 2014). Given the connections of the insula throughout the limbic system and medial pre-frontal cortex (Dupont et al 2003), emotion and motivational processing associated with food images and exercise is a likely reason for the increased insula activity following exercise.…”

Section: Discussionmentioning

confidence: 99%

Brain reactivity to visual food stimuli after moderate-intensity exercise in children

Masterson

Kirwan

Davidson

et al. 2017

Brain Imaging and Behavior

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Exercise may play a role in moderating eating behaviors. The purpose of this study was to examine the effect of an acute bout of exercise on neural responses to visual food stimuli in children ages 8-11 years. We hypothesized that acute exercise would result in reduced activity in reward areas of the brain. Using a randomized cross-over design, 26 healthy weight children completed two separate laboratory conditions (exercise; sedentary). During the exercise condition, each participant completed a 30-min bout of exercise at moderate-intensity (~ 67% HR maximum) on a motor-driven treadmill. During the sedentary session, participants sat continuously for 30 min. Neural responses to high- and low-calorie pictures of food were determined immediately following each condition using functional magnetic resonance imaging. There was a significant exercise condition*stimulus-type (high- vs. low-calorie pictures) interaction in the left hippocampus and right medial temporal lobe (p < 0.05). Main effects of exercise condition were observed in the left posterior central gyrus (reduced activation after exercise) (p < 0.05) and the right anterior insula (greater activation after exercise) (p < 0.05). The left hippocampus, right medial temporal lobe, left posterior central gyrus, and right anterior insula appear to be activated by visual food stimuli differently following an acute bout of exercise compared to a non-exercise sedentary session in 8-11 year-old children. Specifically, an acute bout of exercise results in greater activation to high-calorie and reduced activation to low-calorie pictures of food in both the left hippocampus and right medial temporal lobe. This study shows that response to external food cues can be altered by exercise and understanding this mechanism will inform the development of future interventions aimed at altering energy intake in children.

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Physical Activity Interventions for Neurocognitive and Academic Performance in Overweight and Obese Youth

Bustamante

Williams

Davis

2016

Pediatric Clinics of North America

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Functional imaging in obese children responding to long-term sports therapy

Cited by 4 publications

References 62 publications

Prevalence of responders for hepatic fat, adiposity and liver enzyme levels in response to a lifestyle intervention in children with overweight/obesity: EFIGRO randomized controlled trial

Prevalence of responders for hepatic fat, adiposity and liver enzyme levels in response to a lifestyle intervention in children with overweight/obesity: EFIGRO randomized controlled trial

Brain reactivity to visual food stimuli after moderate-intensity exercise in children

Physical Activity Interventions for Neurocognitive and Academic Performance in Overweight and Obese Youth

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