Functional imaging in orthopaedic infections—Update on immunoscintigraphy

Iyengar, Karthikeyan P; Ramesh, C.; Vinjamuri, Sobhan

doi:10.1016/j.cuor.2005.09.008

Cited by 2 publications

(1 citation statement)

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“…Moreover, antibodies, having a small molecular weight (antibody fragments), may accumulate in sites of sterile inflammation due to extravascular leaking with oedema, thus giving false positive results. Nevertheless, results of recently published studies in patients with PJI show the high diagnostic accuracy of radiolabelled antibodies (besilesomab and sulesomab), similarly to radiolabelled WBC (Iyengar et al, 2006;Blazeski et al, 2010;Richter et al, 2011;Sousa et al, 2011). Another study that compared an intact MoAb (besilesomab) with a fragmented MoAb AWJM Glaudemans et al…”

Section: Interpretation Criteriamentioning

confidence: 99%

Leukocyte and bacteria imaging in prosthetic joint infection

Glaudemans

Galli

Pacilio

et al. 2013

eCM

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There has been a significant increase in the number of joint prosthesis replacements worldwide. Although relatively uncommon, complications can occur with the most serious being an infection. Various radiological and nuclear imaging techniques are available to diagnose prosthetic joint infections (PJI). In this review article, we describe the pathophysiology of PJI, the principles of nuclear medicine imaging and the differences between Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET). The value of nuclear medicine techniques for clinical practice is also discussed.Then we provide an overview of the most often used radionuclide imaging techniques that may be helpful in diagnosing prosthetic joint infection: the 67 Ga-citrate, labelled white blood cells in vitro and in vivo (monoclonal antibodies directed against specific targets on the leukocytes), and 18 F-fluorodeoxyglucose ( 18 F-FDG). We describe their working methods, the pitfalls, and the interpretation criteria. Furthermore, we review recent advances in imaging bacteria, a molecular imaging method that holds promises for the detection of occult infections. We conclude proposing two diagnostic flow-charts, based on data in the literature, that could help the clinicians to choose the best nuclear imaging method when they have a patient with suspicion of or with proven PJI.

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Section: Interpretation Criteriamentioning

confidence: 99%