Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV

Varoquaux, A.; Rager, Olivier; Lövblad, Karl-Olof; Masterson, Karen; Dulguerov, Pavel; Ratib, Osman; Becker, Christoph; Becker, Minerva

doi:10.1007/s00259-013-2351-9

Cited by 86 publications

(85 citation statements)

References 47 publications

(82 reference statements)

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“…Interobserver reproducibility was assessed by the interobserver correlation coefficient. 30 An interobserver correlation coefficient value of Ͻ0.40 indicated poor reproducibility, 0.40 -0.59 indicated fair reproducibility, 0.60 -0.74 indicated good reproducibility, and Ͼ0.74 indicated excellent reproducibility. 31 An independent t test was used to compare significant differences between the AIs from ASL by observers 1 and 2 and between the AIs from SPECT and ASL.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Asymmetry Indices Measured by Arterial Spin-Labeling MR Imaging and SPECT in Patients with Crossed Cerebellar Diaschisis

Kang

Sohn

Kim

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Crossed cerebellar diaschisis, not only a secondary result of supratentorial infarction but also an indicator of clinical outcomes, has frequently been reported on PET and SPECT but has been rarely described with arterial spin-labeling MR imaging. The purpose of this study was to determine the ability of arterial spin-labeling MR imaging to evaluate crossed cerebellar diaschisis compared with that of SPECT. To our knowledge, this is the first study to validate arterial spin-labeling in crossed cerebellar diaschisis by using SPECT as a reference standard.

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Section: Discussionmentioning

confidence: 99%

Correlation of Asymmetry Indices Measured by Arterial Spin-Labeling MR Imaging and SPECT in Patients with Crossed Cerebellar Diaschisis

Kang

Sohn

Kim

et al. 2015

AJNR Am J Neuroradiol

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“…Nowadays, apparent diffusion coefficient (ADC) maps calculated from DW-MRI sequences are being increasingly used to provide quantitative data for head and neck lesion diagnosis. In malignant lesions, the DW-MRI signal increases and signal loss is observed on ADC maps (5,7,8). Many researchers benefited from this feature of DW-MRI and evaluated the effectiveness of DW-MRI for head and neck lesion identification, benign-malignant differentiation, and characterization of malignant lesions (9)(10)(11).…”

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confidence: 99%

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions

Şerifoğlu

Öz²,

Damar³

et al. 2015

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSEWe aimed to evaluate the role of apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging for head and neck lesion characterization in daily routine, in comparison with histopathological results. METHODSNinety consecutive patients who underwent magnetic resonance imaging (MRI) at a university hospital for diagnosis of neck lesions were included in this prospective study. Diffusion-weighted echo-planar MRI was performed on a 1.5 T unit with b factor of 0 and 1000 s/mm 2 and ADC maps were generated. ADC values were measured for benign and malignant whole lesions seen in daily practice. RESULTS Diagnosis of head and neck lesions is difficult due to the complicated anatomic structure and different histological components of the many tissues that the neck contains. Imaging of head and neck lesions is not only important for diagnosis of lesions, but also for differentiation of benign lesions from malignant lesions and staging of tumors. While conventional imaging methods mainly evaluate morphological properties, their value is limited in recognizing prognostic characteristics such as benign-malignant differentiation of lesions (1). Routine magnetic resonance imaging (MRI) is a time-consuming method, which is sensitive to differences between examiners and may require the use of contrast material. With development of rapid MRI sequences (such as echo-planar [EPI], fast advanced spin echo [FASE], split echo acquisition of fast spin echo [SPLICE]), the sensitivity to susceptibility artifacts limiting the use of MRI for the head and neck region and limitations linked to duration have been significantly reduced (2, 3).Diffusion-weighted magnetic resonance imaging (DW-MRI) is a short sequence produced from EPI, FASE, SPLICE sequences. DW-MRI is sensitive to the randomized (Brownian) motion of water molecules at a microscopic level, which provides functional information about tissues. DW-MRI was initially used to diagnose early stroke in the brain and to evaluate brain masses (4-6). Previous studies have shown that rapid growth of high-grade tumors like astrocytoma and lymphoma causes hypercellularity, which leads to limitation of the diffusion of water molecules. Nowadays, apparent diffusion coefficient (ADC) maps calculated from DW-MRI sequences are being increasingly used to provide quantitative data for head and neck lesion diagnosis. In malignant lesions, the DW-MRI signal increases and signal loss is observed on ADC maps (5,7,8). Many researchers benefited from this feature of DW-MRI and evaluated the effectiveness of DW-MRI for head and neck lesion identification, benign-malignant differentiation, and characterization of malignant lesions (9-11).In this prospective study, head and neck lesions that are seen in daily routine were evaluated using DW-MRI, and the role of ADC values in lesion characterization was investigated with the guidance of histopathological results. Methods PatientsFrom January 2012 to January 2014, 90 consecutive patients underwent MRI for diag...

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“…This study also reported a negative correlation, however, the study included only 7 patients with different tumor subsites (6). The existing studies in the literature either are not performed on an integrated PET/MR scanner or do not include patients with head and neck tumors (21,22,(34)(35)(36)(37)(38). The nonsignificant correlation found across patients suggests that information on glucose metabolism and cellularity from only 1 voxel, the voxel within the tumor either with the highest 18 F-FDG uptake (SUV max ) or with the lowest diffusion (ADC min ), may be too crude to adequately describe the tumor and depict a potential correlation.…”

Section: Discussionmentioning

confidence: 78%

Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma

et al. 2016

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The purpose of this study was to investigate and assess the correlation and reproducibility of multiparametric imaging in head and neck cancer patients. Methods: Twenty-one patients were included in this prospective scan-rescan study. All patients were scanned twice on an integrated PET and MRI scanner. Gross tumor volumes were defined on T2-weighted MR images, and volumes of interest were defined on diffusion-weighted MRI and 18 F-FDG PET (VOI DWI , VOI PET ). Overlap between volumes was assessed as a percentwise overlap. 18 F-FDG uptake and diffusion were measured using SUV and apparent diffusion coefficient, and correlation was tested across and within patients and as a voxel-by-voxel analysis. Results: Seventeen patients were available for correlation analysis, and 12 patients were available for assessment of tumor overlap. The median tumor overlap between VOI DWI and VOI PET was 82% (VOI DWI in VOI PET ) and 62% (VOI PET in VOI DWI ) on scan 1 and scan 2, respectively. Across patients, the correlation between SUV and apparent diffusion coefficient was weak and nonsignificant. However, in individual patients a weak but significant correlation was identified on a voxel-by-voxel basis. Conclusion: In multiparametric imaging with the integrated PET/MR scanner, the VOIs from DWI and 18 F-FDG PET were both within the target volume for radiotherapy and overlapped substantially although not completely. No correlation between 18 F-FDG uptake and DWI could be found across patients, but within individual patients a statistically significant, but weak, voxel-by-voxel correlation was found. The findings suggest that information on glucose uptake and diffusion coefficient carries complementary information of interest that may be relevant for radiotherapy treatment planning.

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Functional imaging of head and neck squamous cell carcinoma with diffusion-weighted MRI and FDG PET/CT: quantitative analysis of ADC and SUV

Cited by 86 publications

References 47 publications

Correlation of Asymmetry Indices Measured by Arterial Spin-Labeling MR Imaging and SPECT in Patients with Crossed Cerebellar Diaschisis

Correlation of Asymmetry Indices Measured by Arterial Spin-Labeling MR Imaging and SPECT in Patients with Crossed Cerebellar Diaschisis

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions

Feasibility of Multiparametric Imaging with PET/MR in Head and Neck Squamous Cell Carcinoma

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