Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells

Hüsing, Thea; Lange, Luisa; Rauschner, Mandy; Riemann, Anne; Thews, Oliver

doi:10.1007/978-3-030-48238-1_24

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…As compared to healthy tissues, tumor cells carry out glycolysis (Warburg effect) not only under hypoxic conditions but also in normoxic conditions, decreasing the extracellular pH (acidosis) due to increased glycolysis. As shown in a study by Hüsing et al (Hüsing et al, 2021), after incubation at pH 6.6, the cell adhesion and migration abilities in AT1 prostate cancer cells increased by 75% and 100%, respectively, which increased lung metastases in rats. These results showed that the extracellular pH had an important effect on the migration and adhesion of tumor cells.…”

Section: Discussionmentioning

confidence: 75%

Construction and validation of a glycolysis-related lncRNA signature for prognosis prediction in Stomach Adenocarcinoma

Liao

et al. 2022

Front. Genet.

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Background: Glycolysis is closely related to the occurrence and progression of gastric cancer (GC). Currently, there is no systematic study on using the glycolysis-related long non-coding RNA (lncRNA) as a model for predicting the survival time in patients with GC. Therefore, it was essential to develop a signature for predicting the survival based on glycolysis-related lncRNA in patients with GC.Materials and methods: LncRNA expression profiles, containing 375 stomach adenocarcinoma (STAD) samples, were obtained from The Cancer Genome Atlas (TCGA) database. The co-expression network of lncRNA and glycolysis-related genes was used to identify the glycolysis-related lncRNAs. The Kaplan-Meier survival analysis and univariate Cox regression analysis were used to detect the glycolysis-related lncRNA with prognostic significance. Then, Bayesian Lasso-logistic and multivariate Cox regression analyses were performed to screen the glycolysis-related lncRNA with independent prognostic significance and to develop the risk model. Patients were assigned into the low- and high-risk cohorts according to their risk scores. A nomogram model was constructed based on clinical information and risk scores. Gene Set Enrichment Analysis (GSEA) was performed to visualize the functional and pathway enrichment analyses of the glycolysis-related lncRNA. Finally, the robustness of the results obtained was verified in an internal validation data set.Results: Seven glycolysis-related lncRNAs (AL353804.1, AC010719.1, TNFRSF10A-AS1, AC005586.1, AL355574.1, AC009948.1, and AL161785.1) were obtained to construct a risk model for prognosis prediction in the STAD patients using Lasso regression and multivariate Cox regression analyses. The risk score was identified as an independent prognostic factor for the patients with STAD [HR = 1.315, 95% CI (1.056–1.130), p < 0.001] via multivariate Cox regression analysis. Receiver operating characteristic (ROC) curves were drawn and the area under curve (AUC) values of 1-, 3-, and 5-year overall survival (OS) were calculated to be 0.691, 0.717, and 0.723 respectively. Similar results were obtained in the validation data set. In addition, seven glycolysis-related lncRNAs were significantly enriched in the classical tumor processes and pathways including cell adhesion, positive regulation of vascular endothelial growth factor, leukocyte transendothelial migration, and JAK_STAT signaling pathway.Conclusion: The prognostic prediction model constructed using seven glycolysis-related lncRNA could be used to predict the prognosis in patients with STAD, which might help clinicians in the clinical treatment for STAD.

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Section: Discussionmentioning

confidence: 75%

Construction and validation of a glycolysis-related lncRNA signature for prognosis prediction in Stomach Adenocarcinoma

Liao

et al. 2022

Front. Genet.

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“…It has also been reported that the regulation of glutamine metabolism can upregulate ARPC1A in PC cells, resulting in changes in the PC cell cytoskeleton and the cells’ migration and invasion of the lungs[ 79 ]. Furthermore, the regulatory role of the positive feedback loop between tryptophan hydroxylase 1 and β-catenin/ZBP-89 signaling, as well as the modulation of microribonucleic acids in acidosis mediated by the Warburg effect, can enhance the metastatic ability of PC cells[ 80 , 81 ]. These findings indicate a close relationship between organism metabolism and the metastatic behavior of PC cells.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been found that silencing AKT1 downregulates epithelial-associated E-cadherin and upregulates mesenchymal-associated N-cadherin, promoting the occurrence of EMT closely related to PCLM[ 90 ]. Furthermore, some studies have indicated that decreased cell adhesion caused by C-terminal binding protein or metabolic acidosis-induced abnormal expression of microribonucleic acids enhances the metastatic ability of PC cells[ 81 , 91 ]. These findings suggest that abnormalities in cell-cell connections can enhance the likelihood of PC cell metastasis.…”

Section: Discussionmentioning

confidence: 99%

What should be the future direction of development in the field of prostate cancer with lung metastasis?

Huang,

Chen,

et al. 2023

World J Clin Oncol

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BACKGROUND Since the start of the 21 st century, prostate cancer with lung metastasis (PCLM) has accumulated significant scientific research output. However, a systematic knowledge framework for PCLM is still lacking. AIM To reconstruct the global knowledge system in the field of PCLM, sort out hot research directions, and provide reference for the clinical and mechanism research of PCLM. METHODS We retrieved 280 high-quality papers from the Web of Science Core Collection and conducted a bibliometric analysis of keywords, publication volume, and citation frequency. Additionally, we selected differentially expressed genes from global high-throughput datasets and performed enrichment analysis and protein-protein interaction analysis to further summarize and explore the mechanisms of PCLM. RESULTS PCLM has received extensive attention over the past 22 years, but there is an uneven spatial distribution in PCLM research. In the clinical aspect, the treatment of PCLM is mainly based on chemotherapy and immunotherapy, while diagnosis relies on methods such as prostate-specific membrane antigen positron emission tomography/computed tomography. In the basic research aspect, the focus is on cell adhesion molecules and signal transducer and activator of transcription 3, among others. Traditional treatments, such as chemotherapy, remain the mainstay of PCLM treatment, while novel approaches such as immunotherapy have limited effectiveness in PCLM. This study reveals for the first time that pathways related to coronavirus disease 2019, cytokine-cytokine receptor interaction, and ribosome are closely associated with PCLM. CONCLUSION Future research should focus on exploring and enhancing mechanisms such as cytokine-cytokine receptor interaction and ribosome and improve existing mechanisms like cadherin binding and cell adhesion molecules.

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Functional Impact of Acidosis-Regulated MicroRNAs on the Migration and Adhesion of Tumor Cells

Cited by 2 publications

References 9 publications

Construction and validation of a glycolysis-related lncRNA signature for prognosis prediction in Stomach Adenocarcinoma

Construction and validation of a glycolysis-related lncRNA signature for prognosis prediction in Stomach Adenocarcinoma

What should be the future direction of development in the field of prostate cancer with lung metastasis?

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