Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up

Elliott, Chris; Frith, James; Day, Christopher P.; Jones, David; Newton, Julia L.

doi:10.1007/s10620-013-2657-2

Cited by 51 publications

(64 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Antioxidants, modulators of nitric oxide, diuretics, and anti-apoptotic agents are current strategies for ameliorating or preventing LPS nephrotoxicity [26]. Nowadays, attention has focused on discovering natural, original compounds for protecting against renal injury, as well as accelerating tubular cell regeneration.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice

Xin

et al. 2016

Med Sci Monit

View full text Add to dashboard Cite

BackgroundSepsis can cause serious acute kidney injury in bacterium-infected patients, especially in intensive care patients. Luteolin, a bioactive flavonoid, has renal protection and anti-inflammatory effects. This study aimed to investigate the effect and underlying mechanism of luteolin in attenuating lipopolysaccharide (LPS)-induced renal injury.Material/MethodsICR mice were treated with LPS (25 mg/kg) with or without luteolin pre-treatment (40 mg/kg for three days). The renal function, histological changes, degree of oxidative stress, and tubular apoptosis in these mice were examined. The effects of luteolin on LPS-induced expression of renal tumor necrosis factor-α (TNF-α), NF-κB, MCP-1, ICAM-1, and cleaved caspase-3 were evaluated.ResultsLPS resulted in rapid renal damage of mice, increased level of blood urea nitrogen (BUN), and serum creatinine (Scr), tubular necrosis, and increased oxidative stress, whereas luteolin pre-treatment could attenuate this renal damage and improve the renal functions significantly. Treatment with LPS increased TNF-α, NF-κB, IL-1β, cleaved caspase-3, MCP-1, and ICAM-1 expression, while these disturbed expressions were reversed by luteolin pre-treatment.ConclusionsThese results indicate that luteolin ameliorates LPS-mediated nephrotoxicity via improving renal oxidant status, decreasing NF-κB activation and inflammatory and apoptosis factors, and then disturbing the expression of apoptosis-related proteins.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice

Xin

et al. 2016

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…More broadly, the association between ALP levels and better neurocognitive function may simply be a surrogate of the effects of improved liver function. Indeed, past work demonstrates cognitive impairments are prevalent and persisting in patients with non-alcoholic fatty liver disease (Elliot et al, 2013). Future studies with extended follow-ups (e.g., 5 years) should examine whether continued improvements in liver function after bariatric surgery translates to reduced risk of adverse brain changes and dementia in severely obese persons.…”

Section: Discussionmentioning

confidence: 99%

The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

Alosco

Spitznagel

Strain

et al. 2014

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Background The mechanisms for improved cognitive function post-bariatric surgery are not well understood. Markers of kidney and liver function (i.e., cystatin C and alkaline phosphatase (ALP)) are elevated in obese individuals and associated with poor neurocognitive outcomes in other samples. Bariatric surgery can improve cystatin C and ALP levels, but no study has examined whether such changes correspond to post-operative cognitive benefits. Methods 78 bariatric surgery patients completed a computerized cognitive test battery prior to and 12-months after surgery. All participants underwent an eight-hour fasting blood draw to quantify cystatin C and ALP concentrations. Results Cognitive function improved after surgery. Cystatin C levels decreased at the 12-month follow-up; however, no changes were found in ALP concentrations. At baseline, higher cystatin C levels predicted worse attention/executive function, but no such effects emerged for ALP. Regression analyses controlling for possible medical and demographic confounds and baseline factors revealed that decreased ALP levels following surgery predicted better attention/executive function and memory abilities. Post-surgery changes in cystatin C did not correspond to cognitive improvements. Conclusions Decreased ALP levels predicted better cognition following bariatric surgery, suggesting improved liver function as a possible mechanism of post-operative cognitive benefits. Future studies with neuroimaging and longer follow-up periods are needed to determine whether bariatric surgery can decrease risk for adverse brain changes and dementia in severely obese persons via improved metabolic function.

show abstract

“…129 Also, ratings of perceived exertion (a measure to monitor and prescribe exercise intensity) in patients with NAFLD were related to a metabolic factor (fasting glucose level) and level of physical activity in adulthood. 132 131 Patients with NAFLD also have disrupted levels of physical activity as daily activities of physical functioning.…”

Section: Nonalcoholic Fatty Liver Disease (Nafld)mentioning

confidence: 99%

Exercising the hepatobiliary‐gut axis. The impact of physical activity performance

Molina-Molina

Baccetto

Wang

et al. 2018

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up

Abstract: NAFLD and ALD patients experience significant functional impairment affecting activities of daily living that persists over time. This has implications for the management of liver disease and service provision.

Cited by 51 publications

References 19 publications

Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice

Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice

The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery

Exercising the hepatobiliary‐gut axis. The impact of physical activity performance

Contact Info

Product

Resources

About