Functional impairment of monocyte-derived dendritic cells in patients with severe chronic kidney disease

Abstract

These results show that the terminal differentiation of moDC in patients with severe CKD is impaired. This impairment is not restricted to one maturation stimulus and is independent of treatment with haemodialysis.

Allogeneic Mature Human Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in the Presence of IL-15

“…Immature moDCs are less capable of stimulating/activating T cells when compared with mature moDCs. As expected (44), DC maturation leads to significantly increased median fluorescence intensity (MFI) levels of HLA class II and costimulatory molecules CD40, CD80, and CD86 by at least 1-2 log (data not shown). Blocking the interaction of HLA class II molecules with the TCR (Fig.…”

Lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients

“…7,8 ESRD also results in dendritic cell (DC) depletion and dysfunction. [9][10][11] Given the critical role of DCs in regulation of innate and adaptive immunity, DC depletion can contribute to impaired defense against microbial infections and poor response to vaccination in this population. In addition to profoundly affecting the structure and function of innate immunity, CKD also impacts adaptive immunity mainly T and B lymphocyte.…”

Effect of virulent anaerobes on the outcome of peritoneal dialysis associated peritonitis

“…Functional abnormalities of monocytes, neutrophils, and dendritic cells are directly linked with infection risk in this patient population. 3,[8][9][10][11] Anaerobes are the most predominant components of the normal human skin and mucous membrane flora hence are the common cause of bacterial infections of endogenous origin. These infections contribute significantly to morbidity and mortality prompting us an early diagnosis and treatment.…”