Functional impairment of reading in patients with dry eye

Mathews, Priya; Ramulu, Pradeep Y.; Swenor, Bonnielin; Utine, Canan Aslı; Rubin, Gary S.; Akpek, Esen K.

doi:10.1136/bjophthalmol-2015-308237

Cited by 51 publications

(34 citation statements)

References 34 publications

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“…It is estimated to affect approximately 5% to over 50% of the population, depending on the diagnostic criteria, sex, and age. 1 , 2 DED is a symptomatic disease that combines ocular surface pain or discomfort and impaired visual function, 3 , 4 which greatly decreases patient quality of life. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Herbaut

Liang

Rabut

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeWe evaluated the relationship between ocular surface clinical tests and quality of vision in patients with dry eye disease (DED).MethodsIn this study, 136 eyes of 72 dry eye patients were evaluated retrospectively using the ocular surface disease index (OSDI), measurement of tear film break-up time (TBUT), the Oxford score, Van Bijsterveld score, and Schirmer I test. Quality of vision was assessed with the optical quality analysis system (OQAS) using the objective scatter index (OSI) recorded over 20 seconds without blinking. Correlations between dry eye symptoms and signs, and OSI measurements were evaluated.ResultsThe OSI and OSI standard deviation (OSI SD) were correlated with TBUT (r = −0.21, P = 0.013 and r = −0.18, P = 0.038, respectively), Oxford score (r = 0.31, P = 0.0002 and r = 0.18, P = 0.032, respectively), and the Van Bijsterveld score (r = 0.33, P = 0.0001 and r = 0.25, P = 0.003, respectively). The OSI also was correlated with the Schirmer test (r = −0.19, P = 0.025), OSDI (r = 0.17, P = 0.04), and the ocular symptoms subscale of the OSDI (r = 0.21, P = 0.01). OSI SD was correlated with the environmental triggers subscale of the OSDI (r = 0.21, P = 0.016).ConclusionsQuality of vision measured with the OQAS was correlated with dry eye symptoms and signs. The OQAS could be a useful tool to better evaluate visual function in patients with DED.Translational RelevanceThe OQAS provides a better understanding of patient complaints about alteration of vision quality. It might be useful to integrate this objective system in severity assessments and follow-up of DED, especially for treatment evaluations.

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Section: Introductionmentioning

confidence: 99%

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Herbaut

Liang

Rabut

et al. 2018

Trans. Vis. Sci. Tech.

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“…The impact of DED on vision also has functional implications to daily activities and quality of life. Studies have shown that reading rates are significantly reduced in DE patients vs control subjects, and deteriorating visual function correlated with DED severity [ 19 , 20 ]. This suggests that reduced visual function associated with DED can interfere with daily visual activities and quality of life.…”

Section: Discussionmentioning

confidence: 99%

Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye

McDonnell

Pflugfelder

Stern³

et al. 2017

BMC Ophthalmol

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BackgroundThe aim of this research is to initiate a 5-year natural history study of dry eye disease (DED) using objectively assessed and patient-reported outcomes, to explore the hypothesis that DED is a progressive condition that has substantive and measurable impacts not only on the ocular surface, but on quality of life and visual functioning. Our objective for this report is to examine the baseline data.MethodsA multicenter, prospective, controlled, observational study of Level 2 (mild-to-moderate) DED patients based on International Task Force Delphi Panel severity grading, and controls, documented baseline measures (including tear film biomarkers and quality of life). Tear cytokine concentrations were also measured in the tear film. Patients were using artificial tears as needed.ResultsTwo hundred seventeen DED patients and 67 gender- and age-matched controls were enrolled. A majority were females and Caucasian and groups did not differ significantly in terms of gender, race, or age. Differences between DED and matched controls, at baseline, included mean scores for Ocular Surface Disease Index (31.7 vs 4.1, P < 0.0001), Schirmer test (5.7 vs 15.3 mm, P < 0.0001), corneal staining (1.4 vs 0.2, P < 0.0001), conjunctival staining (1.4 vs 0.3, P < 0.0001), and tear break-up time (5.7 vs 8.5 s, P < 0.0001). Tear cytokines levels were determined and included interferon-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, tumor necrosis factor-α, epidermal growth factor, IL-13, IL-17, IL-1α, and inducible protein-10. The mean levels of IL-8 and IL-6 were slightly higher in the DED group at baseline. Blurred vision was reported as moderate/severe/very severe at baseline in 57.6% of DED patients vs.10.5% of normal controls (P < 0.0001). DED patients reported greater reductions in work and non-work productivity, as well as greater need for visits to ophthalmologists during the prior year.ConclusionsIn this report of the baseline findings of a 5-year natural history study of DED, a striking disease burden is observed with regard to blurred vision, productivity, and visits to eye care practitioners in mild to moderate DED patients compared to normal subjects of similar ages and genders.Trial registration ClinicalTrials.gov NCT00833235 on January 30, 2009.

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“…32,155,160 In particular, the vision-related quality of life is significantly influenced by dry eye owing to impairment of reading ability. [17][18][19] Although scarce, the existing data on the economics of dry eye suggest that the economic impact is substantial. Direct medical costs (e.g., office visits, prescription and over-thecounter medications, specialized eyewear, humidifiers, in-office procedures), direct nonmedical costs (e.g., patient transportation), indirect costs (e.g., lost work time and productivity, changes in type of work), and intangible costs (e.g., reduced quality of life, lost leisure time, impaired social, emotional, and physical functioning) determine the total cost of dry eye to the patient as well as to society.…”

Section: Socioeconomic Considerationsmentioning

confidence: 99%

“…15 Even though these symptoms often improve with treatment, the disease usually is not curable, which may be a source of patient and physician frustration. Importantly, dry eye is also a cause of reduced visual function [16][17][18][19] and may compromise results of corneal, cataract, and refractive surgery.…”

Section: Introductionmentioning

confidence: 99%

Dry Eye Syndrome Preferred Practice Pattern®

et al. 2019

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Functional impairment of reading in patients with dry eye

Abstract: Dry eye is associated with slower out-loud and silent reading speeds, providing direct evidence regarding the functional impact of dry eye. Reading speed represents a measurable clinical finding that correlates directly with dry eye severity.

Cited by 51 publications

References 34 publications

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye

Dry Eye Syndrome Preferred Practice Pattern®

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