Functional improvement in β cell models of type 2 diabetes using on-demand feedback control

Abstract

The bursting activity of pancreatic β cells is correlated with insulin secretion. Although normal pancreatic β cells show periodic bursting, the bursting activity becomes irregular in dysfunctional pancreatic β cells of type 2 diabetic patients. In this study, we modeled the dynamics of dysfunctional pancreatic β cells using differential equations. We investigated it in terms of energy efficiency of control. The control method is considered for on-demand electrical stimulation using the methodology of chaos control. Numerical simulation results show that the bursts are controlled in a periodic rhythm by the feedback mechanism. In addition, we found input timings that induce energy efficient control for rhythmic bursts. These results suggest that chaos control can improve insulin secretion, which might contribute to type 2 diabetes treatment.