Functional Interrogation of the AgRP Neural Circuits in Control of Appetite, Body Weight, and Behaviors

Han, Yong; Xia, Guobin; Wu, Qi

doi:10.1007/978-981-13-1286-1_1

Cited by 7 publications

(8 citation statements)

References 104 publications

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“…Interestingly, profiling of the spontaneous firing and membrane properties of ARC Drd1+ neurons revealed that, as a whole, they are less responsive than ARC AgRP/NPY+ neurons to fasting. Others have also measured the electrophysiological properties of ARC neurons given different experimental treatments, including fasting ( Liu et al., 2012 ), exercise ( Han et al., 2018 ), high fat diet (HFD) ( Baver et al., 2014 ; Wei et al., 2015 ; Jais et al., 2020 ), and gastric inputs ( Alhadeff et al., 2019 ; Goldstein et al., 2021 ; Jais et al., 2020 ). Ultimately, our results suggest the ARC Drd1+ neuronal population is heterogeneous.…”

Section: Discussionmentioning

confidence: 99%

Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons

Chadwick

Güler

2022

iScience

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Section: Discussionmentioning

confidence: 99%

Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons

Chadwick

Güler

2022

iScience

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“…The orexigenic effects of AgRP neurons are mediated by several AgRP neurocircuits that have been reviewed elsewhere (Deem et al, 2021; Han et al, 2018; Krashes, 2017; Sternson & Eiselt, 2017). Optogenetic stimulation of AgRP axonal projections to the BNST, LHA, MeA, PVH or the PVT drives food consumption (Figure 2) (Atasoy et al, 2012; Betley et al, 2013; Horio & Liberles, 2021; Padilla et al, 2016; Steculorum et al, 2016).…”

Section: Agrp Neuronal Regulation and Function During The Consummator...mentioning

confidence: 99%

“…AgRP neurons are dynamically regulated across each feeding phase by signals that are internally released or externally encountered sequentially and/or that possess different temporal regulatory effects on AgRP neuronal activity. Besides promoting hunger and motivating an animal to seek food, AgRP neurons act as ‘gate‐keepers’ of survival by protecting mice from starvation through the initiation of a large spectrum of hunger‐related behavioural and physiological responses (reviewed in Deem et al, 2021; Han et al, 2018). For instance, AgRP neuron activation allows the animal to overcome environmental stressors and prioritise behaviours but also shuts down highly energy‐demanding processes.…”

Section: Introductionmentioning

confidence: 99%

AgRP neuronal activity across feeding‐related behaviours

Gouveia

Beleza

Steculorum

2021

Eur J of Neuroscience

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AgRP neurons trigger one of the most potent orexigenic responses and are both necessary and sufficient for feeding. Recent technical advances for monitoring in vivo neuronal activity have revisited a previously well-established model of AgRP neurons' feeding regulatory effects. Our current understanding of AgRP neurons has increased in complexity and revealed a fine-tuned regulation of their activity dynamics across the whole sequence of feeding-related behaviours. This review focuses on recent studies that refined and re-evaluated our understanding of the regulatory principles and behavioural effects of AgRP circuits. We aim to cover major discoveries on the dynamic regulation of AgRP neuronal activity by exteroceptive and interoceptive food-related cues, their pleiotropic effects in feeding and whole-body homeostasis, and the associated AgRP circuits. The function and regulation of AgRP neuron will be sequentially discussed across the temporal series of behavioural and physiological changes occurring during the appetitive (food craving and foraging), the anticipatory (discovery of food-predicting cues), and the consummatory/postingestive phase of feeding (calorie ingestion).

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“…Metabolic status and fertility are affected by many neuronal populations, one of which is the arcuate population of agouti‐related peptide (AgRP) neurons. These neurons drive food intake in response to situations of caloric need, and are modulated by metabolically‐relevant hormones such as leptin and insulin 1 . They also provide a link to the hypothalamic–pituitary‐gonadal (HPG) axis, possibly through functional synaptic contact with GnRH neurons 2–4 and/or with arcuate and anteroventral kisspeptin neurons 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…These neurons drive food intake in response to situations of caloric need, and are modulated by metabolically-relevant hormones such as leptin and insulin. 1 They also provide a link to the hypothalamic-pituitary-gonadal (HPG) axis, possibly through functional synaptic contact with GnRH neurons [2][3][4] and/or with arcuate and anteroventral kisspeptin neurons. 5,6 It is likely that a complex network exists between AgRP neurons and other neurons of the GnRH neuronal network to coordinate reproductive activity.…”

mentioning

confidence: 99%

Agouti‐related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice

Decourt

Connolly

Ancel

et al. 2022

J Neuroendocrinology

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Agouti-related peptide (AgRP) neurons are thought to indirectly regulate the activity of hypothalamic gonadotrophin-releasing hormone neurons which control fertility. AgRP neurons also drive caloric intake and are modulated by metabolicallyrelevant hormones, providing a link to the hypothalamic-pituitary-gonadal axis. In mice expressing Cre-dependant designer receptors (DREADDs) in AgRP neurons, we activated or silenced these neurons in vivo using the synthetic ligand clozapine-N-oxide (CNO) to observe the effect of AgRP neuron activity on timing of puberty.To validate these animals, we chronically treated both stimulatory (hM3Dq) and inhibitory (hM4Di) DREADD Â AgRP-Cre mice with CNO, observing a pronounced increase and decrease of food intake, respectively, consistent with the known orexigenic effects of these neurons. RNAscope was performed to visually confirm the activation of AgRP neurons. Puberty onset was assessed in males and females.There was no effect on preputial separation in males or vaginal opening and first oestrus in females after CNO treatment from day 26 to 30 to chronically modulate AgRP neurons. Next, to determine whether the delay in puberty onset occurring in response to neonatal underfeeding could be overcome by inhibiting AgRP neuronal activity, mice were raised in large (neonatally underfed) or normal litter sizes. The delay in puberty from underfeeding was completely reversed in CNO-treated AgRP-hM4Di male mice. These data highlight the inhibitory role of AgRP neurons to delay puberty onset when undernutrition occurs during the neonatal period, at least in male mice.

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Functional Interrogation of the AgRP Neural Circuits in Control of Appetite, Body Weight, and Behaviors

Cited by 7 publications

References 104 publications

Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons

Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons

AgRP neuronal activity across feeding‐related behaviours

Agouti‐related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice

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