Functional Lipids in Autoimmune Inflammatory Diseases

Dei, Michele; Roda, Gabriella; Li, Feng; Secundo, Francesco

doi:10.3390/ijms21093074

Cited by 36 publications

(27 citation statements)

References 145 publications

(181 reference statements)

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“…Among those pathways, we detected three fatty acid related pathways, such as Fatty acid biosynthesis, Pantothenate and CoA biosynthesis and Fatty acid metabolism. It has been demonstrated that fatty acids play a role in various of RA processes, such as in ammation and pain, by interacting with immune cells like Th17 cells [29,30]. It has been demonstrated that fatty acid contributed synthesis of Th17 cells [31].…”

Section: Discussionmentioning

confidence: 99%

Association of the X-chromosomal hsa_circ_0140271 with Female Rheumatoid Arthritis

Chen¹,

Xu²,

Li³

et al. 2020

Preprint

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Background:Rheumatoid arthritis (RA) commonly affects women. Circular RNAs (circRNAs) have been reported to be related RA progress. However, it is still unknown the role of circRNA in female RA. Methods: In this study, we extracted total RNA of peripheral blood mononuclear cells (PBMC) from four RA patients and four healthy control donors, then performed RNA sequencing analysis. To validation, we recruited PBMC samples from 47 RA patients and 47 healthy control donors. The diagnosis ability of candidate circRNA in female RA was explored by Receiver Operating Characteristic (ROC) curve analysis. Levels of inflammation factors in serum, such as IL-1α, IL-1β, IL-6, IL-8,TNF-α and INF-γ, were detected in female RA patients and female healthy donors to analysis the correlation between those factors and candidate circRNA. KEGG pathway enrichment analyses were also performed to predict function of candidate circRNA.Resuluts: By analyzing circRNA expression profiles, we identified hsa_circ_0140271, generated from X chromosome gene-MED14, was specifically expressed in female RA patients. We verified hsa_circ_0140271 expression in PBMC samples from a cohort of 47 RA patients and 47 healthy control subjects via RT-qPCR and found hsa_circ_0140271 was also specifically highly expressed in female RA. In addition, ROC curve analysis indicated that the specificity of hsa_circ_0140271 in female RA patients was 1 comparing to female healthy subjects, osteoarthritis (OA) patients or Ankylosing spondylitis (AS) patients. Levels of IL-6, IL-8 and TNF-α was higher in serum from female RA patients than that from female healthy subjects. Furthermore, KEGG analysis indicated that hsa_circ_0140271 might regulate fatty acid metabolism in female RA patients.Conclusion:Our results suggested that hsa_circ_0140271 has a potential role in detect female RA and may contribute RA progress by fatty acid metabolism.

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Section: Discussionmentioning

confidence: 99%

Association of the X-chromosomal hsa_circ_0140271 with Female Rheumatoid Arthritis

Chen¹,

Xu²,

Li³

et al. 2020

Preprint

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“…Lipid alterations can be observed even before disease manifestations, which suggests that these molecules are closely linked to the most widespread metabolic changes caused by inflammation (associated with TNF-α) [ 138 , 139 ]. As a result, it is important to study in deep the lipid modulation by RA as it can provide potential markers for early diagnosis of this disease.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

et al. 2021

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Rheumatoid arthritis (RA) is a highly debilitating chronic inflammatory autoimmune disease most prevalent in women. The true etiology of this disease is complex, multifactorial, and is yet to be completely elucidated. However, oxidative stress and lipid peroxidation are associated with the development and pathogenesis of RA. In this case, oxidative damage biomarkers have been found to be significantly higher in RA patients, associated with the oxidation of biomolecules and the stimulation of inflammatory responses. Lipid peroxidation is one of the major consequences of oxidative stress, with the formation of deleterious lipid hydroperoxides and electrophilic reactive lipid species. Additionally, changes in the lipoprotein profile seem to be common in RA, contributing to cardiovascular diseases and a chronic inflammatory environment. Nevertheless, changes in the lipid profile at a molecular level in RA are still poorly understood. Therefore, the goal of this review was to gather all the information regarding lipid alterations in RA analyzed by mass spectrometry. Studies on the variation of lipid profile in RA using lipidomics showed that fatty acid and phospholipid metabolisms, especially in phosphatidylcholine and phosphatidylethanolamine, are affected in this disease. These promising results could lead to the discovery of new diagnostic lipid biomarkers for early diagnosis of RA and targets for personalized medicine.

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“…Several studies have proposed the use of eicosanoid precursors such as omega-3 polyunsaturated fatty acids (PUFAs) as candidates for the treatment of type 1 diabetes, SLE or RA. These molecules have anti-inflammatory properties ( 44 , 45 ). Also modulation of lipoxins, resolvins and protectins with aspirin is used in the treatment of SLE ( 46 ).…”

Section: Targeting Trained Immunity In Inflammatory and Autoimmune DImentioning

confidence: 99%

Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases

Municio

Criado

2021

Front. Immunol.

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The concept of trained immunity has recently emerged as a mechanism contributing to several immune mediated inflammatory conditions. Trained immunity is defined by the immunological memory developed in innate immune cells after a primary non-specific stimulus that, in turn, promotes a heightened inflammatory response upon a secondary challenge. The most characteristic changes associated to this process involve the rewiring of cell metabolism and epigenetic reprogramming. Under physiological conditions, the role of trained immune cells ensures a prompt response. This action is limited by effective resolution of inflammation and tissue repair in order to restore homeostasis. However, unrestrained activation of innate immune cells contributes to the development of chronic inflammation and tissue destruction through the secretion of inflammatory cytokines, proteases and growth factors. Therefore, interventions aimed at reversing the changes induced by trained immunity provide potential therapeutic approaches to treat inflammatory and autoimmune diseases like rheumatoid arthritis (RA). We review cellular approaches that target metabolism and the epigenetic reprogramming of dendritic cells, macrophages, natural killer cells, and other trained cells in the context of autoimmune inflammatory diseases.

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Functional Lipids in Autoimmune Inflammatory Diseases

Cited by 36 publications

References 145 publications

Association of the X-chromosomal hsa_circ_0140271 with Female Rheumatoid Arthritis

Association of the X-chromosomal hsa_circ_0140271 with Female Rheumatoid Arthritis

Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations

Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases

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