Functional localization of the system for visuospatial attention using positron emission tomography

Nobre, Anna C.; Sebestyen, G. N.; Gitelman, Darren R.; Mesulam, M. Marsel; Frackowiak, R. S. J.; Frith, C. D.

doi:10.1093/brain/120.3.515

Cited by 860 publications

(574 citation statements)

References 6 publications

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“…Located in the inferior parietal lobule, the angular gyrus serves as a multimodal association area, facilitating mental processes such as arithmetic (Arsalidou & Taylor, 2011), visuospatial attention (Nobre et al., 1997), memory (Kim, 2010; Spaniol et al., 2009; Vilberg & Rugg, 2008) sequence learning (Rosenthal, Roche‐Kelly, Husain, & Kennard, 2009), and semantic processing (Benson et al., 2001; Obleser, Wise, Dresner, & Scott, 2007; Price, Peelle, Bonner, Grossman, & Hamilton, 2016; Price, 2012). Further, the posterior aspect of the angular gyrus serves as part of the default mode network (DMN), which is most active during rest or fixation and becomes deactivated when performing cognitive tasks.…”

Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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IntroductionSpeech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology.MethodsResting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm3 (FWE<0.05).ResultsIn comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus.ConclusionsThe present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.

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Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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“…50 Via subcortico-cortical circuits, the STN is connected with the anterior cingulate cortex. 51 STN DBS seems to modulate anterior cingulate cortex activity in a task-specific manner 27,52 and might influence spatial orientation via the projections to anterior cingulate cortex of the right hemisphere.…”

Section: Discussionmentioning

confidence: 99%

Change in artistic expression related to subthalamic stimulation

Witt¹,

Krack²,

Deuschl³

2006

J Neurol

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While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L-dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere.

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“…Previous fMRI studies on dimension changes found significant activation of multiple posterior brain areas (e.g., Pollmann et al, 2000: fusiform gyrus, lateral occipital gyrus, superior/middle temporal gyrus, SPL and precuneus; Pollmann et al, 2006: IPS, fusiform gyrus, striate/peristriate cortex and posterior putamen/claustrum) that have been implicated in early attentional processes (Corbetta et al, 1993(Corbetta et al, , 1995(Corbetta et al, , 2000Corbetta & Shulman, 1999;Kelley et al, 2008;Macaluso et al, 2000;Nobre et al, 1997, Vandenberghe et al, 2000Yantis et al, 2002). Hence, it was concluded that dimension changes interfere with attention shifts to the target.…”

Section: Theoretical Implicationsmentioning

confidence: 99%

Distinct neural networks for target feature versus dimension changes in visual search, as revealed by EEG and fMRI

2014

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Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. A de nitive version was subsequently published in NeuroImage, 102, Part 2, 15 November 2014, 10.1016/j.neuroimage.2014.08.058. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractIn visual search, responses are slowed, from one trial to the next, both when the target dimension changes (e.g., from a color target to a size target) and when the target feature changes (e.g., from a red target to a green target) relative to being repeated across trials. The present study examined whether such feature and dimension switch costs can be attributed to the same underlying mechanism(s). Contrary to this contention, an EEG study showed that feature changes influenced visual selection of the target (i.e., delayed N2pc onset), whereas dimension changes influenced the later process of response selection (i.e., delayed s-LRP onset). An fMRI study provided convergent evidence for the two-system view: Compared with repetitions, feature changes led to increased activation in the occipital cortex, and superior and inferior parietal lobules, which have been implicated in spatial attention. By contrast, dimension changes led to activation of a frontoposterior network that is primarily linked with response selection (i.e., pre-motor cortex, supplementary motor area and frontal areas). Taken together, the results suggest that feature and dimension switch costs are based on different processes. Specifically, whereas target feature changes delay attention shifts to the target, target dimension changes interfere with later response selection operations.

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Functional localization of the system for visuospatial attention using positron emission tomography

Cited by 860 publications

References 6 publications

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Change in artistic expression related to subthalamic stimulation

Distinct neural networks for target feature versus dimension changes in visual search, as revealed by EEG and fMRI

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