Functional lumen imaging probe in gastrointestinal motility diseases

Chen, Hui Min; Li, Bai Wen; Li, Lian Yong; Xia, Liang; Chen, Xiang Bo; Shah, Rushikesh; Abdelfatah, Mohamed M.; Jain, Anrudh K.; Cassani, Lisa S.; Massaad, Julia; Keilin, Steve; Cai, Qiang

doi:10.1111/1751-2980.12818

Cited by 8 publications

(4 citation statements)

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“…The data by FLIP can be objectively interpreted in real-time, is less operator dependent, and allows for a more complete picture of esophageal physiology as compared to HRM. It can also predict the clinical outcomes of myotomy, whether done surgically or endoscopically [ 14 ]. The data on the LES makes FLIP particularly useful in the evaluation of achalasia and esophagogastric junction outflow obstruction (EGJOO), as these may be associated with DES [ 1 ].…”

Section: Reviewmentioning

confidence: 99%

Distal Esophageal Spasm: An Updated Review

Zaher¹,

Patel²,

Atia³

et al. 2023

Cureus

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Distal esophageal spasm is characterized by premature contractions of the distal esophageal smooth muscle leading to non-obstructive dysphagia and non-cardiac chest pain. Diagnosis requires the presence of symptoms along with evidence of at least 20% premature contractions in the setting of a normal lower esophageal sphincter relaxation on high-resolution manometry. New updates to the Chicago Classification have improved the diagnostic accuracy of this method. Functional lumen imaging probe is a growing diagnostic modality that gives a more complete picture of esophageal motility. Pharmacologic treatment remains inadequate. Endoscopic myotomy might be of benefit for non-achalasia esophageal motility disorders. More research is required to better understand the pathophysiology and develop safe and long-lasting management for this disease.

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Section: Reviewmentioning

confidence: 99%

Distal Esophageal Spasm: An Updated Review

Zaher¹,

Patel²,

Atia³

et al. 2023

Cureus

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“…The commercially available Endoflip system utilizes a 25 mm bag (Catheter 325N) that is used primarily for testing distensibility of the esophagus, lower esophageal sphincter, and anal sphincter. [11][12][13] We used a modified, custom designed Endoflip bag of 30 mm diameter with a larger bore catheter for injection of fluid into the bag.…”

Section: Concentric Endoflip Exercise Protocolmentioning

confidence: 99%

Do resistance exercises during biofeedback therapy enhance the anal sphincter and pelvic floor muscles in anal incontinence?

Tuttle

Zifan

Swartz

et al. 2021

Neurogastroenterology Motil

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Aim:To determine if a biofeedback therapy that includes concentric resistance exercise for the anal sphincter muscles can improve muscle strength/function and improve AI symptoms compared to the traditional/non-resistance biofeedback therapy.Background: Biofeedback therapy is the current gold standard treatment for patients with anal incontinence (AI). Lack of resistance exercise biofeedback programs is a limitation in current practice. Methods: Thirty-three women with AI (mean age 60 years) were randomly assigned to concentric (resistance) or isometric (non-resistance) biofeedback training. Concentric training utilized the Functional Luminal Imaging Probe to provide progressive resistance exercises based on the patient's ability to collapse the anal canal lumen. Isometric training utilized a non-collapsible 10 mm diameter probe. Both groups performed a biofeedback protocol once per week in the clinic for 12 weeks and at home daily.High definition anal manometry was used to assess anal sphincter strength; symptoms were measured using FISI and UDI-6. 3D transperineal ultrasound imaging was used to assess the anal sphincter muscle integrity.Results: Concentric and isometric groups improved FISI and UDI-6 scores to a similar degree. Both the concentric and isometric groups showed small improvement in the anal high-pressure zone; however, there was no difference between the two groups.Ultrasound image analysis revealed significant damage to the anal sphincter muscles in both patient groups. Conclusions: Concentric resistance biofeedback training did not improve the anal sphincter muscle function or AI symptoms beyond traditional biofeedback training. Anal sphincter muscle damage may be an important factor that limits the success of biofeedback training.

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“…There is a significant amount of literature describing the use of FLIP in adult patients with achalasia that supports its potential benefit in pediatrics [19,20]. At CHOP, FLIP is used to measure EGJ distensibility prior to an immediately after a balloon dilatation in patients with achalasia using the EF-325N catheter.…”

Section: Site Experiencesmentioning

confidence: 99%