Functional mapping and effective connectivity of the human operculum

Mălîia, Mihai-Dragoş; Donos, Cristian; Barborică, Andrei; Popa, Irina; Ciurea, Jean; Cinatti, Sandra; Mı̂ndruță, Ioana

doi:10.1016/j.cortex.2018.08.024

Cited by 67 publications

(44 citation statements)

References 89 publications

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“…Abnormal clinical memory function may be attributed to the abnormal graph theory index of the four overlapping nodes. The results were consistent with previous reports that the four overlapping nodes, including INS.L, ACG.L, ROL.L, and STG.R, were associated with memory and cognitive performance (Arnsten and Rubia, 2012;Maliia et al, 2018;Dimond et al, 2019). Notably, the four overlapping nodes, both with high participation coefficient and high node degree, were core nodes of network information exchange and integration and the absolute center of the network.…”

Section: Behavioral Significance Of Altered Nodal Metrics Across Thresupporting

confidence: 92%

“…Compared with the HC, the SCD showed decreased nodal efficiency in ROL.L, which might mean that in the evolution of the disease, the ROL.L was a priority to be affected. The operculum, adjacent to the insula, was responsible for sensory, motor, autonomic, and cognitive processing (Maliia et al, 2018). The ROL was a major region involved in the language processing system, which played an important role in a variety of neurologic and psychiatric conditions (Maliia et al, 2018;Shan et al, 2018;Zhan et al, 2019).…”

Section: Node Metrics Disruption Of Overlapping Nodes Across Three Grmentioning

confidence: 99%

“…The operculum, adjacent to the insula, was responsible for sensory, motor, autonomic, and cognitive processing (Maliia et al, 2018). The ROL was a major region involved in the language processing system, which played an important role in a variety of neurologic and psychiatric conditions (Maliia et al, 2018;Shan et al, 2018;Zhan et al, 2019). The proximity of the anatomical structures may be the reason why they have a similar tendency to change in the progression of the AD spectrum.…”

Section: Node Metrics Disruption Of Overlapping Nodes Across Three Grmentioning

confidence: 99%

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Disrupted Patterns of Rich-Club and Diverse-Club Organizations in Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment

Xue

Sun

et al. 2020

Front. Neurosci.

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Background: Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) were considered to be a continuum of Alzheimer's disease (AD) spectrum. The abnormal topological architecture and rich-club organization in the brain functional network can reveal the pathology of the AD spectrum. However, few studies have explored the disrupted patterns of diverse club organizations and the combination of rich-and diverse-club organizations in SCD and aMCI. Methods: We collected resting-state functional magnetic resonance imaging data of 19 SCDs, 29 aMCIs, and 28 healthy controls (HCs) from the Alzheimer's Disease Neuroimaging Initiative. Graph theory analysis was used to analyze the network metrics and rich-and diverse-club organizations simultaneously. Results: Compared with HC, the aMCI group showed altered small-world and network efficiency, whereas the SCD group remained relatively stable. The aMCI group showed reduced rich-club connectivity compared with the HC. In addition, the aMCI group showed significantly increased feeder connectivity and decreased local connectivity of the diverse club compared with the SCD group. The overlapping nodes of the rich club and diverse club showed a significant difference in nodal efficiency and shortest path length (L p) between groups. Notably, the L p values of overlapping nodes in the SCD and aMCI groups were significantly associated with episodic memory. Conclusion: The present study demonstrates that the network properties of SCD and aMCI have varying degrees of damage. The combination of the rich club and the diverse club can provide a novel insight into the pathological mechanism of the AD spectrum. The altered patterns in overlapping nodes might be potential biomarkers in the diagnosis of the AD spectrum.

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Section: Behavioral Significance Of Altered Nodal Metrics Across Thresupporting

confidence: 92%

Section: Node Metrics Disruption Of Overlapping Nodes Across Three Grmentioning

confidence: 99%

Section: Node Metrics Disruption Of Overlapping Nodes Across Three Grmentioning

confidence: 99%

See 1 more Smart Citation

Disrupted Patterns of Rich-Club and Diverse-Club Organizations in Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment

Xue

Sun

et al. 2020

Front. Neurosci.

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“…This hypothesis would contrast with the general scheme of motor pattern generation, which classically involves the cerebral hemisphere contralateral to the moving limb and the cerebellar hemisphere ipsilateral to it. In this regard, it should be also recalled that direct electrical stimulation of PO evoked motor effects only when applied to the left side, and that motor and sensory effects were mainly (90%) on the right side (Mălîia et al, 2018). In any case, it cannot be a priori excluded that the earlier phases of the motor act processing might involve both hemispheres.…”

Section: Discussionmentioning

confidence: 99%

“…Transcranial direct-current stimulation was applied by using a neuroConn ® DC-Stimulator Plus (model 0021) connected to two sponge electrodes, soaked with conductive gel. The active electrode (3.16 × 3.16 cm) was positioned on the scalp point closest to the PO of the non-preferred side (Figure 1C), as Mălîia et al (2018) reported motor effects only when applying direct electrical stimulation on this side. The electrode positioning was guided by a neuronavigation system (SofTaxic Optic 2.0, see Figure 1B).…”

Section: Methodsmentioning

confidence: 99%

Transcranial Direct Current Stimulation on Parietal Operculum Contralateral to the Moving Limb Does Not Affect the Programming of Intra-Limb Anticipatory Postural Adjustments

et al. 2019

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Recent data suggest that the parietal operculum acts as an integration center within a multimodal network, originating from different primary sensory and motor cortices and projecting to frontal, parietal and temporal cortical hubs, which in turn govern cognitive and motor functions. Thus, parietal operculum might also play a crucial role in the integrated control of voluntary movement and posture. As a first step to test this hypothesis, the Anticipatory Postural Adjustments (APAs) stabilizing the arm when the index-finger is briskly flexed were recorded, on the preferred side, in three groups of 10 healthy subjects, before, during and after CATHODAL or ANODAL transcranial Direct Current Stimulation (tDCS, 20 min at 2 mA) applied over the contralateral Parietal Operculum (coPO). Results were compared to those obtained in a SHAM group. In agreement with literature, in the SHAM group the activation of the prime mover Flexor Digitorum Superficialis was preceded by an inhibitory APA in Biceps Brachii and Anterior Deltoid, and almost simultaneous to an excitatory APA in Triceps Brachii. The same pattern was observed in both the CATHODAL and ANODAL groups, with no significant tDCS effects on APAs amplitude and timing. Index-finger kinematics were also unchanged. These negative results suggest that the coPO does not disturb the key network governing APAs in index-finger flexion. Since it has been well documented that such APAs share many features with those observed in trunk and limb muscles when performing several other movements, we suggest that coPO may not be crucial to the general APA control.

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Visceral and emotional responses to direct electrical stimulations of the cortex

Soulier

Mauguı̀ere

Catenoix

et al. 2022

Ann Clin Transl Neurol

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Objective Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas involved in the processing of these sensations remain unclear. Our objectives were to characterize the type and frequency of visceral and emotional responses evoked by electrical stimulations, to produce a mapping of brain structures involved in their processing, and to assess the link between visceral sensations and emotional feelings. Methods We reviewed 12,088 bipolar stimulations performed in 203 patients during the presurgical evaluation of drug refractory epilepsy. Responses to stimulation were divided into viscero‐sensitive, viscero‐vegetative, and emotional sensations. Univariate analysis and conditional logistic regression were used to assess the association between visceral and emotional sensations and localization of the stimulated contacts. Results In total, 543 stimulations evoked visceral and emotional sensations. Stimulations of operculo‐insulolimbic structures (amygdala, anterior and posterior insula, anterior and mid‐cingulate cortex, hippocampus, parahippocampus, temporal pole, frontal and parietal operculum) were significantly more associated with visceral and emotional sensations than all other cortical regions. Preferential implication of certain brain structures, depending on the type of visceral responses was evidenced: temporo‐mesial structures, insula, and frontoparietal operculum for viscero‐sensitive sensations; amygdala, insula, anterior and mid‐cingulate cortex, and temporal pole for viscero‐vegetative sensations; temporo‐mesial structures, anterior cingulate cortex, and frontal operculum for emotional sensations. Interpretation Our data can help to guide SEEG explorations when visceral or emotional symptoms are part of the ictal semiology. They also bring some insights into the mechanisms of visceroception and the functional significance of the co‐localization of visceral and emotional representations in the human brain.

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Functional mapping and effective connectivity of the human operculum

Cited by 67 publications

References 89 publications

Disrupted Patterns of Rich-Club and Diverse-Club Organizations in Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment

Disrupted Patterns of Rich-Club and Diverse-Club Organizations in Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment

Transcranial Direct Current Stimulation on Parietal Operculum Contralateral to the Moving Limb Does Not Affect the Programming of Intra-Limb Anticipatory Postural Adjustments

Visceral and emotional responses to direct electrical stimulations of the cortex

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